国外英才人物.docx

国外英才人物.docx

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国外英才人物

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RichardBruno

AssociateProfessor,HumanNutrition

RichardBruno'sVitae

325CampbellHallCampbellHall

（614）292-5522

bruno.27@osu.edu

DoctorateofPhilosophyinHumanNutrition,OhioStateUniversity;Columbus,Ohio

MasterofScienceinHumanNutrition,UniversityofDelaware;Newark,Delaware

BachelorofScienceinAppliedNutrition;MinorinBiology,UniversityofDelaware;Newark,Delaware

ResearchInterests

Dr.RichardBrunoisabionutritionistandregistereddietitianwithexpertiseintheareasofphytochemicalandantioxidantutilizationandmetabolisminrelationtofreeradical-mediatedtoxicology.Theresearchconductedinhislaboratoryaimstodefinethemechanismsregulatingthebioavailabilityofphytochemicals,particularlyvitaminEandpolyphenols,andthemechanismsbywhichthesedietaryagentsprotectagainstoxidativestressandpro-inflammatoryresponsesthatotherwisecontributetovascularendothelialdysfunctionandnonalcoholicsteatohepatitis（NASH）.Hisworkroutinelyutilizesobeseexperimentalmodelsandclinicalpopulationshavingheightenedoxidativestressandinflammatoryresponseswiththeunderlyinggoaloftranslatingexperimentalfindingsintopracticalrecommendationsthatpromoteoptimalhealthinhumans.

Atpresent,studiesledbyhislaboratoryaredirectedat:

1Improvingthebioavailabilityofquercetinusingdietarymanipulationsandquercetin-nanoemulsions,

2Definingα-tocopherolbioavailabilityanddietaryrequirementsinindividualswithmetabolicsyndrome,

3Identifyingtheantioxidantandanti-inflammatorymechanismsofgreenteaduringNASH,

4Definingthevasoprotectiveactivitiesofγ-tocopherolsupplementationduringsmokingcessation,and

5Determiningthevasoprotectiveactivitiesofdairyingestioninindividualswithmetabolicsyndrome.

Grants

GreenTeaConfectionsForManagingPostprandialHyperglycemia-InducedVascularEndothelialDysfunction

Sponsor:

TheOhioStateUniversityFoodInnovationCenter（2013-2014）

Thegoalofthisproductistodevelopanovelgreenteacatechincontainingconfectionthataimstoattenuatepostprandialbloodglucoseanditsassociatedeffectsthatinducevascularendothelialdysfunction

Anti-InflammatoryActivitiesOfGreenTeaDuringObesity-InducedNASH

Sponsor:

OhioAgriculturalResearchDevelopmentCenter（2013-2015）

ThegoalofthisprojectistobetterdefinethehepatoprotectivemechanismsbywhichgreenteasuppressesNFκBactivationinadiet-inducedobesemodelofNASH.

DairyFatasaMediatorofVitaminEAdequacyinIndividualswithMetabolicSyndrome

Sponsor:

DairyResearchInitiative（2012-2015）

Thegoalofthisprojectistodefineα-tocopherolbioavailabilityinresponsetodairyfatandevaluatedietaryvitaminErequirementsinindividualswithmetabolicsyndrome.

VasoprotectiveActivitiesofLow-FatMilkinIndividualswithMetabolicSyndrome

Sponsor:

DairyResearchInstitute（2011-2013）

Thegoalofthisprojectistodefinetheacutevasoprotectiveeffectsoflow-fatmilkingestiononpostprandialchangesinvascularendothelialfunctionandnitricoxidehomeostasisinindividualswithmetabolicsyndrome.

