双语教学辅助资料Word格式文档下载.docx

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1-2Essentialpointsofconceptsofimmunology

CHATPTERTWOANTIGEN

2-1Basicconceptandtypesofantigen

2-2Themolecularbaseofantigen

2-3Theimmunologicalfeaturesofantigen

2-4Invasiveandinfectiousantigens

CHAPTERTHREEANTIBODIES

3-1Structuresandclassesofimmunoglobulins

3-2Thegeneofimmunoglobulins

3-3Synthesisandsecretionofimmunoglobulins

CHAPTERFOURCOMPLEMENTSYSTEM

4-1Compositionandphysiochemicalpropertiesofcomplementsystem

4-2Complementactivation

4-3Thecontrolofcomplementreactionandbiologicaleffectofcomplements

4-4Biosynthesisofcomplementandcomplementdeficiency

CHAPTERFIVECELLS,TISSUESANDORGANSOFIMMUNESYSTEM

5-1Thestructureandfunctionoforgansandlymphoidtissueandorgans

5-2Thecellsinimmunesystem

CHAPTERSIXMAJORHISTOCOMPATIBILITYCOMPLEX

6-1Structureandfunctionofmajorhistocompatibilityantigen

6-2Genestructureandgeneticsofmajorhistocompatibiltycomplex

6-3ThePrincipleandapplicationofdetectionforMHC

CHAPTERSEVENANTIGEN-ANTIBODYREACTIONANDITSAPPLICATION

7-1Antibodypreparations

7-2Theprincipleofantigen-antibodyreaction

7-3Commontechniquesinimmuno-analysis

CHAPTEREITHTCELLMEDIATEDIMMUNERESPONSE

8-1Basicconceptforimmuneresponse

8-2Thebasicprocessofimmuneresponse,

8-3Cellapoptosisandimmunity

CHAPTERNINEIMMUNEREGULATION

9-1Theregulationofantigenandantibodyintheimmuneresponse

9-2Theregulatoryeffectofimmunecellsinimmuneresponse

9-3InterleukinsandImmuneregulation

9-4Immunetolerance

CHAPTERTENHYPERSENSITIVITY

10-1TypeIHypersensitivity

10-2TypeIIHypersensitivity（CytotoxicHypersensitivity）

10-3TypeIIIHypersensitivity（Immunecomplexhypersensitivity）

10-4TypeIVHypersensitivity（DelayedTypeHypersensitivity）

CHAPTERELEVENABNORMALIMMUNERESPONSES

11-1Autoimmuneresponse

11-2TransplantationImmunology

11-3Anti-tumorImmunology

11-4Immunologicdeficiency

CHAPTERTWELVETHEEVOLUTIONOFIMMUNESYSTEM

12-1Theimmunityofinvertebrateanimals

12-2Theimmuneevolutionofvertebrateanimals

CHAPTERONEINTRODUCTION（绪言）

1-1-1Infectionandimmunityofdiseases

1-1-2FoundationanddevelopmentofthedisciplineofImmunology

1-1-3RecentdevelopmentofImmunology

1-2-1Innateimmunityandacquiredimmunity

1-2-2Immuneresponse

1-2-3Immunologyandpracticallyapplications

1-2-4BranchesofImmunologyandtheirdevelopment

Theterm“IMMUNITY”,originally,andmightstillbeconsideredbypeople,meanstheabilityofhosttoresistancetoinfectiousdisease.However,themodernconceptofimmunityisconferringthehostthespecificfunctiontorecognizeandneutralizeand/oreliminateforeignmaterialsorsubstances（biologicalornon-biological,andevensometimeselftissuecomponents）tomaintainthehomeostasisofhostinternalenvironment.

Immunityincludesinnateimmunityandacquiredimmunity,theformerisinherent,veryquick,andnon-specificrespondtoinvasivepathogens;

whereasthelatterisacquiredandadaptedafterbirthofhost,andinducedspecificrespondtoforeignmaterial（infectiousornoninfectious）.

