sci审稿意见回复范文.docx

sci审稿意见回复范文.docx

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sci审稿意见回复范文

论文题目：

PharmacokineticandpharmacodynamicstudiesontheantiviruseffectsofA（一种中草药）againstvirusB（一种病毒）

所投杂志：

LifeSciences

投稿结果：

这次大修后又经过一次小修，被接受发表

编辑信内容（注：

有删节）：

DearMr.XXX,

Yourmanuscripthasbeenexaminedbytheeditorsandqualifiedreferee.WethinkthemanuscripthasmeritbutrequiresrevisionbeforewecanacceptitforpublicationintheJournal.Carefulconsiderationmustbegiventothepointsraisedinthereviewercomments,whichareenclosedbelow.

Ifyouchoosetosubmitarevisionofyourmanuscript,pleaseincorporateresponsestothereviewercommentsintotherevisedpaper.

Acompleterebuttalwithnomanuscriptalterationsisusuallyconsideredinadequateandmayresultinlengthyre-reviewprocedures.

Aletterdetailingyourrevisionspoint-by-pointmustaccompanytheresubmission.

YouwillberequestedtouploadthisResponsetoReviewersasaseparatefileintheAttachFilesarea.

Weaskthatyouresubmityourmanuscriptwithin45days.Afterthistime,yourfilewillbeplacedoninactivestatusandafurthersubmissionwillbeconsideredanewmanuscript.

Tosubmitarevision,gotoandloginasanAuthor.

YouwillseeamenuitemcalledSubmissionNeedingRevision.Youwillfindyoursubmissionrecordthere.

Yourssincerely,

JosephJ.Bahl,PhD

Editor

LifeSciences

FormatSuggestion:

PleaseaccesstheGuidetoAuthorsatourwebsitetochecktheformatofyourarticle.PayparticularattentiontoourReferencesstyle.

Reviewers'comments:

Reviewer#1:

XXXXX（略）

Reviewer#2:

XXXXX（略）

Editorsnoteandsuggestions:

（注：

编辑的建议）

Title:

Re-writethetitletoreadmoresmoothlyincontemporaryEnglish>>>

PharmacokineticandpharmacodynamicstudiesoftheantiviraleffectsofAagainstvirusB.

Abstract:

Re-writetheabstracttoreadmoresmoothly.

A,analkaloidisolatedfromC（注：

一种中草药）,wastestedfor

antiviralactivityagainstvirusB.BothinvitroandinvivoassaysalongwithserumpharmacologicalexperimentsshowedAtohavepotentantiviralactivity.ThepharmacokineticprofileofAinSprague/DawleyratplasmaafteroraladministrationwasmeasuredbyHPLC.Bloodsamplestakenatselectedtimepointswereanalyzedtostudypotentialchangesinantiviralpharmacodynamicsasmeasuredbyinfectivityofviruses.FromthesimilarityoftheserumconcentrationprofilesandantiviralactivityprofilesitisconcludedthatAitself,ratherthanametabolite,exertedtheeffectagainsttheviruspriortobioinactivation.TheneedforeffectiveclinicalagentsagainstvirusBandtheseresultssuggestthepossibilityofbenefitfromfurtherexperimentswithA.

Theauthorsshouldchecktobesurethatthetermsbloodsamples,plasmaandserumarealwaysusedappropriatelythroughouttheabstractandtext.

Introduction:

somesentencescanbemadelesspassive.example1stparagraph

>>>>Aappearstobethemostimportantalkaloidisolatedfromtheplant,itsstructuralformulaisshowninFig1Whileitproduced

ageneralinhibitionofantibodyproductionlymphocyteproliferationwasstimulated（XiaandWang,1997）.ThesepharmacologicalpropertiessuggestapotentialuseinthetreatmentofviralmyocarditisagainstvirusBthatcouldbestudiedinexperimentsincellcultureandanimals.

