当今干细胞研究方面的10位顶尖科学家.docx

1、当今干细胞研究方面的10位顶尖科学家排名第一：Shinya Yamanaka和JamesA.Thomson博士是建立了可诱导的万能干细胞，在干细胞再生和分化重排机理上做出了最具突破性的进展性工作；这毫无疑问是诺贝尔奖级的工作，其他几位平时工作很杰出，可是没有这种级别的工作，只好屈居次位；排名第二：Rudolf Jaenisch博士长期从事于干细胞核的替代重组和干细胞的表观遗传修饰工作，卓有成绩，这也是培养诱导干细胞的核心工作，重要性无人能代替；排名第三： Rebort lanza博士领导和指挥着全球最领先的干细胞生物技术公司，独创和建立了分离和培养单个胚胎干细胞的方法和技术。主编了所有重要的干

2、细胞参考书籍。每一相重大干细胞技术的出现，美欧主流媒体都要听他的意见，可谓干细胞领域的大腕人物；排名第四：Alan Trounson博士是国际免疫学和干细胞研究的先驱者，领导和指挥原澳大利亚Monash大学免疫学和干细胞研究实验室，使Monash大学成为世界上最成功的大学之一。手下的弟子Martin Perl博士出任南加州大学第一界干细胞和系统生物学所所长。2007年成为美国眼下资金最多，实力最强的加州再生医学研究研究所所长，成为美国干细胞研究中最大的老板；排名第五：哈佛大学干细胞研究所所长Douglas A. Melton博士和斯坦福大学干细胞和再生医学研究所所长Irving L. Weis

3、sman博士两人都是干细胞研究领域的顶尖高手，又各了带领着东西两岸这两所美国奈至全世界的顶尖学府的干细胞研究的竟赛。排名第六：哈佛大学干细胞研究所共同所长David T. Scadden, 博士和密西根大学干细胞中心主Sean Morrison博士两人是干细胞研究的中青年骨干，专长于干细胞分化再生的微环境调控机理的研究，. Scadden, 博士是麻省总医院再生医学研究所所长，侧重于干细胞的临床应用。Morrison博士则是休斯医学研究所研究员，是美国中西部大学中干细胞研究的顶级人物。排名第七到第十的是国际上知名的干细胞专家，包括爱丁堡大学克隆了多利羊的Wilmut教授，皮肤毛发干细胞再生医学

4、领军人物Fuchs教授和把干细胞用于临床治疗的先锋人物瑞典的Lindvall教授，以及华人中干细胞研究的顶尖人物，由中国人出任的耶鲁大学干细胞中心主任林海帆教授。第一位：Shinya Yamanaka，Ph.D. 日本京都大学前沿医学研究所干细胞生物学系，加州大学旧金山分校心血管疾病研究所教授代表作文章1. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S.Induction of pluripotent stem cells from adult human fibroblasts by d

5、efined factors. Cell. 2007 Nov 30;131(5):861-72. 2. Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells.Nature. 2007 Jul 19;448(7151):313-7. 3. Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S.

6、 Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts.Nat Biotechnol. 2007 Nov 30;4. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25;126(4):663-76. Epub 2006 Aug

7、 10。5. Takahashi K, Ichisaka T, Yamanaka S. Identification of genes involved in tumor-like properties of embryonic stem cells. Methods Mol Biol. 2006;329:449-58. 并列第一位：JamesA.Thomson Ph.D.威斯康星大学基因组研究中心主任，解剖学系教授代表作文章1.Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jo

8、nsdottir GA, Ruotti V, Stewart R, Slukvin II, Thomson JA.Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells。Science. 2007 Nov 202.Ludwig TE, Bergendahl V, Levenstein ME, Yu J, Probasco MD, Thomson JA.Feeder-independent culture of human embryonic stem cells.Nat Methods. 2006 Aug;3(8

