试题集免疫学试题A卷及答案Word文档格式.docx

试题集免疫学试题A卷及答案Word文档格式.docx

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3.cytokine

4.MHCrestriction

5.PRR

6.Immunetolerance

7.ITAM

**

9.TI-Ag

II.Chooseallcorrectanswers（1pointforeach,15points）

No.

1

2

3

4

5

6

7

8

Answer

9

10

11

12

13

1.Whichofthefollowingstatement（s）aboutthespleenis（are）true:

A.Itfiltersantigensoutoftheblood.

B.Lymphaticvesselsdrainingthetissuespacesenterthespleen

C.Itcontainsgerminalcenters

D.Itfunctionstoremoveoldanddefectiveredbloodcells

**kindsofIgexpressedmainlyonthesurfaceofmatureBcells?

A.mIgGB.mIgAC.mIgDD.mIgM

**canfunctionasC3convertaseinactivationofcomplementsystem?

**B.C4b2b3bC.C3bBbD.C3bnBb

**thecharacteristicsofcytokines,whichofthefollowing（s）is（are）correct?

A.Onecytokinecanactondifferentcellsandplaymultiplebiologicaleffects

B.Thecytokineproducedbyonecellonlyactsonneighborcells

C.Combinedwithcorrespondingreceptortoplayrole

D.Onecytokinecaninhibitorenhanceeffectsofothercytokine

**ofthefollowingmoleculescanstimulateTcellsactivation?

A.LPSB.PWMC.ConAD.PHA

**arethefunctionsofBcells?

A.produceAb

B.secretecytokines

C.killtargetcellsdirectly

D.presentAg

**ofthecytokinesaresecretedbyTh1cells?

A.IL-4B.IL-2C.IL-10D.IFN-γ

**ofthediseasesbelongtotypeⅢhypersensitivity?

A.Transfusionreaction

B.Arthusreaction

C.Contactdermatitis

D.Rheumatoidarthritis

**ofthefollowingis（are）correctaboutthecharacteristicsofmemorycells?

A.**efromeitherBcellorTcell

B.Canrespondtoantigenatlowconsentrateeffectivelly

C.OnlyexistinHI

D.Reacttoasecondinvasionofanantigenmorerapidlyandstronger

**abilitiesdoαβ+Tcellsgainaftermaturation?

A.self-reactive

B.self-tolerance

C.expressfunctionalTCR

D.selfMHCrestriction

**ofthefollowingsarecorrectstatementsaboutdendriticcells?

A.Canstimulatenaï

veTcellproliferation

B.ExpresshighlevelofMHCclassIImolecules

C.ExpresshighlevelofMHCclassImolecules

D.Maturedendriticcellswithstrongfunctionofantigen-capture

**AICD,whichstatementsarecorrect?

A.CanbemediatedbyFasL-Fasinteraction

B.IsakindofcelldeathofactivatedTcell

C.Playimportantrolesinimmunologicalregulation

D.IL-4canpromoteAICD

13.Theprocessesofantigen-activatedBcellsdifferentiationingerminalcenterinclude:

A.IgClassswitching

B.SomatichypermutationandIgaffinitymaturation

C.DifferentiateintoBm

D.Apoptosis

**ofthefollowingfactorsaffecttheantigenimmunogenecity?

A.moleculeweightB.foreigness

C.conformationD.**position

15.Aboutsomatichypermutation,whichstatementsarecorrect?

A.OccursduringBcellsmaturation

B.Resultinaffinitymaturationofantibodies

C.MainlyoccursinCDRregion

D.CanoccurduringTcellsmaturation

Ⅲ．Answerthefollowingquestionsbriefly（5pointforeach,30points）

1.HowcanThelpercellsplayimportantrolesinanantibodymediatedresponse.

**cellsexpresstheHLAIImolecules?

WhatarethefunctionsofHLAIImoleculesonthesecells?

**wewanttolabeltheantibodywithenzymeforELISAexperiment,whatpartofantibodydoesenzymeshouldbindto?

Why?

**doeffectorspecificCTLskilltumorcells?

Whatarethecharacteristicsforthisprocess?

5.HowareendogenousantigensrecognizedbyCD8+Tcells?

6.WhatisNeonatehemolysis?

Pleasedescribeitsmechanism.

IV.Answerfollowingquestion（12points）

1.Howtheinnateandadaptiveimmunityactincooperativeandinter-dependentwaystoprotectthehost.?

**recirculation:

istheprocessbywhichlymphocytescontinuouslymovebetweensitesthroughoutthebody

（1）throughbloodandlymphaticvessels,anditiscriticalfortheinitiationandeffectorphasesofimmuneresponses

（1）.

2.CDR:

Complementarity-determiningregion（0.5）

thethreeHVRofLchainandHchainarebroughttogethertoformantigen-bindingsurface,soHVRisalsocalledCDR

（1）

3.cytokine:

Agroupof（0.5）lowmoleculeweightproteins（0.5）whicharesecretedbyactivatedimmunocytesorsomematrixcells（0.5）andtakeeffectsbybindingcorrespondingreceptoroncells（0.5）.