>>>Theauthorsshouldchecktheentiremanuscriptforspellingerrors（examplegiven:

inyourtextalkaloidisincorrectlyspelledalkaloid）

>>>Theauthorsshouldreadtheguidelinestotheauthorsandnotincludethefirstnameoftheauthorsbeingcitedinthetext.Inthe

referencesectionthefirstnameshouldbeabbreviatedasshownintheguidelinetoauthors（thustheearliertextreferenceshouldbe（Liuetal.,2003）andtheremainingoneshouldbe（Chenetal.,2002）

>>>>>Theauthorsinsteadofdirectlyansweringthefirstcomplexquestionofreviewer#1mayincludethethreequestionsasfutureresearchaiminthediscussionsection.

>>>>>>Ratherthanredrawingfiguretheauthorsmaychoosetoamendthewordingofthestatisticalanalysissectiontostatethattheresultoftablesaremeans+-SEMandforfiguresare+-SD.

>>>>>reviewer#1commentnumber8andreviewer#2comment3mightbesatisfiedbyinclusionofarepresentativephotoofcellsandheartshowingCPE.Remembermostreadersofthejournalhaveneverseenwhatyouaretryingtodescribe.

BecauseIthinkthatyoucandealwithallofthepointsraisedIamhopingtoseearevisedmanuscriptthatyouhavecarefullycheckedforerrors.IfyouhavequestionsordonotknowhowtorespondtoanyofthepointsraisedpleasecontactmeatJosephBahl,PhDEditor2LifeSciences作者回复信原稿：

DearDr.Bahl,

I’m（注：

正式信函不要简写）veryappreciate（注：

不适合作为给编

辑回信的开始，同时有语法错误）foryourcommentsandsuggestions.

I（注：

实际上是学生做的）haveconductedinvivoantivirusexperiments

again（注：

要表明是应审稿人或编辑建议而作）.Miceweresacrificedon15

daysand30daysafterinfection.Deathrate,heartweighttobodyweightratio（HW/BW）,virustitersandpathologicslices（注：

用词错误）were

calculated（注：

用词不当）.ProductionofmRNAofIL-10,IFN-γandTNF-

αwere（注：

语法错误）measuredbyRT-PCR.

Ihaverevisedthismanuscriptandespeciallypaidmuchattentiontoyourcommentsandsuggestions.Iwouldliketore-submitittoLIFESCIENCE.Titleofmanuscripthasbeenchangedto“TheantiviruseffectsofAagainstvirusBanditspharmacokineticbehaviourinSDratsserum”tomakeitmoreclearandsmooth.

AnswerstoReviewers’questionswereasfollows:

（注：

可附在给编

辑的回复信后）

Reviewer#1:

XXXXX

Reviewer#2:

XXXXX

Editorsnoteandsuggestions:

Title:

Re-writethetitletoreadmoresmoothlyincontemporaryEnglish

Answer:

Ihaverewritethetitleto“TheantiviruseffectsofA

againstvirusBanditspharmacokineticbehaviourinSDratsserum”to

makeitmoreclearandsmooth（注：

多处语法错误）.

Abstract:

Re-writetheabstracttoreadmoresmoothly.

Answer:

Ihaverevisetheabstractcarefullytomakeitmoresmoothandinformative（注：

语法错误）.

Theauthorsshouldchecktobesurethatthetermsbloodsamples,plasmaandserumarealwaysusedappropriatelythroughouttheabstractandtext.

Answer:

Ihavepaidattentiontothisquestionanditisclearer（注：

不具体）.

Introduction:

somesentencescanbemadelesspassive.

Answer:

IhaverevisethewholepapertomakesentenceslesspassiveandobtainedhelpofmycolleagueproficientinEnglish（注：

语法错误，

句子不通顺）.

Theauthorsshouldchecktheentiremanuscriptforspellingerrors

Answer:

I’mverysorrytogiveyousomuchtroubleforthosespellingerrors（注：

不必道歉，按建议修改即可）.Ihavecarefullycorrectedthem.