CardioprotectiveSynergyofSmokingCessationandγ-TocopherolinRestoringVascularEndothelialFunction

Sponsor:

ConnecticutDepartmentofPublicHealth（2011-2013）

Thegoalofthisprojectistoexaminetheextenttowhichdietaryγ-tocopherolsupplementationimprovesvascularfunctionincombinationwithsmokingcessationbyloweringoxidativestressandpro-inflammatoryresponses

Publications

SWLeonard*,RSBruno*,EPaterson,BCSchock,JAtkinson,TMBray,CECross,MGTraber.（2003）.5-Nitro-gamma-tocopherolincreasesinhumanplasmaexposedtocigarettesmokeinvitroandinvivo.FreeRadicBiolMed,35（12）:

1560-7.*Bothauthorscontributedequally

RSBruno,RRamakrishnan,TJMontine,TMBray,MGTraber.（2005）.alpha-Tocopheroldisappearanceisfasterincigarettesmokersandisinverselyrelatedtotheirascorbicacidstatus.AmJClinNutr;81

（1）:

95-103.

RSBrunoandMGTraber.（2005）.CigarettesmokealtershumanvitaminErequirements.JNutr;135（4）:

671-4（InvitedReview）.

RSBruno,SWLeonard,JLi,TMBray,MGTraber.（2005）.Lowerplasmaalpha-carboxyethyl-hydroxychromanafterdeuteriumlabeledalpha-tocopherolsupplementationsuggestsdecreasedvitaminEmetabolisminsmokers.AmJClinNutr;81（5）:

1052-9.（¥PublicationnamedbytheNIHtotheTop25DietarySupplementationstudiesfor2005）.

RSBruno¥,SWLeonard,RRamakrishnan,JAtkinson,TJMontine,TMBray,MGTraber.（2006）.FasterplasmavitaminEdisappearanceinsmokersisnormalizedbyvitaminCsupplementation.FreeRadicBiolMed;40（4）:

689-97;EpubNov152005.（¥Receivedcommentary:

BuettnerGR.（2006）.Commentaryon"FasterplasmavitaminEdisappearanceinsmokersisnormalizedbyvitaminCsupplementation".FreeRadicBiolMed;40（4）:

555-6）.

RSBruno,SWLeonard,S-IPark,YZhao,MGTraber.（2006）.HumanvitaminErequirementsassessedwiththeuseofapplesfortifiedwithdeuterium-labeledα-tocopherylacetate.AmJClinNutr;83:

299-304.

RSBrunoandMGTraber.（2006）.VitaminEbiokinetics,oxidativestressandcigarettesmoking.Pathophysiology;13（3）:

143-9.（InvitedReview）.

RSBruno,YSong,SWLeonard,DJMustacich,AWTaylor,MGTraber,EHo.（2007）.DietaryzincrestrictioninratsaltersantioxidantstatusandincreasesplasmaF2-Isoprostanes.JNutrBiochem;18（8）:

509-18.

RSBruno¥,CEDugan,JASmyth,DADiNatale,SIKoo.（2008）.Greenteaextractprotectsleptin-deficient,spontaneouslyobesemicefromhepaticsteatosisandinjury.JNutr,138

（2）:

323-31.（¥Receivedcommentary:

AmericanSocietyforNutrition（2008）.Aninternationalpressreleasewasissuedthathighlightedthefindingsofthisinvestigation.

AWTaylor,RSBruno,MGTraber.（2008）.WomenandsmokershaveelevatedurinaryF2-isoprostanemetabolites;determinationsusinganovelextractionandLC-MSmethodology.Lipids;43（10）:

925-36.

DJMustachich,KGohil,RSBruno,MYan,SWLeonard,EHo,CECross,MGTraber.（2008）.Alpha-tocopherolmodulatesgenesinvolvedinhepaticxenobioticpathwaysinmice.JNutrBiochem;20（6）:

469-76.

AMKenny,KMMangano,RHAbourizk,RSBruno,DEAnamani,AKleppinger,SJWalsh,KMPrestwood,JEKerstetter.（2009）.Soyproteinsandisoflavonesaffectbonemineraldensityinolderwomen:

arandomizedcontrolledtrial.AmJClinNutr;90

（1）:

234-42.

UTIwaniec¥,RTTurner,SIKoo,RKaur,EHo,CPWong,RSBruno.（2009）.Consumptionofgreenteaextractresultsinosteopeniaingrowingmice.JNutr;139（10）:

1914-9.（¥Receivedcommentary:

AmericanSocietyforNutrition（2009）.Aninternationalpressreleasewasissuedthathighlightedthefindingsofthisinvestigation）.