9、):637-463.Ludwig TE, Levenstein ME, Jones JM, Berggren WT, Mitchen ER, Frane JL, Crandall LJ, Daigh CA, Conard KR, Piekarczyk MS, Llanas RA, Thomson JA.Derivation of human embryonic stem cells in defined conditions.Nat Biotechnol. 2006 Feb;24(2):185-7.4. Yu J, Vodyanik MA, He P, Slukvin II, Thomson

10、JA.Human embryonic stem cells reprogram myeloid precursors following cell-cell fusion.Stem Cells. 2006 Jan;24(1):168-76. Epub 2005 Oct 65. Sperger JM, Chen X, Draper JS, Antosiewicz JE, Chon CH, Jones SB, Brooks JD, Andrews PW, Brown PO , Thomson JA.Gene expression patterns in human embryonic stem c

11、ells and human pluripotent germ cell tumors.Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13350-5.第二位：Rudolf Jaenisch MD，麻省理工学院白头生物研究所教授代表作文章1. Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R.Treatment of Sickle Cell Anemia Mouse Mo

12、del with iPS Cells Generated from Autologous Skin.Science. 2007 Dec 6；2. Meissner A, Wernig M, Jaenisch R.Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells.Nat Biotechnol. 2007 Oct;25(10):1177-81；3. Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger

13、 K, Bernstein BE, Jaenisch R.In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state.Nature. 2007 Jul 19;448(7151):318-24；4. Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA,

14、 Jaenisch R.Polycomb complexes repress developmental regulators in murine embryonic stem cells.Nature. 2006 May 18;441(7091):349-53；5. Meissner A, Jaenisch R.Generation of nuclear transfer-derived pluripotent ES cells from cloned Cdx2-deficient blastocysts.Nature. 2006 Jan 12;439(7073):212-5。第三位： Re

15、bort lanza Ph.D. 麻省先进细胞公司首席科学家，北卡州Wake Forest 大学医学院教授1. Klimanskaya I, Chung Y, Becker S, Lu SJ, Lanza R.Human embryonic stem cell lines derived from single blastomeres.Nature. 2006 Nov 23;444(7118):481-5. 2. Lu SJ, Feng Q, Caballero S, Chen Y, Moore MA, Grant MB, Lanza R.Generation of functional he

16、mangioblasts from human embryonic stem cells.Nat Methods. 2007 Jun;4(6):501-93. Chung Y, Klimanskaya I, Becker S, Marh J, Lu SJ, Johnson J, Meisner L, Lanza R.Embryonic and extraembryonic stem cell lines derived from single mouse blastomeres.Nature. 2006 Jan 12;439(7073):216-9.4. Lanza RP, Chung HY,

17、 Yoo JJ, Wettstein PJ, Blackwell C, Borson N, Hofmeister E, Schuch G, Soker S, Moraes CT, West MD, Atala A. Generation of histocompatible tissues using nuclear transplantation. Nat Biotechnol. 2002 Jul;20(7):689-96.5. Lanza RP, Cibelli JB, Blackwell C, Cristofalo VJ, Francis MK, Baerlocher GM, Mak J

18、, Schertzer M, Chavez EA, Sawyer N, Lansdorp PM, West MD. Extension of cell life-span and telomere length in animals cloned from senescent somatic cells. Science. 2000 Apr28;288(5466):665-9第四位：Alan Trounson Ph.D. 加州再生医学研究研究所所长，教授（原澳大利亚Monash大学免疫学和干细胞研究实验室主任）代表作文章1. GQ Daley, L AhrlundRichter,JM Auer

19、bach, N Benvenisty, RA Charo, G Chen, HK Deng,LS Goldstein, KL Hudson, I Hyun, SC Junn, J Love, EH Lee, A McLaren, CL Mummery,N Nakatsuji, C Racowsky, H Rooke, J Rossant, HR Scholer, JH Solbakk, P Taylor, AOTrounson, IL Weissman, I Wilmut, J Yu, L Zoloth (2007) The ISSCR Guidelines for Human Embryon

20、ic Stem Cell Research. Science 315: 603604. 303. 2. A Giudice and A Trounson (2007) Genetic manipulation of human embryonic stem cells for cell based therapy. Nature Biotech；3. M Snow, SL Cox, G Jenkin, A Trounson, J Shaw (2002) Generation of live young from xenografted mouse ovaries. Science 297: 2

