胰岛素抵抗.docx

1、胰岛素抵抗ChristopherGardner Title: Which Diet is Best for Weight Loss in Insulin Resistant Individuals?Director of Nutrition Studies at Stanford Prevention Research Center; Associate Professor of Medicine at Stanford University and CHP/PCOR Associate Hoover Pavilion, Room 403211 Quarry RoadStanford, CA

2、94305cgardnerstanford.eduChristopher D. Gardner, PhD, is the Director of Nutrition Studies at the Stanford Prevention Research Center and an Associate Professor of Medicine at Stanford University. He received his PhD in Nutritional Sciences at the University of California, Berkeley in 1993. His post

3、graduate training included a postdoctoral fellowship in cardiovascular disease epidemiology at Stanford. Dr. Gardner is actively involved in research and teaching. His research focus is on dietary intervention trials designed to test the effects of food components or food patterns on chronic disease

4、 risk factors, including body weight, blood lipids, and inflammatory markers. He has published extensively in peer-reviewed journals, including a recent publication in JAMA presenting his findings from a study contrasting the weight loss effects of four diets ranging from very low to very high carbo

5、hydrate. He speaks nationally within his areas of expertise, which include: Dietary approaches to improve blood lipids, weight loss diets, health benefits of vegetarian and plant-based diets, the optimal diet for cardiovascular health, dietary supplements, and complementary and alternative medicine.

6、Associate Professor (Research), Medicine - Stanford Prevention Research Member, Cancer Center ContactInformationAcademic Offices Personal InformationEmail cgardnerstanford.edu Tel (650) 725-2751 Administrative ContactTraci Hare Administrative Associate Email traci.harestanford.edu Tel Work 721-1057

7、ProfessionalOverviewAdministrative AppointmentsEducation Committee, The Obesity Society (2009 - 2011) Nutrition Committee, American Heart Association (2009 - 2011) Honors and AwardsTeaching Award, Stanford Prevention Research Center (2005) Distinguished Honorary Award, San Jose State University Depa

8、rtment of Nutrition (2003) Regents Fellowship, Univ. Cal. Berkeley (1988) Professional EducationB.A.:Colgate University, Philosophy (1981) PhD:Univ Cal Berkeley, Nutrition Science (1993) Postdoctoral AdviseesFarshad Fani Marvasti , Arianna McClain , Jennifer Otten , Mary Rosenberger , Abu Taiyab Md.

9、 Nazmus Saquib , Veronica Yank Internet LinksSPRC Faculty - C Gardner ScientificFocusCurrent Research InterestsThe role of nutrition and preventive medicine, with particular interests in: plant-based diets and phytochemicals; cardiovascular disease and cancer prevention; weight loss diets; clinical

10、trials and epidemiology. Clinical TrialsEffects of Raw vs. Other Milk Sources on Lactose Digestion Recruiting Adding Sleep Intervention to Traditional Diet and Exercise Approach to Weight Loss Completed Effect of Fish Oil on Plasma Triglycerides in Adults Completed Effects of Dietary Antioxidants on

11、 Cardiovascular Risk Factors Completed Effects of Omega-3 Fatty Acids on Markers of Inflammation Completed PublicationsComparison of the Atkins, Zone, Ornish, and LEARN diets for change in weight and related risk factors among overweight premenopausal women: the A TO Z Weight Loss Study: a randomize

12、d trial. Gardner CD, Kiazand A, Alhassan S, Kim S, Stafford RS, Balise RR, Kraemer HC, King AC. JAMA. 2007; 297 (9): 969-77 Effect of raw garlic vs commercial garlic supplements on plasma lipid concentrations in adults with moderate hypercholesterolemia: a randomized clinical trial. Gardner CD, Laws

13、on LD, Block E, Chatterjee LM, Kiazand A, Balise RR, Kraemer HC. Arch Intern Med. 2007; 167 (4): 346-53 The effect of a plant-based diet on plasma lipids in hypercholesterolemic adults: a randomized trial. Gardner CD, Coulston A, Chatterjee L, Rigby A, Spiller G, Farquhar JW. Ann Intern Med. 2005; 1

14、42 (9): 725-33 Efficacy and safety of low-carbohydrate diets: a systematic review. Bravata DM, Sanders L, Huang J, Krumholz HM, Olkin I, Gardner CD, Bravata DM. JAMA. 2003; 289 (14): 1837-50 The effect of soy protein with or without isoflavones relative to milk protein on plasma lipids in hyperchole

15、sterolemic postmenopausal women. Gardner CD, Newell KA, Cherin R, Haskell WL. Am J Clin Nutr. 2001; 73 (4): 728-35Eve Van Cauter, PhDTITLE: Sleep Loss and obstructive sleep apnea: Links with Obesity IR and Diabetes Appointments:Professor Department of Medicine Section of Endocrinology, Diabetes and

16、Metabolism Committee on Molecular Medicine/MPMMCommittee on Molecular Metabolism and Nutrition Dr. Van Cauter is an internationally known investigator in circadian rhythms on endocrine system in normal and pathological conditions. She is also an expert in the mathematical and statistical analysis of

17、 the temporal patterns of hormonal secretion and the effects of sleep on endocrine function. Dr. Van Cauter is the Principal Investigator of a Program Project which is focused on the age related changes in circadian rhythms. Particularly interesting from a physiologic and therapeutic standpoint are

