试题集免疫学试题A卷及答案Word文档格式.docx

1、3. cytokine 4. MHC restriction5. PRR 6. Immune tolerance7. ITAM*9. TI-AgII. Choose all correct answers （1 point for each,15 points）No.12345678Answer9101112131. Which of the following statement（s） about the spleen is（are） true:A. It filters antigens out of the blood.B. Lymphatic vessels draining the

2、tissue spaces enter the spleenC. It contains germinal centersD. It functions to remove old and defective red blood cells * kinds of Ig expressed mainly on the surface of mature B cells?A. mIgG B. mIg A C. mIgD D.mIgM* can function as C3 convertase in activation of complement system?* B.C4b2b3b C.C3b

3、Bb D.C3bnBb* the characteristics of cytokines, which of the following（s） is （are） correct?A. One cytokine can act on different cells and play multiple biological effects B. The cytokine produced by one cell only acts on neighbor cells C. Combined with corresponding receptor to play roleD. One cytoki

4、ne can inhibit or enhance effects of other cytokine* of the following molecules can stimulate T cells activation?A. LPS B. PWM C. Con A D. PHA * are the functions of B cells?A. produce AbB. secrete cytokinesC. kill target cells directlyD. present Ag* of the cytokines are secreted by Th1 cells?A. IL-

5、4 B. IL-2 C. IL-10 D. IFN-* of the diseases belong to type hypersensitivity?A. Transfusion reactionB. Arthus reactionC. Contact dermatitisD. Rheumatoid arthritis* of the following is（are） correct about the characteristics of memory cells?A. *e from either B cell or T cellB. Can respond to antigen at

6、 low consentrate effectivellyC. Only exist in HID. React to a second invasion of an antigen more rapidly and stronger* abilities do +T cells gain after maturation?A. self-reactiveB. self-toleranceC. express functional TCRD. self MHC restriction * of the followings are correct statements about dendri

7、tic cells?A. Can stimulate nave T cell proliferationB. Express high level of MHC class II moleculesC. Express high level of MHC class I moleculesD. Mature dendritic cells with strong function of antigen-capture * AICD, which statements are correct?A. Can be mediated by FasL-Fas interactionB. Is a ki

8、nd of cell death of activated T cellC. Play important roles in immunological regulationD. IL-4 can promote AICD13. The processes of antigen-activated B cells differentiation in germinal center include:A. Ig Class switchingB. Somatic hypermutation and Ig affinity maturationC. Differentiate into BmD.

9、Apoptosis* of the following factors affect the antigen immunogenecity?A. molecule weight B. foreignessC. conformation D. *position15. About somatic hypermutation, which statements are correct?A. Occurs during B cells maturationB. Result in affinity maturation of antibodiesC. Mainly occurs in CDR reg

10、ionD. Can occur during T cells maturationAnswer the following questions briefly （5 point for each, 30 points）1. How can T helper cells play important roles in an antibody mediated response.* cells express the HLA II molecules? What are the functions of HLA II molecules on these cells?* we want to la

11、bel the antibody with enzyme for ELISA experiment, what part of antibody does enzyme should bind to? Why?* do effector specific CTLs kill tumor cells? What are the characteristics for this process?5. How are endogenous antigens recognized by CD8+ T cells?6. What is Neonate hemolysis? Please describe

12、 its mechanism.IV. Answer following question （12 points）1. How the innate and adaptive immunity act in cooperative and inter-dependent ways to protect the host.?* recirculation: is the process by which lymphocytes continuously move between sites throughout the body（1） through blood and lymphatic ves

13、sels, and it is critical for the initiation and effector phases of immune responses（1）.2. CDR: Complementarity-determining region （0.5） the three HVR of L chain and H chain are brought together to form antigen-binding surface, so HVR is also called CDR（1）3. cytokine: A group of（0.5） low molecule wei

14、ght proteins（0.5） which are secreted by activated immunocytes or some matrix cells（0.5） and take effects by binding corresponding receptor on cells（0.5）. * restriction: In interaction of T cell and antigen-presenting cell（APC） or target cell（0.5） ,T cell not only recognizes specific antigen peptide,

