胰岛素抵抗.docx

胰岛素抵抗.docx

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胰岛素抵抗

Christopher Gardner

Title:

WhichDietisBestforWeightLossinInsulinResistantIndividuals?

DirectorofNutritionStudiesatStanfordPreventionResearchCenter;AssociateProfessorofMedicineatStanfordUniversityandCHP/PCORAssociate

HooverPavilion,Room403

211QuarryRoad

Stanford,CA94305

cgardner@stanford.edu

ChristopherD.Gardner,PhD,istheDirectorofNutritionStudiesattheStanfordPreventionResearchCenterandanAssociateProfessorofMedicineatStanfordUniversity.HereceivedhisPhDinNutritionalSciencesattheUniversityofCalifornia,Berkeleyin1993.HispostgraduatetrainingincludedapostdoctoralfellowshipincardiovasculardiseaseepidemiologyatStanford.

Dr.Gardnerisactivelyinvolvedinresearchandteaching.Hisresearchfocusisondietaryinterventiontrialsdesignedtotesttheeffectsoffoodcomponentsorfoodpatternsonchronicdiseaseriskfactors,includingbodyweight,bloodlipids,andinflammatorymarkers.Hehaspublishedextensivelyinpeer-reviewedjournals,includingarecentpublicationinJAMApresentinghisfindingsfromastudycontrastingtheweightlosseffectsoffourdietsrangingfromverylowtoveryhighcarbohydrate.Hespeaksnationallywithinhisareasofexpertise,whichinclude:

Dietaryapproachestoimprovebloodlipids,weightlossdiets,healthbenefitsofvegetarianandplant-baseddiets,theoptimaldietforcardiovascularhealth,dietarysupplements,andcomplementaryandalternativemedicine.

AssociateProfessor（Research）,Medicine-StanfordPreventionResearch

Member,CancerCenter

Contact Information

AcademicOffices

PersonalInformation

Emailcgardner@stanford.eduTel（650）725-2751

AdministrativeContact

TraciHareAdministrativeAssociateEmailtraci.hare@stanford.eduTelWork721-1057

Professional Overview

AdministrativeAppointments

EducationCommittee,TheObesitySociety（2009-2011）

NutritionCommittee,AmericanHeartAssociation（2009-2011）

HonorsandAwards

TeachingAward,StanfordPreventionResearchCenter（2005）

DistinguishedHonoraryAward,SanJoseStateUniversityDepartmentofNutrition（2003）

RegentsFellowship,Univ.Cal.Berkeley（1988）

ProfessionalEducation

B.A.:

ColgateUniversity,Philosophy（1981）

PhD:

UnivCalBerkeley,NutritionScience（1993）

PostdoctoralAdvisees

FarshadFaniMarvasti,AriannaMcClain,JenniferOtten,MaryRosenberger,AbuTaiyabMd.NazmusSaquib,VeronicaYank

InternetLinks

SPRCFaculty-CGardner

Scientific Focus

CurrentResearchInterests

Theroleofnutritionandpreventivemedicine,withparticularinterestsin:

plant-baseddietsandphytochemicals;cardiovasculardiseaseandcancerprevention;weightlossdiets;clinicaltrialsandepidemiology.

ClinicalTrials

EffectsofRawvs.OtherMilkSourcesonLactoseDigestionRecruiting

AddingSleepInterventiontoTraditionalDietandExerciseApproachtoWeightLossCompleted

EffectofFishOilonPlasmaTriglyceridesinAdultsCompleted

EffectsofDietaryAntioxidantsonCardiovascularRiskFactorsCompleted

EffectsofOmega-3FattyAcidsonMarkersofInflammationCompleted

Publications

ComparisonoftheAtkins,Zone,Ornish,andLEARNdietsforchangeinweightandrelatedriskfactorsamongoverweightpremenopausalwomen:

theATOZWeightLossStudy:

arandomizedtrial.GardnerCD,KiazandA,AlhassanS,KimS,StaffordRS,BaliseRR,KraemerHC,KingAC.JAMA.2007;297（9）:

