实验5 利用Entrez SRS 工具检索权关核酸蛋白数据库.docx
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实验5利用EntrezSRS工具检索权关核酸蛋白数据库
实验五利用Entrez、SRS工具检索权关核酸蛋白数据库
1.LimitsActivated:
excludepatents,Sourcedatabase:
EMBL
（1）.HepatitisBviruscompletegenome,genotypeA2,isolateP2.2.11
GenBank:
HE576989.1
FASTAGraphics
Goto:
∙Features
∙Sequence
LOCUSHE5769893221bpDNAcircularVRL29-JUL-2011
DEFINITIONHepatitisBviruscompletegenome,genotypeA2,isolateP2.2.11.
ACCESSIONHE576989
VERSIONHE576989.1GI:
341823528
KEYWORDScompletegenome.
SOURCEHepatitisBvirus
ORGANISMHepatitisBvirus
Viruses;Retro-transcribingviruses;Hepadnaviridae;
Orthohepadnavirus.
REFERENCE1
AUTHORSMartel,N.,Cotte,L.,Trabaud,M.A.,Trepo,C.,Zoulim,F.,Gomes,S.
andKay,A.
TITLEGlucocorticoid-inducedreactivationofanoccultHBVinfectionin
anHIV+patient
JOURNALUnpublished
REFERENCE2（bases1to3221）
AUTHORSKay,A.C.
TITLEDirectSubmission
JOURNALSubmitted（22-JUL-2011）totheINSDC.KayA.C.,U1052,INSERM,151
coursAlbertThomas,Lyon,69003,FRANCE
FEATURESLocation/Qualifiers
source1..3221
/organism="HepatitisBvirus"
/mol_type="genomicDNA"
/serotype="ayw1"
/isolate="P2.2.11"
/db_xref="taxon:
10407"
/country="France"
/collection_date="09-Jun-2007"
/note="genotype:
A2"
geneorder（2307..3221,1..1623）
/gene="pol"
CDSjoin（2307..3221,1..1623）
/gene="pol"
/function="viralpolymerase"
/codon_start=1
/product="reversetranscriptase-DNApolymerase"
/protein_id="CCC82739.1"
/db_xref="GI:
341823532"
/translation="MPLSYQHFRKLLLLDDGTEAGPLEEELPRLADADLNRRVAEDLN
LGNLNVSIPWTHKVGNFTGLYSSTVPIFNPDWQTPSFPKIHLQEDIINRCQQFVGPLT
VNEKRRLKLIMPARFYPTHTKYLPLDKGIKPYYPDQVVNHYFQTRHYLHTLWKAGILY
KRETTRSASFCGSPYSWEQELQHGRLVIKTSQRHGDESFCSQPSGILSRSSVGPCIRS
QLKQSRLGLQPHQGPLASSQPGRSGSIRARAHPSTRRYFGVEPSGSGHIDHSVNNSSS
CLHQSAVRKAAHSHLSTSKRQSSSGHAVESHCLPPSSAGSQSQGSVFSCWWLQFRNSK
PCSEYCLSHLVNLREDWGPCDEHGEHHIRIPRTPARVTGGVFLVDKNPHNTTESRLVV
DFSQFSRGITRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLL
IGSSGLSGYVARLSSNSRINNNQYGTMQNLHDSCSRQLYVSLMLLYKTYGRKLHLYSH
PIVLGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHRE
SLYTAVTNFLLSLGIHLNPNKTKRWGYSLNFMGYIIGSWGTLPQDHIVQKIKHCFRKL
PVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQ
YMNLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARS
RSGAKLIGTDNSVVLSRKYTSFPWLLGCTANWILRGTSFVYVPSALNPADDPSRGRLG
LSRPLLRLPFQPTTGRTSLYAVSPSVPSHLPVRVHFASPLHVAWRPP"
geneorder（2854..3221,1..835）
/gene="preS1"
CDSjoin（2854..3221,1..835）
/gene="preS1"
/function="envelopeprotein"
/codon_start=1
/product="largesurfaceantigen"
/protein_id="CCC82740.1"
/db_xref="GI:
341823533"
/translation="MGGWSSKPRKGMGTNLSVPNPLGFFPDHQLDPAFGANSNNPDWD
FNPIKDHWPAANQVGVGAFGPGLTPPHGGILGWSPQAQGILTTVSTIPPPASTNRQSG
RQPTPISPPLRDSHPQAMQWNPTAFHQALQDPRVRGLYFPAGGSSSGTVNPAPNIASH
ISSISARTGDPVTNMENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGG
SPVCLGQNSQSPTSNHSPTSCPPICPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQG
MLPVCPLIPGSTTTSTGPCRTCTTPAQGNSMFPSCCCTKPTEGNCTCIPIPLSWAFAK
YLWEWASVRFSWLSLLVPFVQWFVGLSPTVWLSAIWMMWYWGPSLYSIVSPFIPLLPI
FFCLWVYI"
geneorder（3211..3221,1..835）
/gene="preS2"
CDSjoin（3211..3221,1..835）
/gene="preS2"
/function="envelopeprotein"
/codon_start=1
/product="middlesurfaceantigen"
/protein_id="CCC82741.1"
/db_xref="GI:
341823534"
/translation="MQWNPTAFHQALQDPRVRGLYFPAGGSSSGTVNPAPNIASHISS
ISARTGDPVTNMENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGGSPV
CLGQNSQSPTSNHSPTSCPPICPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLP
VCPLIPGSTTTSTGPCRTCTTPAQGNSMFPSCCCTKPTEGNCTCIPIPLSWAFAKYLW
EWASVRFSWLSLLVPFVQWFVGLSPTVWLSAIWMMWYWGPSLYSIVSPFIPLLPIFFC
LWVYI"
gene155..835
/gene="sAg"
CDS155..835
/gene="sAg"
/function="envelopeprotein"
/codon_start=1
/product="smallsurfaceantigen"
/protein_id="CCC82736.1"
/db_xref="GI:
341823529"
/translation="MENITSGFLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFLGG
SPVCLGQNSQSPTSNHSPTSCPPICPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQG
MLPVCPLIPGSTTTSTGPCRTCTTPAQGNSMFPSCCCTKPTEGNCTCIPIPLSWAFAK
YLWEWASVRFSWLSLLVPFVQWFVGLSPTVWLSAIWMMWYWGPSLYSIVSPFIPLLPI
FFCLWVYI"
gene1374..1838
/gene="X"
CDS1374..1838
/gene="X"
/function="putativetransactivatingprotein"
/codon_start=1
/product="HBx"
/protein_id="CCC86611.1"
/db_xref="GI:
342186698"
/translation="MAARLYCQLDPSRDVLCLRPVGAESRGRPLSGPLGTLSSPSPSA
VPADHGAHLSLRGLPVCAFSSAGPCALRFTSARCMETTVNAHQILPKVLHKRTLGLPA
MSTTDLEAYFKDCVFKDWEELGEEIRLKVFVLGGCRHKLVCAPAPCNFFTSA"
gene1814..2458
/gene="preC/C"
CDS1814..2458
/gene="preC/C"
/function="solublesecretedantigen"
/codon_start=1
/product="HBeAgprecursor"
/protein_id="CCC82737.1"
/db_xref="GI:
341823530"
/translation="MQLFHLCLIISCTCPTVQASKLCLGWLWGMDIDPYKEFGATVEL
LSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVG
NNLQDPASRDLVVNYVNTNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPA
YRPPNAPILSTLPETTVVRRRDRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC"
gene1901..2458
/gene="C"
CDS1901..2458
/gene="C"
/function="capsidprotein"
/codon_start=1
/product="cAg"
/protein_id="CCC82738.1"
/db_xref="GI:
341823531"
/translation="MDIDPYKEFGATVELLSFLPSDFFPSVRDLLDTASALYREALES
PEHCSPHHTALRQAILCWGELMTLATWVGNNLQDPASRDLVVNYVNTNMGLKIRQLLW
FHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRDRGRSPRR
RTPSPRRRRSQSPRRRRSQSRESQC"
2.HepatitisBviruscompletegenome,genotypeA2,isolateP5.9
GenBank:
HE576988.1
FASTAGraphics
Goto:
∙Features
∙Sequence
LOCUSHE5769883221bpDNAcircularVRL29-JUL-2011
DEFINITIONHepatitisBviruscompletegenome,genotypeA2,isolateP5.9.
