一些常用的SCI论文句式Word格式.doc

1、1The mechanisms governing the homeostasis of memory T cells have been an area of intense investigation.2Extensive work has been done in the area of cytokine signaling.3Not unexpectedly, the newest lineage of helper T cells, TH-17 cells, also received a great deal of attention at the Ringberg meeting

2、.4. While the interactions of DC with naive T cells within LN have been analysed in detail,5. While interactions of DC with naive T cells in LN have been extensively examined by 2P-IVM,6. Although the signals that control neutrophil migration from the blood to sites of infection have been well chara

3、cterized, little is known about their migration patterns within lymph nodes or the strategies that neutrophils use to find their local sites of action.不像B，which，A1. Unlike naive T cells, which survive largely in interphase, memory T cells persist under normal conditions with a slow but constant turn

4、over.像一样1As with naive T cells, memory T cells are also capable of undergoing more rapid cell division under lymphopenic conditions, known as acutehomeostatic proliferation.已有共识1There is now a general consensus that two members of the common chain cytokine family, namely IL-7 and IL-15, control the

5、homeostasis of CD8+memory cells仍不清楚1. However, the factors that govern the homeostasis of CD4+ memory cells have yet to be fully defined.2. Although molecular details of the process are poorly understood.3. Although why this subset of T cells is uniquely sensitive to IL-2 is currently unclear.4. exp

6、eriments directly interrogating the physiological requirementsfor DC-produced IL-2 have yet to be published.5. Among the questions that remain to be resolved arehow IL-2 may play both supportive and restrictive roles in the same transgenic OT-1 CD8+ T cells.6. The cause of this disease has been elus

7、ive because the SAP gene is not affected in XLP 2 patients.7The main source of IL-17 at the local site of inflammation still remains unknown.8. Whether such a mechanism is relevant to CD4+ T helper cells remains an open issue.9. Whether the failure to silence TRAIL synthesis upon rechallenge explain

8、s this example of AICD remains to be investigated.10. Whether the receiving cell must make contact with the producing cell or whether there is a role for soluble IL-15/IL-15R complexes in CD8+ memory T cell homeostasis is not clear.11. But the question of whether they need tonic signals via their TC

9、R is still open.12. Exactly what CD4+ T cells provide to maintain CD8+ T cell memory remains a mystery.13 Large questions remain as to how chemokine signaling regulates or is regulated to coordinate the complex in vivo dynamics of the T lymphocytes。14. However, what has not been delineated is the re

10、sponse of effector T cells at nonlymphoid tissue sites when they reencounter Ag.15. The precise role of IL-2 in the regulation of CD8 T cell responses to foreign Ag in vivo however remains enigmatic.16Our understanding of the developmentalcontrol of V（D）J recombination on the one hand, and that of c

11、ell proliferation, death, and survival during differentiationon the other, is still fragmentary.已经得到公认1It is well accepted that two cytokines, namely IL-7 and IL-15, are involved in maintaining the numbers of CD8 memory cells in vivo （145147）.与相似1In addition, there is a high-affinity receptor for IL

12、-15, referred to as IL-15R, and it was thought, in analogy with the IL-2R, that a three-chain complex, , was the receptor for IL-15 on NK cells and memory CD8+ T cells.仍存在争议1It was clear that there is no shortage of controversy.可以肯定地说1It is safe to say, in fact, that there is a long way to go before

13、 the field fully understands the process of effector and memory cell differentiation, the relationships among these post-activation cell fates and the extent to which any given T cell adopts a fixed versus a flexible functional program after antigen activation.2. There is no doubt immunological rese

14、arch has been boosted by therecent application of 2P-IVM依赖、需要1Ag-specifi c memory CD8+ cells, on the other hand, are less dependent on IL-15, relying more on IL-7, but still require IL-15 for basal homeostatic proliferation and long-term maintenance2Furthermore, robust CD8 recall responses appear to

15、 be particularly reliant on CD8 costimulation via 4-1BB.A与B之间的差异1The discrepancy in the homeostatic requirements for Ag-specifi c memory versus MP cells appears even greater for CD4+ than CD8+ cells.与一致,相符1Consistent with this notion, recent studies have shown that IL-7 is essential for the survival and basal homeostatic turnover of Ag-specific CD4+memory cells.2. Similarly broad expression of IL-2 and IL-15 receptors do not coincide well with the highly restricted roles t