21、227.4. BE Reubinoff, MF Pera, CY Fong, A Trounson, A Bongso (2000) Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nature Biotechn. 18: 399404.5. AT Dowsing, EL Yong, M Clark, RI McLachlan, DM de Kretser, AO Trounson (1999) Linkage between male infertility and tri

22、nucleotide repeat expansion in the androgen receptor gene. Lancet 354: 640643.第五位：Douglas A. Melton, Ph.D，哈佛大学干细胞研究所所长，Howard Hughes Medical Institute研究员。代表作文章1. Stanger BZ, Tanaka AJ, Melton DA.Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver.Natur

23、e. 2007 Feb 22;445(7130):886-91.2. Cowan CA, Atienza J, Melton DA, Eggan K.Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells.Science. 2005 Aug 26;309(5739):1369-73. 3. Dor Y, Brown J, Martinez OI, Melton DA.Adult pancreatic beta-cells are formed by self-duplication

24、rather than stem-cell differentiation.Nature. 2004 May 6;429(6987):41-6. 4. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA.Insulin staining of ES cell progeny from insulin uptake.Science. 2003 Jan 17;299(5605):363.5. Ramalho-Santos M, Yoon S, Matsuzaki Y, Mulligan RC, Melton DA.Stemness: t

25、ranscriptional profiling of embryonic and adult stem cells.Science. 2002 Oct 18;298(5593):597-600.并列第5位Irving L. Weissman MD. 斯坦福大学干细胞和再生医学研究所所长代表作文章1.Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL Deficiencies in DNA damage repair limit the function of haematopoietic stem ce

26、lls with age. Nature 2007; 447: 7145: 725-92. Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegu E.New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors.Cell. 2006 Jul 28;126(2):415-263. Laird DJ, De Tomaso AW, Weissman IL.Stem cells are u

27、nits of natural selection in a colonial ascidian.Cell. 2005 Dec 29;123(7):1351-604. De Tomaso AW, Nyholm SV, Palmeri KJ, Ishizuka KJ, Ludington WB, Mitchel K, Weissman IL.Isolation and characterization of a protochordate histocompatibility locus.Nature. 2005 Nov 24;438(7067):454-95. Passegu E, Wagne

28、r EF, Weissman IL.JunB deficiency leads to a myeloproliferative disorder arising from hematopoietic stem cells.Cell. 2004 Oct 29;119(3):431-43. 第六位：David T. Scadden, M.D.Director, Center for Regenerative Medicine, Massachusetts General Hospital，Co-Director, Harvard Stem Cell Institute, Harvard Unive

29、rsity。麻省总医院再生医学研究所所长，哈佛大学干细胞研究所共同所长代表作文章1. Janzen V, Forkert R, Fleming HE, Saito Y, Waring MT, Dombkowski DM, Cheng T, DePinho RA, Sharpless NE, Scadden DT.Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a.Nature. 2006 Sep 28;443(7110):421-6.2. Scadden DT.The stem-cell nic

30、he as an entity of action.Nature. 2006 Jun 29;441(7097):1075-9；3. Adams GB, Chabner KT, Alley IR, Olson DP, Szczepiorkowski ZM, Poznansky MC, Kos CH, Pollak MR, Brown EM, Scadden DT.Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor.Nature. 2006 Feb 2;439(7076)

31、:599-603；4. Johnson J, Bagley J, Skaznik-Wikiel M, Lee HJ, Adams GB, Niikura Y, Tschudy KS, Tilly JC, Cortes ML, Forkert R, Spitzer T, Iacomini J, Scadden DT, Tilly JL.Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood.Cell. 2005 Jul 29;122(2):303-155. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, Martin RP, Schipani E, Divieti P, Bringhurst FR, Milner LA, Kronenberg HM, Scadden DT.Osteoblastic cells regulate the haematopoietic stem cell niche.Nature. 2003 Oct 23;425(6960):841-6。并列第六位Sean Morrison, PhD密