18、studies which aim to investigate whether replacement of growth hormone in early sleep or restoration of elevated nocturnal melatonin levels, two hormonal events which are thought to act as internal synchronizers in young adults, may correct circadian rhythm alterations in older subjects. Dr. Van Cau

19、ter has also determined the utility of the use of hormonal rhythms as markers of the human circadian clock in basic studies examining the mechanisms of entrainment of hormonal rhythms, and their implication for adaptation to jet lag and shift work. In addition, Dr. Van Cauter is one of five precepto

20、rs in the Northwestern University-University of Chicago NIH training grant for Sleep Research.Dr. Van Cauter has collaborated closely with Dr. Polonsky to define the role of ultradian and diurnal hormonal rhythms in glucose regulation. In recent years, she has led a major research program evaluating

21、 the impact of sleep loss on endocrine and metabolic function and the possible endocrine benefits of improved sleep quality in older adults. Email address: evcautermedicine.bsd.uchicago.eduUniversit* Libre de Bruxelles, Belgium MS 1970 PhysicsUniversit* Libre de Bruxelles, Belgium MS 1972 Actuarial

22、SciencesUniversit* Libre de Bruxelles, Belgium PhD 1977 BiophysicsRESEARCH AND PROFESSIONAL EXPERIENCE1970-1981 Research Assistant, Institute of Interdisciplinary Research, School of Medicine, Universit* Libre de Bruxelles, Belgium1979-1985 Research Associate (Assistant Professor), Dept. of Medicine

23、, University of Chicago, IL1982-1987 Associate Professor (with tenure), Institute of Interdisciplinary Research, Universit* Libre de Bruxelles, Belgium1987-1990 Research Associate (Associate Professor), Dept.of Medicine, University of Chicago, IL1990-present Research Associate (Professor), Departmen

24、t of Medicine, University of Chicago, IlHONORS AND AWARDS1985 Award of the Robert Walleghem Prize for medical research1986 Co-recipient of the Hoechst Belgium Prize for research in biological psychiatry (with Dr. Linkowski)1989 Annual Award of the Belgian Endocrine Society1989 Award of the Soroptimi

25、st Prize (50th anniversary of the Belgian Soroptimist Association)1994 Member, MacArthur Foundation Research Network on Mind-Body Interactions 1994 Lundbeck Prize Belgium 1996 Editorial Board, Journal of Clinical Endocrinology and MetabolismPUBLICATIONS (Selected from a total of 149)Van Cauter E, Re

26、fetoff S. Identification of two sub-types of Cushings disease based on the analysis of episodic cortisol secretion. N Engl J Med 312:1343-9, 1985.Polonsky KS, Given BD, Hirsch L, Shapiro ET, Tillil H, Beebe C, Frank BH, Galloway JA, Karrison T, Van Cauter E. A quantitative study of insulin secretion

27、 and clearance in normal and obese subjects. J Clin Invest 81:435-441, 1988.Polonsky KS, Given BD, Van Cauter E. 24-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects. J Clin Invest 81:442-448, l988Van Cauter E. Estimating false positive and false negative errors

28、in analyses of hormonal pulsatility. Am J Physiol 254:E786-94, 1988.Polonsky KS, Given BD, Hirsch LJ, Tillil H, Shapiro ET, Beebe C, Frank BH, Galloway JA, Van Cauter E. Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus.New Engl J Med 318:1231-9, 1988.Van Cauter E, De

29、sir D, Decoster C, Fery F, Balasse EO. Nocturnal decrease of glucose tolerance during constant glucose infusion. J Clin Endocrinol Metab 69:604-11, 1989.van Coevorden A, Laurent E, Decoster C, Kerkhofs M, Neve P, Van Cauter E, Mockel J. Decreased basal and stimulated thyrotropin secretion in healthy

30、 elderly men. J Clin Endocrinol Metab 69: 177-185, 1989.Van Cauter E, Turek FW. Strategies for resetting the human circadian clock (editorial). New Engl J Med 322: 1306-1307, 1990.Shapiro ET, Polonsky KS, Copinschi G, Bosson D, Tillil H, Blackman JD, Lewis G, Van Cauter E. Nocturnal elevation of glu

31、cose levels during fasting in NIDDM. J Clin Endocrinol Metab 72:444-454, 1991.Sturis J, Van Cauter E, Blackman JD, Polonsky KS. Entrainment of pulsatile insulin secretion by oscillatory glucose infusion. J Clin Invest 87: 439-445, 1991.van Coevorden A, Mockel J, Laurent E, Kerkhofs M, LHermite-Bal*r

32、iaux M, Decoster C, N*ve P, Van Cauter E. Neuroendocrine rhythms and sleep in aging men. Am J Physiol 260: E651-E661, 1991.Van Cauter E, Blackman JD, Roland D, Spire JP, Refetoff S, Polonsky KS. Modulation of glucose regulation and insulin secretion by circadian rhythmicity and sleep. J Clin Invest 88:934-942, 1991.Sturis J, Polonsky KS, Mosekilde E, Van Cauter E. The mechanisms underlying ultradian oscillations of insulin and glucose: a computer simulation approach. Am J Physiol 260: 8