药理学英文试题含复习资料.docx

药理学英文试题含复习资料.docx

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药理学英文试题含复习资料

1山东大学医学院（2005——2006学年第二学期）

2003级医学七年制药理学期末考试试题（A卷）

二、选择题：

（A型每题0.5分，X型每题1分,共50分）

TypeAchoicequestions（onlyoneansweriscorrect）

1.WhichofthefollowingisclassifiedasbelongtotheGprotein

couplingreceptors?

A.GABAAreceptor

B.badrenergic

receptor

C.insulinreceptor

D.nicotinicIIreceptor

E.hydrocortisonereceptor

2.Whichofthefollowingisunlikelytobeassociatedwithoraldrugadministrationofan

entericcoated

dosageform?

A.irritationtothegastricmucosawithnauseaandvomiting

B.destructionofthedrugbygastricacidordigestiveenzymes

C.unpleasanttasteofthedrug

D.formationofnonabsorbabledrugfood

complexes

E.variabilityinabsorptioncausedbyfluctuationsingastricemptyingtime

3.Whichofthefollowingcompoundswillbeabsorbedtotheleastextentinthestomach?

A.ampicillin（pKa=2.5）

B.aspirin（pKa=3.0）

C.warfarin（pKa=5.0）

D.Phenobarbital（pKa=7.4）

E.propranolol（pKa=9.4）

4.Whichofthefollowingtermsismostlikelytobeassociatedwith“arapidreductioninthe

effectofagivendoseofadrugafteronlyoneortwodoses”?

A.supersensitivity

B.tachyphylaxis

C.tolerance

D.hyposensitivity

E.anaphylaxis

5.Aweakacidicdrugwith4.4ofpKa,ifthestomachjuicepHis1.4,plasmapHis7.4,when

thedistributionbalanceisreached,thedrugconcentrationratiobetweenplasmaandstomach

juiceis

A.100

B.0.001

C.1000

D.10000

E.0.01

6.Inthisgraph，drugsA，BandCareanalogs，then

A.AhasagreaterpotencythanB

B.AhasagreaterefficacythanC

C.BhaslesspotencythanC

D.AhasagreaterpotencythanC

E.BhasagreaterefficacythanC

7.Aspirinisaweakacidwith3.5ofpKa,whatpercentageoflipidsoluble

formwillbeinthe

stomachjuicewith2.5ofpH?

A.0.99%

B.9%

C.9.09%

D.90.9%

E.99.9%

8.Thecontractileeffectofvariousdosesofnorepinephrine（NE）（X）aloneonvascularsmooth

muscleisrepresentedinthefigurebelow.Whencombinedwithanantagonist（ICorINC）,a

shiftinthedoseresponse

curveoccurs.ThecurvelabeledX+INCwouldmostlylikelyoccur

whenvascularsmoothmuscleistreatedwithNEinthepresen

A.terazosin

B.phentolamine

C.labetalol

D.phenoxybenzamine

E.prazosin

B

A

C

效应

Log剂量

4

9.ThereversiblecholinesteraseinhibitorindicatedinthetreatmentofAlzheimer’sdiseaseis

A.tacrine

B.edrophonium

C.neostigmine

D.pyridostigmine

E.ambenonium

10.Apredictablydangeroussideeffectofnadololthatconstitutesacontraindicationtoits

clinicaluseinsusceptiblepatientsistheinductionof

A.hypertension

B.cardiacarrhythmia

C.asthmaticattacks

D.respiratorydepression

E.hypersensitivity

11.Epinephrinemaybemixedwithcertainanesthetics,suchasprocaine,inorderto

A.stimulatelocalwoundrepair

B.promotehemostasis

C.enhancetheirinteractionwithneuralmembranesandtheirabilitytodepressnerve

conduction

D.retardtheirsystemicabsorption

E.facilitatetheirdistributionalongnerves

12.A58yearold

malewithanginaistreatedwithatenolol.Selectthemechanismofactionof

atenolol

A.aadrenergic

agonist

B.aadrenergic

antagonist

C.badrenergic

agonist

D.badrenergic

antagonist

E.mixedaandbantagonist

13.Amalepatientisbroughttotheemergencydepartmentfollowingingestionofanunknown

substance.Heisfoundtohaveanelevatedtemperature,hotandflushedskin,dilatedpupils,

andtachycardia.Ofthefollowing,whichwouldmostlikelycausethesefindings?

5

A.propranolol

B.tolazoline

C.prazosin

D.donepezil

E.atropine

14.A65yearold

malehasabloodpressureof170/105mmHg.Whichofthefollowingwould

beeffectiveinloweringthispatient’sbloodpressure?

A.terbutaline

B.dobutamine

C.pancuronium

D.prazosin

E.scopolamine

15.Whichofthefollowingcanbeusedinshockforincreasingcardiacoutputandrenalblood

flow?

A.norepinephrine

B.epinephrine

C.dopamine

D.phenylephrine

E.methoxamine

16.AllofthefollowingstatementsarerelatedwithsuccinylcholineEXCEPT

A.havemusclefasciculationbeforemusclerelaxation

B.havenoganglionicblockingactionsattherapeuticdose

C.canbeantagonizedbyneostigmine

D.elevatebloodpotassiumconcentration

E.assistantagentsofanesthetics

17.Theagentwhichiseffectiveforprostatichyperplasiabuthasnoeffectonbloodpressureis

A.terazosin

B.tamsulosin

C.phenoxybenzamine

D.regitine

E.prazosin

18.Whichofthefollowingstatementsiscorrect?

A.Diazepaminducethedrugmetabolizingenzymes.

B.Allbenzodiazepinesshowantiepilepticactions.

C.Allbenzodiazepineshavesedativeeffects.

D.Benzodiazepinesreadilyproducegeneralanesthesia.

