美国药典色谱柱分类.docx

美国药典色谱柱分类.docx

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美国药典色谱柱分类

L1—Octadecylsilanechemicallybondedtoporoussilicaorceramicmicro-particles,3to10µmindiameter.

L2—Octadecylsilanechemicallybondedtosilicagelofacontrolledsurfaceporositythathasbeenbondedtoasolidsphericalcore,30to50µmindiameter.

L3—Poroussilicaparticles,5to10µmindiameter.

L4—Silicagelofcontrolledsurfaceporositybondedtoasolidsphericalcore,30to50µmindiameter.

L5—Aluminaofcontrolledsurfaceporositybondedtoasolidsphericalcore,30to50µmindiameter.

L6—Strongcation-exchangepacking–sulfonatedfluorocarbonpolymercoatedonasolidsphericalcore,30to50µmindiameter.

L7—Octylsilanechemicallybondedtototallyporoussilicaparticles,3to10µmindiameter.

L8—Anessentiallymonomolecularlayerofaminopropylsilanechemicallybondedtototallyporoussilicagelsupport,10µmindiameter.

L9—10-µmirregularorspherical,totallyporoussilicagelhavingachemicallybonded,stronglyacidiccation-exchangecoating.

L10—Nitrilegroupschemicallybondedtoporoussilicaparticles,3to10µmindiameter.

L11—Phenylgroupschemicallybondedtoporoussilicaparticles,5to10µmindiameter.

L12

—Astronganion-exchangepackingmadebychemicallybondingaquaternaryaminetoasolidsilicasphericalcore,30to50µmindiameter.

L13—Trimethylsilanechemicallybondedtoporoussilicaparticles,3to10µmindiameter.

L14—Silicagel10µmindiameterhavingachemicallybonded,stronglybasicquaternaryammoniumanion-exchangecoating.

L15—Hexylsilanechemicallybondedtototallyporoussilicaparticles,3to10µmindiameter.

L16—Dimethylsilanechemicallybondedtoporoussilicaparticles,5to10µmindiameter.

L17—Strongcation-exchangeresinconsistingofsulfonatedcross-linkedstyrene-divinylbenzenecopolymerinthehydrogenform,7to11µmindiameter.

L18—Aminoandcyanogroupschemicallybondedtoporoussilicaparticles,3to10µmindiameter.

L19—Strongcation-exchangeresinconsistingofsulfonatedcross-linkedstyrene-divinylbenzenecopolymerinthecalciumform,about9µmindiameter.

L20—Dihydroxypropanegroupschemicallybondedtoporoussilicaparticles,5to10µmindiameter.

L21—Arigid,sphericalstyrene-divinylbenzenecopolymer,5to10µmindiameter.

L22

—Acation-exchangeresinmadeofporouspolystyrenegelwithsulfonicacidgroups,about10µminsize.

L23—Ananion-exchangeresinmadeofporouspolymethacrylateorpolyacrylategelwithquaternaryammoniumgroups,about10µminsize.

L24—Asemi-rigidhydrophilicgelconsistingofvinylpolymerswithnumeroushydroxylgroupsonthematrixsurface,32to63µmindiameter.5

L25—Packinghavingthecapacitytoseparatecompoundswithamolecularweightrangefrom100–5000（asdeterminedbypolyethyleneoxide）,appliedtoneutral,anionic,andcationicwater-solublepolymers.Apolymethacrylateresinbase,cross-linkedwithpolyhydroxylatedether（surfacecontainedsomeresidualcarboxylfunctionalgroups）wasfoundsuitable.

L26—Butylsilanechemicallybondedtototallyporoussilicaparticles,5to10µmindiameter.

L27—Poroussilicaparticles,30to50µmindiameter.

L28—Amultifunctionalsupport,whichconsistsofahighpurity,100Å,sphericalsilicasubstratethathasbeenbondedwithanionicexchanger,aminefunctionalityinadditiontoaconventionalreversedphaseC8functionality.

L29—Gammaalumina,reverse-phase,lowcarbonpercentagebyweight,alumina-basedpolybutadienesphericalparticles,5µmindiameterwithaporevolumeof80Å.

L30—Ethylsilanechemicallybondedtototallyporoussilicaparticles,3to10

µmindiameter.

L31—Astronganion-exchangeresin-quaternaryaminebondedonlatexparticlesattachedtoacoreof8.5-µmmacroporousparticleshavingaporesizeof2000Åandconsistingofethylvinylbenzenecross-linkedwith55%divinylbenzene.

L32—Achiralligand-exchangepacking–L-prolinecoppercomplexcovalentlybondedtoirregularlyshapedsilicaparticles,5to10µmindiameter.

