pnca突变数据库.docx
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pnca突变数据库
ntposition
SNP
Codonposition
Amino
acid
Timeperiod
Resistance
pattern
Susceptibilitytestingmethod
Resistantisolates/Totalisolatestestedformutation
Resistant/Sensitiveisolateswithmutation
-16/-11
AACGTA/GGCAGTT
1999
Z
Proportionmethod
37/60
1/0
-12
T/G
1994-1997
Z
BACTEC460
36/44
1/0
-11
A/C
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
-11
A/G
1996
Z
BACTEC460
67/118
2/0
-7
T/C
1999
Z
Proportionmethod
37/60
1/0
1
del8bp
1
Frameshift
1996-1998
ZRHSE
Proportionmethod,BACTEC460
35/65
1/0
1
del11bp
1
Frameshift
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
2/0
2
ATG/ACG
1
Met/Thr
2000-2001
Z
BACTECMGIT960
55
55
3
ATG/ATT
1
Met/Ile
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
7
GCG/CCG
3
Ala/Pro
1986
ZHR
1/0
8
GCG/GAG
3
Ala/Glu
2006
Z
Proportionmethod,rapidbrothmethod
17/138
1/0
11
TTG/TGG
4
Leu/Trp
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
11
TTG/TCG
4
Leu/Ser
1999
Z
Proportionmethod
37/60
1/0
14
ATC/AGC
5
Ile/Ser
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
19
GTC/ATC
7
Val/Ile
1995,1996
ZHRPES
Proportionmethod
11/29
1/0
19
GTC/TTC
7
Val/Phe
1995,1996
ZHRPS
Proportionmethod
11/29
1/0
20
GTC/GGC
7
Val/Gly
1997
ZHRSE
Proportionmethod
33/168
2/0
20
GTC/GAC
7
Val/Asp
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
22
GAC/TAC
8
Asp/Tyr
1994-1997
Z
BACTEC460
36/44
1/0
23
GAC/GGC
8
Asp/Gly
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
24
GAC/GAG
8
Asp/Glu
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
26
GTG/GCG
9
Val/Ala
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
26
GTG/GGG
9
Val/Gly
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
26
GTG/TTG
9
Val/Leu
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
27
GTG/TCG
9
Val/Ser
1994-2004
Z
BACTECMGIT960
250
89
28
delC
10
Frameshift
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
28
CAA/AAA
10
Gln/Lys
1994-1997
Z
BACTEC460
36/44
1/0
28
CAA/TAA
10
Gln/STOP
1994-1997
Z
BACTEC460
36/44
1/0
29
CAG/CGA
10
Gln/Arg
1990-1992
ZHREO
Proportionmethod,BACTEC460
59/59
1/0
29
CAG/CCG
10
Gln/Pro
1997
ZHRSE
Proportionmethod
33/168
1/0
29
CAG/CCA
10
Gln/Pro
1999
Z
Proportionmethod
37/60
1/0
34
GAC/AAC
12
Asp/Asn
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
35
GAC/GCC
12
Asp/Ala
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
38
TTC/TCC
13
Phe/Ser
1987
ZHRES
19/35
1/0
40
TGC/CGC
14
Cys/Arg
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
40
TGC/CGC
14
Cys/His
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
41
TGC/TAC
14
Cys/Tyr
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
47
delG
16
Frameshift
1994-2004
Z
BACTECMGIT960
250
89
50
GGC/GAC
17
Gly/Asp
1997
ZHRS
Proportionmethod
33/168
2/0
50
GGC/GTC
17
Gly/Val
1994-2004
Z
BACTECMGIT960
250
89
52
insGG
Frameshift
ZHR
Proportionmethod,BACTEC460
59/59
1/0
56
CTG/CGG
19
Leu/Arg
1994-2004
Z
BACTECMGIT960
250
89
56
CTG/CCG
19
Leu/Pro
1996
Z
BACTEC460
67/118
1/0
62
GTA/GGA
21
Val/Gly
1994-2004
Z
BACTECMGIT960
250
89
64
delA
22
Frameshift
1994-2004
Z
BACTECMGIT960
250
89
59
delC
20
Frameshift
1996-1998
ZRSE
Proportionmethod,BACTEC460
35/65
1/0
68-69
GGT/GTC
23
Gly/Val
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
70
delG
24
Frameshift
1996
Z
BACTEC460
67/118
7/0
71
delG
24
Frameshift
1996-1998
ZRH
Proportionmethod,BACTEC460
35/65
1/0
74-75
GCC/GAA
25
Ala/Glu
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