E.Benzodiazepinesdirectlyopenchloridechannels.

19.Whichofthefollowingstatementsiscorrect?

A.Chlorpromazineisindicatedintreatingthenauseaoflevodopatreatment.

B.VitaminB6increasestheeffectivenessoflevodopa.

6

C.AdministrationofdopamineisaneffectivetreatmentofParkinson’sdisease.

D.Levodopainduced

nauseaisreducedbycarbidopa.

E.NonspecificMAOinhibitors

areausefuladjuncttolevodopatherapy.

20.WhichofthefollowingiscommontothetricyclicantidepressantsandMAOinhibitors?

A.Theycanproducesedation.

B.Theyproducephysicaldependence.

C.Theyshowstronginteractionwithcertainfoods.

D.Theycanproduceposturalhypotension.

E.Theydecreaseavailabilityofepinephrineinthesynapticcleft

21.Theantipsychoticdrugs:

A.areequallyeffectiveagainstthepositiveandnegativesymptomsofschizophrenia

B.cancauseblurredvision,urinaryretentionandothersignsofmuscarinicblockade

C.bindselectivelytoD2dopaminergic

receptors.

D.haveantiparkinsonismeffectssimilartolevodopa.

E.havearapidonsetofantipsychoticaction.

22.AllofthefollowingareobservedinpatientstakingneurolepticagentsEXCEPT:

A.sexualdysfunction.

B.bronchialasthma

C.alteredendocrinefunction.

D.constipation.

E.orthostatichypotension

23.WhichofthefollowingstatementsaboutmorphineisINCORRECT?

A.Itisusedtherapeuticallytorelievepaincausedbysevereheadinjury.

B.Itswithdrawalsymptomscanberelievedbymethadone.

C.Itcausesconstipation.

D.Itismosteffectivebyparenteraladministration.

E.Itrapidlyentersmanybodytissues,includingthefetusofapregnantwoman.

24.WhichofthefollowingstatementsconcerningphenytoinisINCORRECT?

A.causeslesssedationthanphenobarbital.

B.causesgingivalhyperplasia.

C.maycausemegaloblasticanemia

D.isexcretedunchangedintheurine.

E.Theplasmahalflife

increasesasthedoseisincreased.

25.Whichofthefollowingdrugsiscontraindicatedinthepatientswithepilepsy?

A.Phenobarbital

B.imipramine

C.digoxin

D.chlorpromazine

E.aspirin

26.Theagentwhichiseffectiveforvariousepilepsyis

7

A.diazepam

B.sodiumphenytoin

C.sodiumvalproate

D.Phenobarbital

E.ethosuximide

27.AllofthefollowingproduceasignificantdecreaseinperipheralresistanceEXCEPT:

A.chronicadministrationofdiuretics

B.hydralazine

C.ACEinhibitors

D.βR

blockers

E.calciumchannelblockers

28.Whichofthefollowinghypertensivepatientsismostsuitbleforprimarytherapywith

hydrochlorothiazide?

A.patientswithgout

B.patientswithhyperlipidemia

C.younghypertensivepatientswithrapidrestingheartrate

D.patientswithimpairedrenalfunction

E.elderlypatients

29.Regardingantihypertensivedrugs,whichofthefollowingstatementsisWRONG？

A.Hydrochlorothiazidecanincreaseactivityofrennin

B.Propranololcandecreasesecretionofrennin

C.SodiumnitroprussidelowersBPrapidlybyreleasingNO.

D.Clonidinestimulatesα2receptor

andimidazolinereceptor

E.DiureticsdecreasedBPmainlybyincreasingwaterandsodiumexcretionfromthe

kidneys.

30.Whichofthefollowingdrugsoccursorthostatichypotensionmostfrequentlyinfirstuse:

A.clonidine

B.nifedipine

C.propranolol

D.enalapril

E.prazosin

31.Thereasonthatdigoxincanreducetheventricularrateofatrialfibrillationpatientis:

A.decreasingautomaticityofventricles

B.decreasingautomaticityofatria

C.reducingtheconductionofAV

node

D.improvingcardiacischemia

E.shorteningtheeffectiverefractoryperiodofatria

32.Allofthefollowingmeasurescanbeusedinthetreatmentofdigoxininduced

arrhythmia

EXCEPT

A.stoppingdigoxinadministration

8

B.diureticagentssuchasfurosemideareusedtopromotetheexcretionofdigoxin

C.phenytoinadministration

D.atropineadministration

E.lidocaineadministration

33.WhichofthefollowingeffectsofdigoxincanNOTbeseeninfailureheart?

A.slowingsinusrhythm

B.increasingtheoxygenconsumptionofmyocardia

C.increasingthecardiacoutput

D.increasingthecardiaccontractility

E.shorteningatrialERP

34.A70yearold

femaleistreatedwithsublingualnitroglycerinforheroccasionalboutsof

angina.Whichofthefollowingisinvolvedintheactionofnitroglycerin?

A.αadrenergic

activity

B.phosphodiesteraseactivity

C.phosphorylationoflightchainsofmyosin

D.norepinephrinerelease

E.cGMPincreased

35.Thetherapeuticeffectofβadrenergic

receptorblockerssuchaspropranololinangina

pectorisisbelievedtobeprimarilytheresultof

A.reducedproductionofcatecholamines

B.dilationofthecoronaryvasculature

C.decreasedrequirementformyocardialoxygen

D.increasedperipheralresistance

E.increasedsensitivitytocatecholamines

36.A69yearold

malewithanginadevelopssevereconstipationfollowingtreatmentwith

A.nitroglycerin

B.gemfibrozil（吉非贝齐）

C.propranolol

D.captopril

E.verapamil

37.Whichofthefollowingdrugshasrelativelyfewelectrophysiologi