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snoimmunesystemtostopthemreplicating.Youcanregarditasthecancer'
sAchilles'
heel."
6.Onlyasmallamountofthevirusneedstogettothecancer."
Theyreplicate,yougetamillioncopiesineachcellandthecellburstsandtheyinfectthetumourcellsadjacentandrepeattheprocess,"
saidProfSeymour.
7.Preliminaryresearchonmiceshowsthatthevirusesworkwellontumoursresistanttostandardcancerdrugs."
It'
saninterestingpossibilitythattheymayhaveanadvantageinkillingdrug-resistanttumours,whichcouldbequitedifferenttoanythingwe'
vehadbefore."
8.Researchershaveknownforsometimethatvirusescankilltumourcellsandsomeaspectsoftheworkhavealreadybeenpublishedinscientificjournals.Americanscientistshavepreviouslyinjectedvirusesdirectlyintotumoursbutthistechniquewillnotworkifthecancerisinaccessibleorhasspreadthroughoutthebody.
9.ProfSeymour'
sinnovativesolutionistomaskthevirusfromthebody'
simmunesystem,effectivelyallowingthevirusestodowhatchemotherapydrugsdo-spreadthroughthebloodandreachtumourswherevertheyare.Thebighurdlehasalwaysbeentofindawaytodelivervirusestotumoursviathebloodstreamwithoutthebody'
simmunesystemdestroyingthemontheway.
10."
Whatwe'
vedoneismakechemicalmodificationstothevirustoputapolymercoataroundit-it'
sastealthviruswhenyouinjectit,"
11.Afterthestealthvirusinfectsthetumour,itreplicates,butthecopiesdonothavethechemicalmodifications.Iftheyescapefromthetumour,thecopieswillbequicklyrecognisedandmoppedupbythebody'
simmunesystem.
12.Thetherapywouldbeespeciallyusefulforsecondarycancers,calledmetastases,whichsometimesspreadaroundthebodyafterthefirsttumourappears."
There'
sanawfulstatisticofpatientsinthewest...withmalignantcancers;
75%ofthemgoontodiefrommetastases,"
13.Twovirusesarelikelytobeexaminedinthefirstclinicaltrials:
adenovirus,whichnormallycausesacold-likeillness,andvaccinia,whichcausescowpoxandisalsousedinthevaccineagainstsmallpox.Forsafetyreasons,bothwillbedisabledtomakethemlesspathogenicinthetrial,butProfSeymoursaidheeventuallyhopestousenaturalviruses.
14.Thefirsttrialswilluseuncoatedadenovirusandvacciniaandwillbedeliveredlocallytolivertumours,inordertoestablishwhetherthetreatmentissafeinhumansandwhatdoseofviruswillbeneeded.Severalmoreyearsoftrialswillbeneeded,eventuallyalsoonthepolymer-coatedviruses,beforethetherapycanbeconsideredforuseintheNHS.Thoughtheapproachwillbeexaminedatfirstforcancersthatdonotrespondtoconventionaltreatments,ProfSeymourhopesthatonedayitmightbeappliedtoallcancers.
Questions1-6
Dothefollowingstatementsagreewiththeinformationgiveninthereadingpassage?
Forquestions1-6write
TRUE
ifthestatementagreeswiththeinformation
FALSE
ifthestatementcontradictstheinformation
NOTGIVEN
ifthereisnoinformationonthisinthepassage
1.Virustherapy,ifsuccessful,hasanadvantageineliminatingside-effects.
2.CancerResearchUKisquitehopefulaboutProfessorSeymour’sworkonthevirustherapy.
3.Viruscankillcancercellsandstopthemfromgrowingagain.
4.Cancer’sAchilles’heelreferstothefactthatvirusmaystaysafelyinatumorandreplicate.
5.Toinfectthecancercells,agooddealofvirusesshouldbeinjectedintothetumor.
6.Researchesonanimalsindicatethatviruscouldbeusedasanewwaytotreatdrug-resistanttumors.
Question7-9
Basedonthereadingpassage,choosetheappropriateletterfromA-Dforeachanswer.