77
GCG/GGG
26
Ala/Gly
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
84
delC
28
Frameshift
1994-1997
Z
BACTEC460
36/44
1/0
83
GCC/GAC
28
Ala/Asp
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
88-112
del24bp
Frameshift
1996-1999
Z
BACTECradiometrictesting
3/11
1/0
98-216
del118bp
Frameshift
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
100
insT
34
Frameshift
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
101
TAC/TCC
34
Tyr/Ser
1997
ZHRSE
Proportionmethod
33/168
2/0
104
CTG/CGG
35
Leu/Arg
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
109-110
GGA/TAA
37
Glu/STOP
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
106
del5.3kb
Frame/TRUNC
1999
Z
Proportionmethod
37/60
1/0
121
TAC/CAC
41
Tyr/His
1996-1998
ZHRE
Proportionmethod,BACTEC460
35/65
1/0
123
TAC/TAA
41
Tyr/STOP
1997
ZHRSE
Middlebrook7H11agarw/pHof6.0
33/168
1/0
123
TAC/TAG
41
Tyr/STOP
1996
Z
BACTEC460
67/118
1/0
128
CAC/CCC
43
His/Pro
1997
ZHR
Proportionmethod
33/168
1/0
134
GTG/GGG
45
Val/Gly
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
136
Gins
46
Frameshift
1997
ZHE
Proportionmethod
33/168
1/0
136
GCA/CCA
46
Ala/Pro
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
137
GCA/GAA
46
Ala/Glu
Z
Proportionmethod,BACTEC460
59/59
1/0
137
GCA/GTA
46
Ala/Val
Z
Proportionmethod,BACTEC460
59/59
1/0
139
ACC/CCC
47
Thr/Pro
1996-1998
ZRSE
Proportionmethod,BACTEC460
35/65
1/0
139
ACC/TCC
47
Thr/Ser
1994-1997
Z
BACTEC460
36/44
1/0
139
ACC/GCC
47
Thr/Ala
1996
Z
BACTEC460
67/118
11/0
145
GAC/CAC
49
Asp/His
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
146
GAC/GCC
49
Asp/Ala
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
146
GAC/GTC
49
Asp/Val
1994-1997
Z
BACTEC460
36/44
1/0
146
GAC/GGC
49
Asp/Gly
1994-1997
Z
BACTEC460
36/44
1/0
151
CAC/AAC
51
His/Asn
1998-2003
Z
Proportionmethod
59
40
151
CAC/TAC
51
His/Tyr
1999
Z
BACTEC460
23/62
1/0
151-230
del80bp
Frameshift
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
152
CAC/CCC
51
His/Pro
1997
ZHR
Proportionmethod
33/168
1/0
152
CAC/CGC
51
His/Arg
1997
ZHR
Proportionmethod
33/168
1/0
153
CAC/CAG
51
His/Gln
2006
Z
Proportionmethod,rapidbrothmethod
17/138
1/0
153
CAC/CAA
51
His/Gln
2006
Z
Proportionmethod,rapidbrothmethod
17/138
2/0
151
GAC/AAC
53
Asp/Asn
2006
Z
Proportionmethod,rapidbrothmethod
17/138
1/0
158
GAC/GCC
53
Asp/Ala
Z
Proportionmethod,BACTEC460
59/59
1/0
158
delA
53
Frameshift
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
160
CCG/ACG
54
Pro/Thr
1996
Z
BACTEC460
67/118
1/0
161
CCG/CTG
54
Pro/Leu
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
161
delC
54
Frameshift
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
162
insT
54
Frameshift
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
162
delG
54
Frameshift
MDR
7H9liquidmedium,pH5.6;PZaseactivityassayedaccordingtoWayne'smethod
4/7
1/0
169
CAC/TAC
57
His/Tyr
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
169
CAC/GAC
57
His/Asp
1996
Z
BACTEC460
67/118
2/0
170
CAC/CCC
57
His/Pro
2000
ZHRP
BACTECradiometric-basedculturemethod,standardprotocol;andPZaseactivity
13/18
1/0
170
CAC/CTC
57
His/Leu
1994-2004
Z
BACTECMGIT960
250
89
172
delT
58
Frameshift
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
172
TTC/CTC
58
Phe/Leu
1995-1996
ZHR
Proportionmethod
11/29
1/0
174
TTC/TTG
58
Phe/Leu
1997
ZHRS
Proportionmethod
33/168
1/0
175
TCC/CCC
59
Ser/Pro
2000
ZHRP
BACTEC460
13/18
1/0
181
ACA/CCA
61
Thr/Pro
1992
ZHRES
19/35
1/0
185
CCG/CAG?