969-77

Effectofrawgarlicvscommercialgarlicsupplementsonplasmalipidconcentrationsinadultswithmoderatehypercholesterolemia:

arandomizedclinicaltrial.GardnerCD,LawsonLD,BlockE,ChatterjeeLM,KiazandA,BaliseRR,KraemerHC.ArchInternMed.2007;167（4）:

346-53

Theeffectofaplant-baseddietonplasmalipidsinhypercholesterolemicadults:

arandomizedtrial.GardnerCD,CoulstonA,ChatterjeeL,RigbyA,SpillerG,FarquharJW.AnnInternMed.2005;142（9）:

725-33

Efficacyandsafetyoflow-carbohydratediets:

asystematicreview.BravataDM,SandersL,HuangJ,KrumholzHM,OlkinI,GardnerCD,BravataDM.JAMA.2003;289（14）:

1837-50

Theeffectofsoyproteinwithorwithoutisoflavonesrelativetomilkproteinonplasmalipidsinhypercholesterolemicpostmenopausalwomen.GardnerCD,NewellKA,CherinR,HaskellWL.AmJClinNutr.2001;73（4）:

728-35

EveVanCauter,PhD

TITLE:

SleepLossandobstructivesleepapnea:

LinkswithObesityIRandDiabetes

Appointments:

Professor

DepartmentofMedicine

SectionofEndocrinology,DiabetesandMetabolism

CommitteeonMolecularMedicine/MPMM

CommitteeonMolecularMetabolismandNutrition

Dr.VanCauterisaninternationallyknowninvestigatorincircadianrhythmsonendocrinesysteminnormalandpathologicalconditions.Sheisalsoanexpertinthemathematicalandstatisticalanalysisofthetemporalpatternsofhormonalsecretionandtheeffectsofsleeponendocrinefunction.

Dr.VanCauteristhePrincipalInvestigatorofaProgramProjectwhichisfocusedontheagerelatedchangesincircadianrhythms.Particularlyinterestingfromaphysiologicandtherapeuticstandpointarestudieswhichaimtoinvestigatewhetherreplacementofgrowthhormoneinearlysleeporrestorationofelevatednocturnalmelatoninlevels,twohormonaleventswhicharethoughttoactasinternalsynchronizersinyoungadults,maycorrectcircadianrhythmalterationsinoldersubjects.Dr.VanCauterhasalsodeterminedtheutilityoftheuseofhormonalrhythmsasmarkersofthehumancircadianclockinbasicstudiesexaminingthemechanismsofentrainmentofhormonalrhythms,andtheirimplicationforadaptationtojetlagandshiftwork.Inaddition,Dr.VanCauterisoneoffivepreceptorsintheNorthwesternUniversity-UniversityofChicagoNIHtraininggrantforSleepResearch.

Dr.VanCauterhascollaboratedcloselywithDr.Polonskytodefinetheroleofultradiananddiurnalhormonalrhythmsinglucoseregulation.Inrecentyears,shehasledamajorresearchprogramevaluatingtheimpactofsleeplossonendocrineandmetabolicfunctionandthepossibleendocrinebenefitsofimprovedsleepqualityinolderadults.

Emailaddress:

evcauter@medicine.bsd.uchicago.edu

Universit*LibredeBruxelles,BelgiumMS1970Physics

Universit*LibredeBruxelles,BelgiumMS1972ActuarialSciences

Universit*LibredeBruxelles,BelgiumPhD1977Biophysics

RESEARCHANDPROFESSIONALEXPERIENCE

1970-1981ResearchAssistant,InstituteofInterdisciplinaryResearch,SchoolofMedicine,Universit*LibredeBruxelles,Belgium

1979-1985ResearchAssociate（AssistantProfessor）,Dept.ofMedicine,UniversityofChicago,IL

