jp060652301994PRODUCTION OF LACTIDE丙交酯的制备.docx

jp060652301994PRODUCTION OF LACTIDE丙交酯的制备.docx

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jp060652301994PRODUCTIONOFLACTIDE丙交酯的制备

PATENTABSTRACTSOFJAPAN

（11）Publicationnumber:

06-065230

（43）Dateofpublicationofapplication:

08.03.1994

（51）Int.Cl.

C07D319/12

C07C51/00

C07C59/08

C07C69/68

//C07B61/00

（21）Applicationnumber:

04-220342

（71）Applicant:

SHOWADENKOKK

（22）Dateoffiling:

19.08.1992

（72）Inventor:

OKADAYOSHIHARU

SHIRASAWASONOKO

OGATAFUJIMARO

（54）PRODUCTIONOFLACTIDE

（57）Abstract:

PURPOSE:

Toobtainalactidebyusingsuchalowtoxic,highlyefficientcatalystastobeeasyinthesolutiontreatmentoftheresiduesleftafterreaction.

CONSTITUTION:

Theobjectivelactidecanbeobtainedbyheatinglow-molecularweightpolylacticacidat130-230°Cunderreducedpressuresinthepresenceofanalkalimetalcompoundfollowedbydistillingawaytheproductlactide.Tocarryoutthereactioninhigherefficiency,thelow-molecularweightpolylacticacidshouldbesuchoneastobeproducedbydehydratingcondensationoflacticacidinthepresenceofahigh-boilingalcoholunderreducedpressureatanelevatedtemperature.Thereby,theobjectivelactidecanbeobtainedinhigherefficiencycomparedwiththecaseusingconventionallyknowncatalysts.Thepresentcatalystisexcellentalsoinitseaseintheresiduetreatmentafterreaction.

CLAIMS

[Claim（s）]

[Claim1]Amanufacturingmethodoflactidewhichheatspolylacticacidoflowmolecularweightunderdecompressionunderexistenceofhydroxideofanalkalinemetal,asaltofanalkalinemetalandweakacid,oranalkoxideofanalkalinemetal,anddistillsoffgeneratedlactide.

[Claim2]Amanufacturingmethodofthelactideaccordingtoclaim1beingwhatobtainedwhenpolylacticacidoflowmolecularweightcarriesoutdehydrationcondensationofthelacticacidunderabasisofexistenceofhighboilingpointalcohol,anddecompression.

[Claim2]Amanufacturingmethodofthelactideaccordingtoclaim2,whereinhighboilingpointalcoholisfirst-classalcoholwiththeboilingpointhigherthan200**.

DETAILEDDESCRIPTION

[DetailedDescriptionoftheInvention]

[0001]

[IndustrialApplication]Thisinventionrelatestoamanufacturingmethodsimplelactideandefficient.

[0002]

[DescriptionofthePriorArt]Themethodoflactidecarryingoutdehydrationcondensationofthelacticacid,andobtainingthepolylacticacidoflowmolecularweight,andcarryingoutheatingdepolymerizationofthisandobtainingroughlactideisknownformanyyears.Generallyinthisdepolymerization,itisknownthatantimonousoxideispreferredasacatalyst.Therearesomereportsalsoaboutcatalystsotherthantheantimonousoxideusedformanufactureofthislactide..Forexample,usedastherawmaterialtheL-lacticacidwhichmakesatitaniumtetraalkoxideacatalyst.OpticallyAmanufacturingmethodofactivityLL-lactide（GermanypatentNo.1234703）,UnderthemetalfromperiodictablegroupIV,Vfellows,oragroupVIII,oritscompoundexistence,apolymerization,Then,amanufacturingmethodofthelactidebyperformingdepolymerization（GermanypatentNo.1083275）,usingtinoritscompoundforthemanufacturingmethod（GermanypatentNo.1543958）ofthelactidewhichusesleadstearate（II）forthecatalystofdepolymerization,andacatalyst--and--ontheway--onascaleofbeingindustrial,comingoutandaddingpolylacticacid,Itisamanufacturingmethod（JP,63-101378,A）etc.ofthelactidewhichobtainshighchemicalyieldandopticalpurity.Itisalreadyknownasacatalystoflactidemanufactureasmentionedaboveuntilnowthatsomemetalorthecompoundofthosecanbeused.Inparticular,inlactidemanufacture,tar-likeresidueoccursafterareactionandinareactor.Inordertoprocessthisresidue,residueisdissolvedinsodiumhydroxidesolutionorasuitableorganicsolvent,andbeingtakenoutfromareactionvesselismade,butthemetalusedasacatalystusuallyexistsinthesolutionofthisresiduetogetherwitholigomerofunreactedlacticacid,thedecompositionproductofthat,etc.Whenprocessingthisresiduedependingonthetoxicityofthemetalusedasacatalyst,existenceofthismetallicelementmakesprocessingofresiduewhathashighcost,and,asaresult,servesasabigprobleminmanufactureoflactide.

[0003]

[Problem（s）tobeSolvedbytheInvention]Usually,thereislittletoxicity,anditis[acertaindegree]preferred[compound]ifthemetalindustriallyusedasacatalystoritscompoundiseasyhandling.ThisinventionhaslittletoxicityandmakesitSUBJECTtoprovidethemanufacturingmethodofthelactidewhichusesthecheapcatalystwhichsolutionprocessingofresidueisnotonlyeasy,butcanmanufacturelactideefficiently.

[0004]

[MeansforSolvingtheProblem]Asaresultofexaminingamanufacturingmethodoflactide,theseresearchersbyusing