7.Informationaboutresearchesonviruseskillingtumorcellscanbefound
(A)
onTV
(B)
inmagazines
(C)
oninternet
(D)
innewspapers
8.Totreattumorsspreadingoutinbody,researcherstryto
changethebody’immunesystem
injectchemotherapydrugsintobloodstream.
increasetheamountofinjection
disguisethevirusesonthewaytotumors.
9.Whenthechemicalmodifiedvirusintumorreplicates,thecopies
willsoonescapefromthetumorandspreadout.
willbewipedoutbythebody’simmunesystem.
willbeimmediatelyrecognizedbytheresearchers.
willeventuallystopthetumorfromspreadingout.
Questions10-13
Completethesentencesbelow.Chooseyouranswersfromthelistofwords.Youcanonlyuseeachwordonce.
NB
Therearemorewordsinthelistthanspacessoyouwillnotusethemall.
Inthefirstclinicaltrials,scientistswilltryto……10……adenovirusandvaccinia,soboththeviruseswillbelesspathogenicthanthe……11…….Theseuncoatedviruseswillbeapplieddirectlytocertainareastoconfirmsafetyonhumanbeingsandtheright……12……needed.Theexperimentswillfirstlybe……13……tothetreatmentofcertaincancers
ListofWords
dosage
responding
smallpoxvirus
disable
naturalones
inject
directed
treatment
cold-likeillness
kill
patients
examined
AnswersKeys:
1.答案:
FALSE(见第2段:
Ifsuccessful,virustherapycouldeventuallyformathirdpillaralongsideradiotherapyandchemotherapyinthestandardarsenalagainstcancer,whileavoidingsomeofthedebilitatingside-effects.Virustherapy只能避免一些副作用,而不是根除。
)
2.答案:
TRUE(见第3段,特别是最后一句:
CancerResearchUKsaidyesterdaythatitwasexcitedbythepotentialofProfSeymour'
spioneeringtechniques.)
3.答案:
NOTGIVEN(文中没有提到virus可以抑制肿瘤细胞再生长)
4.答案:
TRUE(见第5段第3、4句:
这里“cancer’sAchilles'
heel”指“Ifyoucangetavirusintoatumour,virusesfindthemaverygoodplacetobebecausethere'
snoimmunesystemtostopthemreplicating.”Achilles'
heel的意思是“唯一致命弱点”)
5.答案:
FALSE(见第6段第第1句:
Onlyasmallamountofthevirusneedstogettothecancer.)
6.答案:
TRUE(见第7段:
Preliminaryresearchonmiceshowsthatthevirusesworkwellontumoursresistanttostandardcancerdrug.……,whichcouldbequitedifferenttoanythingwe'
)
7.答案:
B(见第8段第1、2句:
Researchershaveknownforsometimethatvirusescankilltumourcellsandsomeaspectsoftheworkhavealreadybeenpublishedinscientificjournals.Journal意思是“日报、期刊、杂志”)
8.答案:
D(见第9段第1句:
ProfSeymour'
simmunesystem,……“mask”的意思是“掩盖、隐蔽、伪装”,在这里和“disguise”同义。
)
9.答案:
B(见第11段第2句:
Iftheyescapefromthetumour,thecopieswillbequicklyrecognisedandmoppedupbythebody'
simmunesystem..“mopup”这里与“wipeout”同义,意思是“消灭、歼灭”。
10.答案:
disable(见第13段最后1句:
Forsafetyreasons,bothwillbedisabledtomakethemlesspathogenicinthetrial,butProfSeymoursaidheeventuallyhopestousenaturalviruses.)
11.答案:
naturalones(见第13段最后1句:
12.答案:
dosage(见第14段第1句:
Thefirsttrialswilluseuncoatedadenovirusandvacciniaandwillbedeliveredlocallytolivertumours,inordertoestablishwhetherthetreatmentissafeinhumansandwhatdoseofviruswillbeneeded.)
13.答案:
directed(见第14段最后1句:
Thoughtheapproachwillbeexaminedatfirstforcancersthatdonotrespondtoconventionaltreatments,…)
2
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