M-YChung,SFYeung,HJPark,JSVolek,RSBruno.（2010）.Dietaryα-andγ-tocopherolprotectagainstLPS-triggeredhepaticinjuryinspontaneouslyobesemice.JNutrBiochem,21（12）:

1200-6.

HJPark,SRDavis,H-YLiang,DWRosenberg,RSBruno.（2010）.Chlorogenicaciddifferentiallyaltershepaticandsmallintestinalthiolredoxstatuswithoutprotectingagainstazoxymethane-inducedcoloncarcinogenesisinmice.NutrCancer,62（3）:

362-370.

HJPark,DDDiNatale,M-YChung,J-YLee,SIKoo,RSBruno.（2011）.Greenteaextractattenuateshepaticsteatosisbydecreasingadiposelipogenesisandenhancinghepaticantioxidantdefensesinob/obmice.JNutrBiochem,22（4）:

393-400.

HJPark,EMah,RSBruno.（2010）.ValidationofHPLC-borondopeddiamonddetectionforassessinghepaticglutathioneredoxstatus.AnalBiochem,407

（2）:

151-9.

AHsu,RSBruno,CVLoehr,RHDashwood,TMBray,andEHo.（2011）.SoyandteainhibitchronicinflammationandNFkappaBactivationinhormone-inducedprostatecarcinogenesisinNoblerats.JNutrBiochem,22（5）:

502-10.

EMah,MDMatos,DMKawiecki,KDBallard,YGuo,JSVolek,RSBruno.（2011）.VitaminCstatusisrelatedwithpro-inflammatoryresponsesandvascularendothelialfunctioninhealthycollege-agedleanandobesemen.JAmDietAssoc,111（5）:

737-43.

CPWong,LPNguyen,SKNoh,TMBray,RSBruno,EHo.（2011）.InductionofregulatoryTcellsbygreenteapolyphenolEGCG.ImmunolLett,139（1-2）:

7-13.

EMah,SKNoh,KDBallard,MEMatos,JSVolek,RSBruno.（2011）.Postprandialhyperglycemiaimpairsvascularendothelialfunctioninhealthymenbyinducinglipidperoxidationandincreasingasymmetricdimethylarginine/arginine.JNutr,141（11）:

1961-8.（¥Receivedcommentary:

AmericanSocietyforNutrition（2011）.Aninternationalpressreleasewasissuedthathighlightedthefindingsofthisinvestigation）.

MYChung,HJPark,MO’Conner,JManautou,RSBruno.（2012）.Greenteaextractprotectsagainstnonalcoholicsteatohepatitisinob/obmicebydecreasingoxidativeandnitrativestressresponsesinducedbypro-inflammatoryenzymes.JNutrBiochem,23（4）:

361-7

CMasterjohn,EMah,YGuo,SIKoo,RSBruno（2012）.γ-Tocopherolabolishespostprandialincreasesinplasmamethyglyoxalfollowinganoraldoseofglucoseinhealthy,college-agedmen.JNutrBiochem,23（3）:

292-8.

HJPark,J-YLee,M-YChung,Y-KPark,AMBower,SIKoo,CGiardina,RSBruno.（2012）.GreenteaextractsuppressesNFκBactivationandinflammatoryresponsesindiet-inducedobeseratswithnonalcoholicsteatohepatitis.JNutr,142

（1）:

57-63.

CMasterjohnandRSBruno.（2012）.Therapeuticpotentialofgreenteaonnonalcoholicfattyliverdisease.NutrRev,70

（1）:

41-56.（InvitedReview）.

EMahandRSBruno.（2012）.Postprandialhyperglycemiaonvascularendothelialfunction:

mechanismsandconsequences.NutrRes,32（10）:

727-40.

EMah,SKNoh,KDBallard,HJPark,JSVolek,RSBruno.（2013）.Supplementationofaγ-tocopherol-richmixtureoftocopherolsinhealthymenprotectsagainstvascularend