ACCESSIONHE576988
VERSIONHE576988.1GI:
341823521
KEYWORDScompletegenome.
SOURCEHepatitisBvirus
ORGANISMHepatitisBvirus
Viruses;Retro-transcribingviruses;Hepadnaviridae;
Orthohepadnavirus.
REFERENCE1
AUTHORSMartel,N.,Cotte,L.,Trabaud,M.A.,Trepo,C.,Zoulim,F.,Gomes,S.
andKay,A.
TITLEGlucocorticoid-inducedreactivationofanoccultHBVinfectionin
anHIV+patient
JOURNALUnpublished
REFERENCE2（bases1to3221）
AUTHORSKay,A.C.
TITLEDirectSubmission
JOURNALSubmitted（22-JUL-2011）totheINSDC.KayA.C.,U1052,INSERM,151
coursAlbertThomas,Lyon,69003,FRANCE
FEATURESLocation/Qualifiers
source1..3221
/organism="HepatitisBvirus"
/mol_type="genomicDNA"
/serotype="ayw1"
/isolate="P5.9"
/db_xref="taxon:
10407"
/country="France"
/collection_date="09-Jun-2007"
/note="genotype:
A2"
geneorder（2307..3221,1..1623）
/gene="pol"
CDSjoin（2307..3221,1..1623）
/gene="pol"
/function="viralpolymerase"
/codon_start=1
/product="reversetranscriptase-DNApolymerase"
/protein_id="CCC82733.1"
/db_xref="GI:
341823525"
/translation="MPLSYQHFRKLLLLDDGTEAGPLEEELPRLADADLNRRVAEDLN
LGNLNVSIPWTHKVGNFTGLYSSTVPIFNPEWQTPSFPKIHLQEDIINRCQQFVGPLT
VNEKRRLKLIMPARFYPTHTKYLPLDKGIKPYYPDQVVNHYFQTRHYLHTLWKAGILY
KRETTRSASFCGSPYSWEQELQHGRLVIKTSQRHGDESFCSQPSGILSRSSVGPCIRS
QLKQSRLGLQPHQGPLASSQPGRSGSIRARAHPSTRRYFGVEPSGSGHIDHSVNNSSS
CLHQSAVRKAAHSHLSTSKRQSSSGHAVEFHCLPPSSAGSQSQGSVFSCWWLQFRNSK
PCSEYCLSHLVNLREDWGPCDEHGEHHIRTPRTPARVTGGVFLVDKNPHNTTESRLVV
DFSQFSRGITRVSWPKFAVPNLQSLTNLLSSNLSWLSLDVSAAFYHIPLHPAAMPHLL
IGSSGLSRYVARLSSNSRINNNQYGTMQNLHDSCSRQLYVSLMLLYKTYGRKLHLYSH
PIVLGFRKIPMGVGLSPFLLAQFTSAICSVVRRAFPHCLAFSYMDDVVLGAKSVQHRE
SLYTAVTNFLLSLGIHLNPNKTKRWGYSLNFMGYIIGSWGTLPQDHIVQKIKHCFRKL
PVNRPIDWKVCQRIVGLLGFAAPFTQCGYPALMPLYACIQAKQAFTFSPTYKAFLSKQ
YMNLYPVARQRPGLCQVFADATPTGWGLAIGHQRMRGTFVAPLPIHTAELLAACFARS
RSGAKLIGTDNSVVLSRKYTSFPWLLGCTANWILRGTSFVYVPSALNPADDPSRGRLG
LSRPLLRLPFQPTTGRTSLYAVSPSVPSHLPVRVHFASPLHVAWRPP"
geneorder（2854..3221,1..835）
/gene="preS1"
CDSjoin（2854..3221,1..835）
/gene="preS1"
/function="envelopeprotein"
/codon_start=1
/product="largesurfaceantigen"
/protein_id="CCC82734.1"
/db_xref="GI:
341823526"
/translation="MGGWSSKPRKGMGTNLSVPNPLGFFPDHQLDPAFGANSNNPDWD