1982-1987AssociateProfessor（withtenure）,InstituteofInterdisciplinaryResearch,Universit*LibredeBruxelles,Belgium

1987-1990ResearchAssociate（AssociateProfessor）,Dept.ofMedicine,UniversityofChicago,IL

1990-presentResearchAssociate（Professor）,DepartmentofMedicine,UniversityofChicago,Il

HONORSANDAWARDS

1985AwardoftheRobertWalleghemPrizeformedicalresearch

1986Co-recipientoftheHoechstBelgiumPrizeforresearchinbiologicalpsychiatry（withDr.Linkowski）

1989AnnualAwardoftheBelgianEndocrineSociety

1989AwardoftheSoroptimistPrize（50thanniversaryoftheBelgianSoroptimistAssociation）

1994Member,MacArthurFoundationResearchNetworkonMind-BodyInteractions

1994LundbeckPrizeBelgium

1996EditorialBoard,JournalofClinicalEndocrinologyandMetabolism

PUBLICATIONS

（Selectedfromatotalof149）

VanCauterE,RefetoffS.Identificationoftwosub-typesofCushing'sdiseasebasedontheanalysisofepisodiccortisolsecretion.NEnglJMed312:

1343-9,1985.

PolonskyKS,GivenBD,HirschL,ShapiroET,TillilH,BeebeC,FrankBH,GallowayJA,KarrisonT,VanCauterE.Aquantitativestudyofinsulinsecretionandclearanceinnormalandobesesubjects.JClinInvest81:

435-441,1988.

PolonskyKS,GivenBD,VanCauterE.24-hourprofilesandpulsatilepatternsofinsulinsecretioninnormalandobesesubjects.JClinInvest81:

442-448,l988

VanCauterE.Estimatingfalsepositiveandfalsenegativeerrorsinanalysesofhormonalpulsatility.AmJPhysiol254:

E786-94,1988.

PolonskyKS,GivenBD,HirschLJ,TillilH,ShapiroET,BeebeC,FrankBH,GallowayJA,VanCauterE.Abnormalpatternsofinsulinsecretioninnon-insulin-dependentdiabetesmellitus.NewEnglJMed318:

1231-9,1988.

VanCauterE,DesirD,DecosterC,FeryF,BalasseEO.Nocturnaldecreaseofglucosetoleranceduringconstantglucoseinfusion.JClinEndocrinolMetab69:

604-11,1989.

vanCoevordenA,LaurentE,DecosterC,KerkhofsM,NeveP,VanCauterE,MockelJ.Decreasedbasalandstimulatedthyrotropinsecretioninhealthyelderlymen.JClinEndocrinolMetab69:

177-185,1989.

VanCauterE,TurekFW.Strategiesforresettingthehumancircadianclock（editorial）.NewEnglJMed322:

1306-1307,1990.

ShapiroET,PolonskyKS,CopinschiG,BossonD,TillilH,BlackmanJD,LewisG,VanCauterE.NocturnalelevationofglucoselevelsduringfastinginNIDDM.JClinEndocrinolMetab72:

444-454,1991.

SturisJ,VanCauterE,BlackmanJD,PolonskyKS.Entrainmentofpulsatileinsulinsecretionbyoscillatoryglucoseinfusion.JClinInvest87:

439-445,1991.

vanCoevordenA,MockelJ,LaurentE,KerkhofsM,L'Hermite-Bal*riauxM,DecosterC,N*veP,VanCauterE.Neuroendocrinerhythmsandsleepinagingmen.AmJPhysiol260:

E651-E661,1991.

VanCauterE,BlackmanJD,RolandD,SpireJP,RefetoffS,PolonskyKS.Modulationofglucoseregulationandinsulinsecretionbycircadianrhythmicityandsleep.JClinInvest88:

934-942,1991.

SturisJ,PolonskyKS,MosekildeE,VanCauterE.Themechanismsunderlyingultradianoscillationsofinsulinandglucose:

acomputersimulationapproach.AmJPhysiol260:

8