15、 but also recognizes polymophic residue of MHC molecules（0.5）.5. Pattern recognition receptor（PRR）: The receptor on macrophage（0.5） which can recognize and bind specific molecular structure on some pathogens , injured or apoptotic cells（0.5）. a specific nonreactivity 1.0towards a given antigen 0.5in

16、 other circumstance is able to induce cell-mediated or humoral immunity 0.5 immunoreceptor tyrosine-based activation motif 0.5transduct activation signal 1.0composed of two tyrosine residues separated by around 18 amino acid-when antigen binds, the tyrosine become phosphorylated by the receptor asso

17、ciated tyrosine kinases to transduct activatory signal 0.5 cells that can capture（0.5）, process antigen （0.5）, and present the antigenic peptide/MHC class I or II molecules（0.5） to T cells （0.5） are called antigen-presenting cells. They are also called A cell （Accessory cell）.9. TI-Ag （thymus indepe

18、ndent Ag） : Ag which can stimulate B cells to produce Ab（0.5） without the help of T cell and M（0.5）. II. Choose all correct answers （1 point for each, 15 points）ACDCDACBCDABDBD1415ABCABCD（1） Express CD40L（0.5）,combine with CD40 expressing on B cell（0.5）,provide co-stimulation signal during the activ

19、ation of B cell（1）.（2） Secrete IL-4,5,6（0.5） etc. to promote proliferation and differentiation of B cell（1）（3） Secrete cytokines to promote Ig isotype switching（1.5）.cells express the HLA II molecules （2） professional APC（macrophage, dentritic cell and B cell）, activated T cell, thymus epithelial ce

20、ll et al.the functions of HLA II molecules （1 point each）Participate in controlling Th cell- APC recognition in immunoreactionParticipate in processing and presenting of antigenParticipate in inducing the differentiation and development of T cell in thymusFc fragment（2）,because:Fab binds to Ag speci

21、fically（1）Fc has no effect on Ag binding, so Fc can be labeled to detect Ag-Ab complex without effection on its Ag binding activity（2） * do effector specific CTLs kill tumor cells?Specific recognition and binding of target cell by CTL Lethal hit to target cell Perforin 1Granzyme 1Fas/FasL pathwayapo

22、ptosis 0.5Specific killing 1classMHC molecule restriction 1Continuous killing of target cells in short time, and no injury of CTL 0.5By class I MHC pathway 1Processing of endogenous Ag：proteosome -LMP2, LMP7，antigen peptides（8-13aa） 1Transporting of antigen peptide into ER：TAP（transporter associated

23、 with antigen processing） 1Peptide loading of MHC I molecules：ER，antigen peptideclass *plexes 1Presenting to CD8+T cells：TCR-peptide, CD8-3 1Definition: Maternal IgG specific for the fetal blood groups crosses the placenta and destroys the fetal red blood cells 1Mechanism:Mainly induced by Rh antige

24、n. It is Type II hypersensitivity 0.5Rh antigens on the surface of fetal red blood cells induce IgG antibody production within mother body-the first pregnancy. 1IgG crosses the placenta and bind with Rh antigen to form Ag-Ab complex-the second pregnancy. 1Cell lysis: Ag-Ab complex *plement by classi

25、c pathway. MAC 0.5ADCC 0.5Oposinization by C and Ab promotes macrophages function. 0.51. How do the innate and adaptive immunity act in cooperative and inter-dependent ways to protect the host?Innate immunity adaptive immunity（ 8 points）（1）macrophage and DC participate in antigenic presentation and

26、initiate adaptive immunity 3 points（2）macrophage,NK,Complement etc. participate in effector phage of adaptive immunity 3 points（3）macrophage and NK secrete cytokines regulate types of adaptive imunity 2 pointsAdaptive immunityInnate immunity（4 points）（1）Ab-Ag complex situmulate activation of complement by classical pathway 1 points（2）Activated T cells secrete cytokines to participate in innate immunity 1 points（3）Activated T cells secrete cytokines to activate NK