Theauthorsshouldreadtheguidelinestotheauthorsandnotincludethefirstnameoftheauthorsbeingcitedinthetext.Inthereferencesectionthefirstnameshouldbeabbreviatedasshownintheguidelinetoauthors（thustheearliertextreferenceshouldbe（Liuetal.,2003）andtheremainingoneshouldbe（Chenetal.,2002）

Answer:

Ichangedthestyleofreferences.

Ratherthanredrawingfiguretheauthorsmaychoosetoamendthewordingofthestatisticalanalysissectiontostatethattheresultoftablesaremeans+-SEMandforfiguresare+-SD.

Answer:

（注：

作者请编辑公司帮回答）

reviewer#1commentnumber8andreviewer#2comment3mightbesatisfiedbyinclusionofarepresentativephotoofcellsandheart

showingCPE.Remember:

mostreadersofthejournalhaveneverseenwhatyouaretryingtodescribe.

Answer:

Thankyouforyoursuggestions.Ihavesupplementedpicturesofcardiacpathologicslicesinthepaper（Fig2）.

Ihavetoapologizeforgivingyousomuchtroublebecauseofthosemisspellingandconfusingstatements（注：

一般不是延误或人为失误，不

必轻易道歉，按建议修改即可）.Yourcommentsandsuggestionsreallyhelped

mealot.Ihaveputgreateffortstothisreview.Iwishitcanbesatisfactory.

Ifthere’s（注：

正式信函不要简写）anyinformationIcanprovide,

pleasedon’thesitatetocontactme.

Thankyouagainforyourtimeandpatience.Lookforwardtohear（注：

语法错误）fromyou.

YoursSincerely

XxxxXxxx（通讯作者名）

建议修改稿：

DearDr.Bahl,

Thanksyouverymuchforyourcommentsandsuggestions.

Assuggested,wehaveconductedinvivoantivirusexperiments.Miceweresacrificedon15daysand30daysafterinfectionwithvirusB.

Mortality,heartweighttobodyweightratio（HW/BW）,virustitersandpathologicscoresweredetermined.Inaddition,mRNAexpressionofIL-10,IFN-γandTNF-αweremeasuredbyRT-PCR.

Wehaverevisedthemanuscript,accordingtothecommentsandsuggestionsofreviewersandeditor,andresponded,pointbypointto,thecommentsaslistedbelow.Sincethepaperhasbeenrevisedsignificantlythroughoutthetext,wefeelitisbetternottohighlighttheamendmentsintherevisedmanuscript（正常情况最好表明修改处）.

TherevisedmanuscripthasbeeneditedandproofreadbyamedicaleditingcompanyinHongKong.

Iwouldliketore-submitthisrevisedmanuscripttoLifeSciences,andhopeitisacceptableforpublicationinthejournal.

Lookingforwardtohearingfromyousoon.

Withkindestregards,

YoursSincerely

XxxxXxxx（通讯作者名）

RepliestoReviewersandEditor

Firstofall,wethankbothreviewersandeditorfortheirpositiveandconstructivecommentsandsuggestions.

RepliestoReviewer#1:

Xxxxx（略）

RepliestoReviewer#2:

Xxxxx（略）

RepliestotheEditorsnoteandsuggestions:

Title:

Re-writethetitletoreadmoresmoothlyincontmeporaryEnglish

Answer:

Ihaverewritethetitleto“TheantiviruseffectsofSophoridineagainstCoxsackievirusB3anditspharmacokineticsinrats”tomakeitmoreclearandreadmoresmoothly.

Abstract:

Re-writetheabstracttoreadmoresmoothly.

Answer:

Ihaverewrittentheabstracttomakeitmoreinformativeandreadmoresmoothly.

Theauthorsshouldchecktobesurethatthetermsbloodsamples,plasmaandserumarealwaysusedappropriatelythroughouttheabstract