LBs的已知蛋白质涉及的蛋白质功能.docx
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LBs的已知蛋白质涉及的蛋白质功能
补充材料四（supplementarydata4）
第1部分（partone）
表1LBs的已知蛋白质统计表
Table1AlistofpreviouslyreportedproteincomponentsinLBsinimmunohistochemistrystudy
No.,proteinname,classification,andreferences
No.,proteinname,classification,andreferences
1.14-3-3proteinepsilon（14-3-3ε）#[1]
18.Alpha-internexin（INA）or66kDamicrofilamentsprotein（NF66）[14]
2.Cholineacetyltransferase（ChAT）[2]
19.Αlphatubulin（α-Tub）#[15]
3.ChromograninA（CgA）[3]
20.Betatubulin（β-Tub）#[15]
4.Dopaminetransporter（DAT）#[4,5]
21.TDPcaspasecleavageproduct（TDPccp）[16]
5.Synaptophysin（Syn）[3]
22.Gamma-tubulin（γ-Tub）[17]
6.Synaptotagmin
（Syt11）[6]
23.Gamma-aminobutyricacidtypeAreceptor-associatedprotein（GABARAP）[18]
7.Tyrosinehydroxylase（TH）#[7]
24.Gelsolin（GSN）orGelsolin-relatedamyloidprotein,Finnishtype[19]
8.Vesicularmonoaminetransporter2（VMAT2）#[8]
25.Histonedeacetylase6（HDAC6）[20
Neurotransmittermetabolism
26.Microtubulin-associatedprotein-1B（MAP-1B）#[21]
9.Cu/Znsuperoxidedismutase（C,Z-SOD）[9]
27.Microtubulin-associatedprotein-1C（MAP-1C）orDynein[22,23]
10.DJ-1[10]
28.Microtubule-associatedprotein-llight3（MAP-LC3orLC3）[18]
11.Mnsuperoxidedismutase（Mn-SOD）[9]
29.Microtubulin-associatedproteins-2（MAP-2）[24]
12.Nonseleniumglutathione（NSGP）[11]
30.Microtubulin-associatedproteins-5（MAP-5）[25]
Antioxidantdefensesystem
31.Microtubule-associatedproteintau（MAPTorTau）#[26]
13.Complementcomponent3d（C3d）[12]
32.Neurofilamentheaypolypeptide（NF-H）[27]
14.Complementcomponent4d（C4d）[12]
33.Neurofilamentlightpolypeptide（NF-L）[27]
15.Complementproteincomponent7（C7）[12]
34.Neurofilamentmediumpolypeptide（NF-M）[27]
16.Complementproteincomponent9（C9）[12]
35.Pericentrin（Pent）[17]
17.ImmunoglobulinG（IgG）[13]
36.Septin4（Sept4）[28]
37.Tropomyosine（Tm）[29]
60.Seveninabsentiahomologue1（SIAH1）[49]
Localimmunereactioninbrain
61.Sequestosome1（SQSTM1）orUbiquitin-bindingproteinp62（P62）#[50]
38.Tubulinpolymerizationpromotingprotein（TPPPorP25）[30]
62.Smallubiquitin-likemodifier1（SUMO1）[51]
Cytoskeletonnetwork
63.Ubiquitin（Ub）#[50]
39.CytochromeC（CytC）[31]
64.UbiquitinC-terminalhydrolaseL1（Uch-L1）#[52]
40.Glyceraldehyde-3-phosphatedehydrogenase（GAPDH）[32]
65.UbiquitinactivatingenzymeE1（Ube1）[17,53]
41.HightemperaturerequirementproteinA2（HtrA2）[33]
66.UbiquitinconjugatingenzymeE2isoform（UbcH7）[17]
42.PTEN-inducedkinase1（PINK1）[34]
67.E2-dependentubiquitin-proteinligaseE3parkin（Parkin）#[54]
Mitochondrialaerobicrespirationandmitochondrialpathwayofapoptosis
68.Tripartitemotif-containingprotein9（TRIM9）[55]
43.Betatransducinrepeatscontainingprotein（β-TrCP）[35]
69.Tumornecrosisfactor-receptorassociatedfactor6（TRAF6）[56]
44.Cullin-1（Cul-1）[36]
Ubiquitin-dependentand–independentproteasomeandlysosomedegradation
45.Dorfin[37]
70.14-3-3proteinzeta（14-3-3ζ）[57]
46.Liposomeassociateproteins（LAPs）[38,39]
71.Alphasynuclein（α-SYN）[58]
47.Lysosomal-associatedmembraneprotein2A（LAMP2A）[38,39]
72.Cterminusof70-kDaheatshockprotein-interactingprotein（CHIP）[59]
48.Glucocerebrosidase（GCD）[40]
73.DnaJ/Hsp40homologue,subfamilyB,member6（DnaJB6）[60]
49.NeighborofBrestcancer1geneprotein（NBR1）[41]
74.22-kDaheatshockprotein（HSP22）oralphaB-Crystallin（αB）[61]
50.Neuralprecursorcell-expressed,developmentallydown-regulatedprotein（NEDD8）[42]
75.27-kDaheatshockprotein（HSP27）[62]
51.NEDD8ultimatebuster（NUB1）[43]
76.32-kDaheatshockprotein（HSP32）orHemeoxygenase-1（HO1）[63]
52.Multicatalyticproteinase[44-46]
77.40-kDaheatshockprotein（HSP40）[64,65]
53.Proteasomesubunitbeta5（PSMB5）[47]
78.60-kDaheatshockprotein（HSP60）[64,65]
54.Proteasome26SsubunitATPase2（PSMC2）[47]
79.70-kDaheatshockprotein（HSP70）[64,65]
55.Proteasome26SsubunitATPase5（PSMC5）[47]
80.90-kDaheatshockprotein（HSP90）[64,65]
56.Proteasome26SsubunitATPase6（PSMC6）[47]
81.110-kDaheatshockprotein（HSP110）[64,65]
57.Proteasome26Ssubunitnon-ATPase11（PSMD11）[47]
82.70-kDaheatshockcognate（HSC70）[66]
58.Proteasome26Ssubunitnon-ATPase13（PSMD13）[47]
83.Synphilin-1（Sph1）#[58]
59.RegulatorofCullin-1（ROC1）[48]
84.T-complexpolypeptide1betasubunit（TCP-1β）[67]
85.TorsinA[65]
103.MAPKsp38isoform（P38）#[76]
86.Valosin-containingprotein（VCP）[68]
104.Mixedlineagekinase2（MLK2）[81]
Proteinfolding
105.MyxovirusresistencegeneAormyxovirusresistenceprotein1（MxA）[85]
87.Agrin#[69]
106.NuclearfactorκB（NFκB）[86]
88.Basicfibroblastgrowthfactor（bFGForFGF-2orFGF-β）[70]
107.Parkin-associatedendotheli
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