**restriction:

IninteractionofTcellandantigen-presentingcell（APC）ortargetcell（0.5）,Tcellnotonlyrecognizesspecificantigenpeptide,butalsorecognizespolymophicresidueofMHCmolecules（0.5）.

5.Patternrecognitionreceptor（PRR）:

Thereceptoronmacrophage（0.5）whichcanrecognizeandbindspecificmolecularstructureonsomepathogens,injuredorapoptoticcells（0.5）.

aspecificnonreactivity1.0

towardsagivenantigen0.5

inothercircumstanceisabletoinducecell-mediatedorhumoralimmunity0.5

immunoreceptortyrosine-basedactivationmotif0.5

transductactivationsignal1.0

composedoftwotyrosineresiduesseparatedbyaround18aminoacid-----whenantigenbinds,thetyrosinebecomephosphorylatedbythereceptorassociatedtyrosinekinasestotransductactivatorysignal0.5

cellsthatcancapture（0.5）,processantigen（0.5）,andpresenttheantigenicpeptide/MHCclassIorIImolecules（0.5）toTcells（0.5）arecalledantigen-presentingcells.TheyarealsocalledAcell（Accessorycell）.

9.TI-Ag（thymusindependentAg）:

AgwhichcanstimulateBcellstoproduceAb（0.5）withoutthehelpofTcellandMФ（0.5）.

II.Chooseallcorrectanswers（1pointforeach,15points）

ACD

CD

AC

BCD

ABD

BD

14

15

ABC

ABCD

（1）ExpressCD40L（0.5）,combinewithCD40expressingonBcell（0.5）,provideco-stimulationsignalduringtheactivationofBcell

（1）.

（2）SecreteIL-4,5,6（0.5）etc.topromoteproliferationanddifferentiationofBcell

（1）

（3）SecretecytokinestopromoteIgisotypeswitching（1.5）.

cellsexpresstheHLAIImolecules

（2）

professionalAPC（macrophage,dentriticcellandBcell）,

activatedTcell,

thymusepithelialcelletal.

thefunctionsofHLAIImolecules（1pointeach）

Ø

ParticipateincontrollingThcell-APCrecognitioninimmunoreaction

Participateinprocessingandpresentingofantigen

ParticipateininducingthedifferentiationanddevelopmentofTcellinthymus

Fcfragment

（2）,because:

FabbindstoAgspecifically

（1）

FchasnoeffectonAgbinding,soFccanbelabeledtodetectAg-AbcomplexwithouteffectiononitsAgbindingactivity

（2）

•**doeffectorspecificCTLskilltumorcells?

SpecificrecognitionandbindingoftargetcellbyCTL

•Lethalhittotargetcell

•Perforin1

•Granzyme1

•Fas/FasLpathway—apoptosis0.5

•Specifickilling1

•classⅠMHCmoleculerestriction1

•Continuouskillingoftargetcellsinshorttime,andnoinjuryofCTL0.5

◆ByclassIMHCpathway1

◆ProcessingofendogenousAg：

proteosome-LMP2,LMP7，antigenpeptides（8-13aa）1

◆TransportingofantigenpeptideintoER：

TAP（transporterassociatedwithantigenprocessing）1

◆PeptideloadingofMHCImolecules：

ER，antigenpeptide—classⅠ**plexes1

PresentingtoCD8+Tcells：

TCR-peptide,CD8-α31

Definition:

MaternalIgGspecificforthefetalbloodgroupscrossestheplacentaanddestroysthefetalredbloodcells1

Mechanism:

MainlyinducedbyRhantigen.ItisTypeIIhypersensitivity0.5

RhantigensonthesurfaceoffetalredbloodcellsinduceIgGantibodyproductionwithinmotherbody---thefirstpregnancy.1

IgGcrossestheplacentaandbindwithRhantigentoformAg-Abcomplex---thesecondpregnancy.1

Celllysis:

Ag-Abcomplex**plementbyclassicpathway.

MAC0.5

ADCC0.5

OposinizationbyCandAbpromotesmacrophagesfunction.0.5

1.Howdotheinnateandadaptiveimmunityactincooperativeandinter-dependentwaystoprotectthehost?

Innateimmunity→adaptiveimmunity（8points）

（1）macrophageandDCparticipateinantigenicpresentationandinitiateadaptiveimmunity3points

（2）macrophage,NK,Complementetc.participateineffectorphageofadaptiveimmunity3points

（3）macrophageandNKsecretecytokinesregulatetypesofadaptiveimunity2points

Adaptiveimmunity→Innateimmunity（4points）

（1）Ab-Agcomplexsitumulateactivationofcomplementbyclassicalpathway1points

（2）ActivatedTcellssecretecytokinestoparticipateininnateimmunity1points

（3）ActivatedTcellssecretecytokinestoactivateNK