FNPIKDHWPAANQVGVGAFGPGLTPPHGGILGWSPQAQGILTTVSTIPPPASTNRQSG
RQPTPISPPLRDSHPQAMQWNSTAFHQALQDPRVRGLYFPAGGSSSGTVNPAPNIASH
ISSISARTGDPVTNMENITSGLLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFQGG
SPVCLGQNSQSPTSNHSPTSCPPICPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQG
MLPVCPLIPGSTTTSTGPCRTCTTPAQGNSMFPSCCCTKPTEGNCTCIPIPSSWAFAK
YLWEWASVRFSWLSLLVPFVQWFVGLSPTVWLSAIWMMWYWGPSLYSIVSPFIPLLPI
FFCLWVYI"
geneorder（3211..3221,1..835）
/gene="preS2"
CDSjoin（3211..3221,1..835）
/gene="preS2"
/function="envelopeprotein"
/codon_start=1
/product="middlesurfaceantigen"
/protein_id="CCC82735.1"
/db_xref="GI:
341823527"
/translation="MQWNSTAFHQALQDPRVRGLYFPAGGSSSGTVNPAPNIASHISS
ISARTGDPVTNMENITSGLLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFQGGSPV
CLGQNSQSPTSNHSPTSCPPICPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQGMLP
VCPLIPGSTTTSTGPCRTCTTPAQGNSMFPSCCCTKPTEGNCTCIPIPSSWAFAKYLW
EWASVRFSWLSLLVPFVQWFVGLSPTVWLSAIWMMWYWGPSLYSIVSPFIPLLPIFFC
LWVYI"
gene155..835
/gene="sAg"
CDS155..835
/gene="sAg"
/function="envelopeprotein"
/codon_start=1
/product="smallsurfaceantigen"
/protein_id="CCC82730.1"
/db_xref="GI:
341823522"
/translation="MENITSGLLGPLLVLQAGFFLLTRILTIPQSLDSWWTSLNFQGG
SPVCLGQNSQSPTSNHSPTSCPPICPGYRWMCLRRFIIFLFILLLCLIFLLVLLDYQG
MLPVCPLIPGSTTTSTGPCRTCTTPAQGNSMFPSCCCTKPTEGNCTCIPIPSSWAFAK
YLWEWASVRFSWLSLLVPFVQWFVGLSPTVWLSAIWMMWYWGPSLYSIVSPFIPLLPI
FFCLWVYI"
gene1374..1838
/gene="X"
CDS1374..1838
/gene="X"
/function="putativetransactivatingprotein"
/codon_start=1
/product="HBx"
/protein_id="CCC86610.1"
/db_xref="GI:
342186697"
/translation="MAARLYCQLDPSRDVLCLRPVGAESRGRPLSGPLGTLSSPSPSA
VPADHGAHLSLRGLPVCAFSSAGPCALRFTSARCMETTVNAHQILPKVLHKRTLGLPA
MSTTDLEAYFKDCVFKDWEELGEEIRLKVFVLGGCRHKLVCAPAPCNFFTSA"
gene1814..2458
/gene="preC/C"
CDS1814..2458
/gene="preC/C"
/function="solublesecretedantigen"
/codon_start=1
/product="HBeAgprecursor"
/protein_id="CCC82731.1"
/db_xref="GI:
341823523"
/translation="MQLFHLCLIISCTCPTVQASKLCLGWLWGMDIDPYKEFGATVEL
LSFLPSDFFPSVRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMTLATWVG
NNLEDPASRDLVVNYVNNNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPA
YRP
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