L33—Packinghavingthecapacitytoseparatedextransbymolecularsizeoverarangeof4,000to500,000Da.Itisspherical,silica-based,andprocessedtoprovidepHstability.6

L34—Strongcation-exchangeresinconsistingofsulfonatedcross-linkedstyrene-divinylbenzenecopolymerintheleadform,about9µmindiameter.

L35—Azirconium-stabilizedsphericalsilicapackingwithahydrophilic（diol-type）molecularmonolayerbondedphasehavingaporesizeof150Å.

L36—A3,5-dinitrobenzoylderivativeofL-phenylglycinecovalentlybondedto5-µmaminopropylsilica.

L37—Packinghavingthecapacitytoseparateproteinsbymolecularsizeoverarangeof2,000to40,000Da.Itisapolymethacrylategel.

L38—Amethacrylate-basedsize-exclusionpackingforwater-solublesamples.

L39—Ahydrophilicpolyhydroxymethacrylategeloftotallyporoussphericalresin.

L40—Cellulosetris-3,5-dimethylphenylcarbamatecoatedporoussilicaparticles,5to20

µmindiameter.

L41—Immobilizeda1-acidglycoproteinonsphericalsilicaparticles,5µmindiameter.

L42—Octylsilaneandoctadecylsilanegroupschemicallybondedtoporoussilicaparticles,5µmindiameter.

L43—Pentafluorophenylgroupschemicallybondedtosilicaparticlesbyapropylspacer,5to10µmindiameter.

L44—Amultifunctionalsupport,whichconsistsofahighpurity,60Å,sphericalsilicasubstratethathasbeenbondedwithacationicexchanger,sulfonicacidfunctionalityinadditiontoaconventionalreversedphaseC8functionality.

L45—Betacyclodextrinbondedtoporoussilicaparticles,5to10µmindiameter.

L46—Polystyrene/divinylbenzenesubstrateagglomeratedwithquaternaryaminefunctionalizedlatexbeads,10µmindiameter.

L47—High-capacityanion-exchangemicroporoussubstrate,fullyfunctionalizedwithtrimethlyaminegroups,8µmindiameter.7

L48—Sulfonated,cross-linkedpolystyrenewithanouterlayerofsubmicron,porous,anion-exchangemicrobeads,15µmindiameter.

L49—Areversed-phasepackingmadebycoatingathinlayerofpolybutadieneontosphericalporouszirconiaparticles,3to10µmindiameter.8

L50—Multifunctionresinwithreversed-phaseretentionandstronganion-exchangefunctionalities.Theresinconsistsofethylvinylbenzene,55%cross-linkedwithdivinylbenzenecopolymer,3to15

µmindiameter,andasurfaceareanotlessthan350m2perg.Substrateiscoatedwithquaternaryammoniumfunctionalizedlatexparticlesconsistingofstyrenecross-linkedwithdivinylbenzene.9

L51—Amylosetris-3,5-dimethylphenylcarbamate-coated,porous,spherical,silicaparticles,5to10µmindiameter.10

L52—Astrongcationexchangeresinmadeofporoussilicawithsulfopropylgroups,5to10µmindiameter.11

L53—Weakcation-exchangeresinconsistingofethylvinylbenzene,55%cross-linkedwithdivinylbenzenecopolymer,3to15µmdiameter.Substrateissurfacegraftedwithcarboxylicacidand/orphosphoricacidfunctionalizedmonomers.Capacitynotlessthan500µEq/column.12

L54—Asizeexclusionmediummadeofcovalentbondingofdextrantohighlycross-linkedporousagarosebeads,about13µmindiameter.13

L55—Astrongcation-exchangeresinmadeofporoussilicacoatedwithpolybutadiene–maleicacidcopolymer,about5µmindiameter.14

L56—Isopropylsilanechemicallybondedtototallyporoussilicaparticles,3to10µmindiameter.15

L57—Achiral-recognitionprotein,ovomucoid,chemicallybondedtosilicaparticles,about5µmindiameter,withaporesizeof120Å.

L58—Strongcation-exchangeresinconsistingofsulfonatedcross-linkedstyrene-divinylbenzenecopolymerinthesodiumform,about7to11

µmindiameter.16

L59—Packinghavingthecapacitytoseparateproteinsbymolecularweightovertherangeof10to500kDa.Itisspherical（10µm）,silica-based,andprocessedtoprovidehydrophiliccharacteristicsandpHstability.17USP28

L60—Spherical,poroussilicagel,3or5µmindiameter,thesurfaceofwhichhasbeencovalentlymodifiedwithpalmitamidopropylgroupsandendcappedwithacetamidopropylgroupstoaliganddensityofabout6µmolesperm2.18USP28