TheImmunologyisastudytofocusingonhowofhosttorecognitionofselfandnon-self,andhowoftheresponsetoforeignmaterial（Antigen）and

1-1-1Infectionofandimmunitytodiseases

Fetalepidemicdisease,smallpox（variola）,deadratebysmallpox30-40%;

killedmillionsofpeoplesinthisglobebeforenineteenthcentury.

FromSongDynastyChinesedoctorinvestedatechniquecalledvariolation（人痘接种法）topreventchildrenfromsmallpox

1798,anyoungdoctorinEngland,Jenner,createdanewmethod,vaccination（牛痘接种法）,topreventthechildrenfromsmallpox,andfinally,byusingthisveryeffectivetechnique,thesmallpox,afatalepidemicdiseasehasbeeneliminatedintheworld,statedbytheWHOin1979.

orbilitysmallpox,measles

（,thypho,cholera（伤寒），anthrax

鼠疫鼠疫，疟疾malaria

（1）1.Foundationofimmunology

（1）LouisPasteur,wasafamousbiochemistinFrancein19thcentury,contributedhislotsofefforttoimmunizationtopreventanimalandhumanfromseveralseriousdiseases（cholera霍乱,anthrax炭疽,rabies（狂犬病）---vaccination---activeimmunization

（2）.Developmentofexperimentalimmunology

1-1-3RecentdevelopmentofImmunology

（1）.Humoralimmunology,

（2）.Cellularimmunology

1-2-2immuneresponse

Basicconceptordefinitionfortheterm“IMMUNITY”,originally,andusuallystillbeconsideredbycommonpeople,meanstheabilityofhosttoresistancetoinfectiousdisease.However,atpresent,themodernconceptofimmunity,isconferringthehostspecificfunctionstorecognizeandfinalneutralizeand/oreliminateforeignmaterialsorsubstances（biologicalornon-biological,andevensometimeself）tomaintainthehomeostasisofhostinternalenvironment.

Immunityincludeinnateimmunityandacquiredimmunity,theformerisinherent,veryquick,andnon-specificrespondtoinvasivepathogens;

（,thypho,cholera（伤寒）霍乱，anthrax炭疽

CHATPTERTWOANTIGEN（抗原）

2-1-1antigenandimmunogen

2-1-2classes/typesofantigen

2-2-1chemicalfeaturesofantigen

2-2-2antigendeterminants

2-3-1Theexogenicityofantigen

2-3-2Therelationofimmunogenecitytoindividualandimmunizationmanner

2-3-3Thespecificityofantigenandimmuno-predominanceofantigen

2-3-4Theimmunologicfeatureofhapten

2-4-1Bacteria

2-4-2Fungi

2-4-3virus

2-4-3Virus

CHAPTERTHREEANTIBODIES（抗体）

3-1StructuresandclassesofImmunoglobulins

3-1-1Thebasicstructureofantibodies

3-1-2Classesandtypesofimmunoglobulins

3-2-1Thegenestructuresofimmunoglobulins

3-2-2Rearrangementandexpressionofimmunoglobulingenes

3-2-3Thediversityofimmunoglobulingenes

3-3Synthesisandsecretionofimmunoglobulin

3-3-1Humoralimmuneresponseandtheproductionofantibodies

3-3-2Expression,assembleandsecretionofimmunoglobulin

CHAPTERFOURCOMPLEMENTSYSTEM（补体系统）

4-1-1Nomenclatureofcomplementcomponents

4-1-2Thephysiochemicalpropertiesofcomplementcomponents

4-2-1TheClassicalpathwayofcomplementactivation

4-2-2Thelectinpathwayofcomplementactivation

4-2-3Thealternativepathwayofcomplementactivation.

4-2-4Membranelysingcomplexformationinlatephaseofcomplementactivation

4-2-5Comparisonofthreepathwaysincomplementactivation

4-3-1Regulatingproteinofcomplementactivationinserum

4-3-2Regulateproteinonthesurfaceofcellmembrane

4-3-3Complementreceptors

4-3-4Thebiologicalfunct