?
62
Pro/His
1999
Z
BACTEC460
23/62
1/0
185
CCG/CGG
62
Pro/Arg
1999
Z
Proportionmethod
37/60
1/0
186
CCG/CTG
62
Pro/Leu
1994-2004
Z
BACTECMGIT960
250
89
188
GAC/GGC
63
Asp/Gly
1997
ZHRS
Proportionmethod
33/168
1/0
187
GAC/CAC
63
Asp/His
MDR
PZasetestwithWayne'smethod
4/7
1/0
190
TAT/GAT
64
Tyr/Asp
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
192
insA
64
Frameshift
1996
ZSHE
1/0
195-263
del68bp
Frameshift
1999
Z
BACTEC460
23/62
1/0
196
TCG/CCG
66
Ser/Pro
1994-1997
Z
BACTEC460
36/44
1/0
199
TCG/CCG
67
Ser/Pro
1997
ZHRSE
Proportionmethod
33/168
1/0
202
TGG/CGG
68
Trp/Arg
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
202
TGG/GGG
68
Trp/Gly
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
203
TGG/TCA
68
Trp/STOP
Z
Proportionmethod,BACTEC460
59/59
1/0
203
TGG/TCG
68
Trp/Ser
2001
Z
PZasetestwithWayne'smethod
92/95
1/0
203
TGG/TTG
68
Trp/Leu
1996
Z
BACTEC460
67/118
1/0
206
CCA/CGA
69
Pro/Arg
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
2/0
206
CCA/CGA
69
Pro/Arg
1996-1998
ZRHSE
Proportionmethod,BACTEC460
35/65
1/0
206
CCA/CTA
69
Pro/Leu
1994
ZHR
19/35
1/0
211
CAT/TAT
71
His/Tyr
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
212
CAT/GAT
71
His/Asp
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
212
CAT/CGT
71
His/Arg
1999
Z
Proportionmethod
37/60
1/0
213
CAT/CAG
71
His/Glu
ZHRS
Proportionmethod,BACTEC460
59/59
1/0
214
TGC/CGC
72
Cys/Arg
1992-1995
Z
PzasetestingbyWayne'smethod
46/46
1/0
215
TGC/TAC
72
Cys/Tyr
2001-2002
ZHRSEthK
BACTECMGIT960
115
68
216
TGC/TGG
72
Cys/Trp
2006
Z
Proportionmethod,rapidbrothmethod
17/138
1/0
215
ins29bp
Frameshift
1986
ZHRS
19/35
1/0
218
insCGCATTGCCG
Frameshift
2006
Z
Proportionmethod,rapidbrothmethod
17/138
1/0
221
insG
74
Frameshift
1999
Z
BACTEC460
23/62
2/0
224
ATG/ACG
75
Met/Thr
1994-2004
ZORH
BACTECMGIT960
89/250
1/0
226
ACT/CCT
76
Thr/Pro
1996
Z
BACTEC460
67/118
1/0
227
ACT/ATT
76
Thr/Ile
2000
ZHRP
BACTEC460
13/18
8/0
233
GGC/GAC
78
Gly/Asp
1999
Z
Proportionmethod
37/60
1/0
236
GCG/GGG
79
Ala/Gly
1994-2004
Z
BACTECMGIT960
250
89
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