L1是C18柱

L1：

十八烷基键合多孔硅胶或无机氧化物微粒固定相，简称ODS柱

L2：

30～50mm表面多孔薄壳型键合十八烷基固定相，简称C18柱

L3：

多孔硅胶微粒，即一般的硅胶柱

L4：

30～50mm表面多孔薄壳型硅胶柱

L5：

30～50mm表面多孔薄壳型氧化铝柱

L6：

30～50mm实心微球表面包覆磺化碳氟聚合物，强阳离子交换柱

L7：

全多孔硅胶微粒键合C8官能团固定相，简称C8柱

L8：

全多孔硅胶微粒键合非交联NH

2固定相，简称NH2柱

L9：

强酸性阳离子交换基团键合全多孔不规则形硅胶固定相，即SCX柱

L10：

多孔硅胶微球键合氰基固定相（CN），简称CN柱

L11：

键合苯基多孔硅胶微球固定相，简称苯基柱

L12：

无孔微球键合季胺功能团的强阴离子交换柱

L13：

三乙基硅烷化学键合全多孔硅胶微球固定相（C1），简称C1柱

L14：

10mm硅胶化学键合强碱性季铵盐阴离子交换固定相，简称SAX柱

L15：

已基硅烷化学键合全多孔硅胶微球固定相，简称C6柱

L16：

二甲基硅烷化学键合全多孔硅胶微粒固定相C2柱

L17：

氢型磺化交联苯乙烯-二乙烯基苯共聚物,强阳离子交换柱

L18：

3～10mm全多孔硅胶化学键合胺基（NH

2）和氰基（CN）柱

L19：

钙型磺化交联苯乙烯－二乙烯基苯共聚物，强阳离子交换柱

L20：

二羟基丙烷基化学键合多孔硅胶微球固定相（Diol），简称二醇基柱

L21：

刚性苯乙烯－二乙烯基苯共聚物微球填料柱

L22：

带有磺酸基团的多孔苯乙烯阳离子交换柱

L23：

带有季胺基团的聚甲基丙烯酸甲酯或聚丙烯酸酯多孔离子交换柱

L24：

表面含有大量羟基的半刚性聚乙烯醇亲水凝胶柱

L25：

聚甲基丙烯酸酯树脂交联羟基醚（表面含有残余羧基功能团）树脂。

能分离分子量100～5000MW范围的水溶性中性、阳离子型及阴离子型聚合物（用聚氧乙烯测定）的固定相

L26：

丁基硅烷化学键合全多孔硅胶微球固定相，即C4柱

L27：

30～50mm的全多孔硅胶微粒

L28：

多功能载体，100?

的高纯硅胶加以氨基键合以及C8反相键合的官能团

L29:

氧化铝,反相键合,含碳量低,氧化铝基聚丁二稀小球,5mm，孔径80?

L30:

全多孔硅胶键合乙基硅烷固定相

L31:

季胺基改性孔径2000?

的交联苯乙烯和二乙烯基苯（55%）强阴离子交换树脂

L32:

L-脯氨酸铜配合物共价键合于不规则形硅胶微粒的配位体的交换手性色谱填料

L33:

能够分离分子量4000～40000MW范围

蛋白质分子的球形硅胶固定相,pH稳定性好

L34：

铅型磺化交联苯乙烯－二乙烯基苯共聚物强阳离子交换树脂，9mm球形

L35：

锆稳定的硅胶微球键合二醇基亲水分子单层固定相，孔径150?

L36:

5mm胺丙基硅胶键合L-苯基氨基乙酸－3,5二硝基苯甲酰

L37：

适合分离分子量2000～40000MW的聚甲基丙烯酸酯凝胶

L38：

水溶性甲基丙烯酸酯基质SEC色谱柱

L39：

亲水全多孔聚羟基甲基丙烯酸酯色谱柱

L40：

Tris3,5－二甲基苯基氨基甲酸酯纤维素涂覆多孔硅胶微球

L41：

球形硅胶表面固定

α1酸糖蛋白固定相

L42:

C8和C18硅烷化学键合多孔硅胶固定相

L43:

硅胶微球键合五氟代苯基固定相

L44:

多功能固定相,60?

高纯硅胶基质键合磺酸阳离子交换功能团和C8反相功能团

L45:

β-环糊精键合多孔硅胶微球

L46:

季胺基改性苯乙烯-二乙烯基苯聚合物微球

L1Octadecylsilanechemicallybondedtoporoussilicaorceramic.

L1十八烷基键合硅烷化学键合于多孔硅胶或陶瓷微粒，3-10u。

L2Octadecylsilanechemicallybondedtosilicagelofacontrolledsurfaceporositythathasbeenbondedtoasolidsphericalcore,30to50μmindiameter.

L2十八烷基键合硅烷化学键合于表面空隙率一定的键合在紧密球核上的硅胶，粒径30-50u。

L3Poroussilicaparticles,5to10

μmindiameter.

L3多孔硅胶颗粒，粒径5-10u。

L4Silicagelofcontroll