帕金森病PD.ppt

帕金森病PD.ppt

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TND2005TND2005中华医生网收集http:

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/www.doctor-2.2.EpidemiologyEpidemiology3.3.RiskRiskfactorsfactors4.4.ClinicalClinicalfeaturesfeatures5.5.NeuropathologyNeuropathology6.6.FunctionalFunctionalneuroanatomyneuroanatomy7.7.NeurochemistryNeurochemistry8.8.TherapyTherapy9.9.DiagnosisDiagnosis10.10.SummarySummaryTND2005TND2005中华医生网收集http:

/www.doctor-in1817byin1817byananEnglishphysicianEnglishphysician,JamesParkinson,JamesParkinson,inin“An“AnEssayEssayontheontheShakingShakingPalsy.”Palsy.”ThefamousThefamousFrenchneurologistFrenchneurologist,CharcotCharcot,furtherfurtherdescribeddescribedthethesyndromesyndromeintheinthelatelate1800s.1800s.TND2005TND2005中华医生网收集http:

/www.doctor-Parkinson（1755-1824）,whilebestrememberedJamesParkinson（1755-1824）,whilebestrememberedforthediseasestatenamedafterhimbyCharcot,wasaforthediseasestatenamedafterhimbyCharcot,wasamanofmanytalentsandinterests.manofmanytalentsandinterests.TND2005TND2005中华医生网收集http:

/www.doctor-onchemistry,paleontologyandotherdiversetopics,hewas,earlyinhiscareer,asocialactivistchampioningtherightsofthedisenfranchisedandpoor.HiseffortsinthisareawereenoughtoresultinhisarrestandappearancebeforeThePrivyCouncilinLondononatleastoneoccasion.Incollaborationwithhisson,whowasasurgeon,healsoofferedthefirstdescription,intheEnglishlanguage,ofarupturedappendix.TND2005TND2005中华医生网收集http:

/www.doctor-THEONTHESHAKINGPALSYCHAPTERIDEFINITION-HISTORY-ILLUSTRATIVEDEFINITION-HISTORY-ILLUSTRATIVECASESCASESSHAKINGPALSY.（ParalysisAgitans.）MonographbyJamesParkinson1817JamesParkinsonTND2005TND2005中华医生网收集http:

/www.doctor-smallbutfamouspublication,EssayontheHissmallbutfamouspublication,EssayontheShakingPalsy,appearedin1817,7yearsbeforehisShakingPalsy,appearedin1817,7yearsbeforehisdeathin1824.deathin1824.TND2005TND2005中华医生网收集http:

/www.doctor-clinicaldescriptionof6patientswasaremarkablemasterpiecetestifyingtohisprodigiouspowersofobservationformostofthe6wereneveractuallyexaminedbyParkinsonhimself;rather,theyweresimplyobservedwalkingonthestreetsofLondon.TND2005TND2005中华医生网收集http:

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/www.doctor-lesslessprevalentprevalentinChinaandinChinaandotherotherAsianAsiancountriescountries,andin,andinAfrican-Americans.African-Americans.PrevalenceratesPrevalenceratesininmenmenareslightlyareslightlyhigherhigherthanthanininwomen;women;reasonreasonunknown,unknown,thoughthoughaaroleroleforforestrogenestrogenhashasbeenbeendebated.debated.TND2005TND2005中华医生网收集http:

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/www.doctor-ofParkinsonsEtiologyofParkinsonsEtiologyofParkinsonsEtiologyofParkinsonsDiseaseDiseaseDiseaseDiseaseDegenerationofthesubstantianigra（withLewybodies?

）ParkinsonsdiseasePARK-1（aa-Synuclein）PARK-2（Parkin）mitochondrialdysfuction?

oxidativestress?

geneticsusceptibiliesDebrisoquinhydroxylase?

PARK-5（UbiquitinCterminalhydrolaseL1）Toxins?

（MPTP,Rotenone）Neuroinflammation?

InfectionInfectionPARK-4（3xaa-Synuclein）PARK-7（DJ1）TND2005TND2005中华医生网收集http:

/www.doctor-Thebasalganglia,throughtheactionofThebasalganglia,throughtheactionofdopamine,areresponsibleforplanninganddopamine,areresponsibleforplanningandcontrollingautomaticmovementsofthecontrollingautomaticmovementsofthebody,suchaspointingwithafinger,body,suchaspointingwithafinger,pullingonasock,writingorwalking.Ifthepullingonasock,writingorwalking.Ifthebasalgangliaarenotworkingproperly,asbasalgangliaarenotworkingproperly,asinParkinsonsdiseasepatients,allaspectsinParkinsonsdiseasepatients,allaspectsofmovementareimpaired,resultingintheofmovementareimpaired,resultinginthecharacteristicfeaturesofthediseasecharacteristicfeaturesofthediseaseslownessofmovement,stiffnessandeffortslownessofmovement,stiffnessandeffortrequiredtomovealimband,often,tremor.requiredtomovealimband,often,tremor.TND2005TND2005中华医生网收集http:

/www.doctor-symptomssymptoms:

restingtremorbradykinesia（generalizedslownessofmovements）musclerigidityTND2005TND2005中华医生网收集http:

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AsymmetriclesionsTND2005TND2005中华医生网收集http:

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