FTD patients were impaired by lexicalsemantic syntactic and more especially by pragmatic problems.docx

FTD patients were impaired by lexicalsemantic syntactic and more especially by pragmatic problems.docx

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FTDpatientswereimpairedbylexicalsemanticsyntacticandmoreespeciallybypragmaticproblems

138

Theimpactofelectronicmedicalrecordsystemsonoutpatientworkflows:

Alongitudinalevaluationofitsworkfloweffects  OriginalResearchArticle

InternationalJournalofMedicalInformatics,Volume79,Issue11,November2010,Pages778-791

ArunVishwanath,SandeepRajanSingh,PeterWinkelstein

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139

Auniformobject-orientedsolutiontotheeigenvalueproblemforrealsymmetricandHermitianmatrices  OriginalResearchArticle

ComputerPhysicsCommunications,InPress,CorrectedProof,Availableonline25November2010

MaríaEugeniaCastro,JavierDíaz,CameliaMuñoz-Caro,AlfonsoNiño

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140

TheFedosov*-productinMathematica  OriginalResearchArticle

ComputerPhysicsCommunications,Volume181,Issue3,March2010,Page704

JaromirTosiek

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141

EfficientsiRNAdeliverybasedonPEGylatedandpartiallyquaternizedpolyaminenanogels:

Enhancedgenesilencingactivitybythecooperativeeffectoftertiaryandquaternaryaminogroupsinthecore  OriginalResearchArticle

JournalofControlledRelease,Volume146,Issue3,15September2010,Pages378-387

AtsushiTamura,MotoiOishi,YukioNagasaki

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Graphicalabstract

142

CodeC#forchaosanalysisofrelativisticmany-bodysystems  OriginalResearchArticle

ComputerPhysicsCommunications,Volume181,Issue8,August2010,Pages1464-1470

I.V.Grossu,C.Besliu,Al.Jipa,C.C.Bordeianu,D.Felea,E.Stan,T.Esanu

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143

Comparisonofmethodsforintegratingbiologicalandphysicaldataformarinehabitatmappingandclassification  OriginalResearchArticle

ContinentalShelfResearch,Volume30,Issue16,30September2010,Pages1717-1729

E.J.Shumchenia,J.W.King

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AbstractAbstract|Figures/TablesFigures/Tables|ReferencesReferences

Abstract

Animportantfirststepinmarinespatialplanningandecosystem-basedmanagementeffortsisthecreationofbenthichabitatmapsthatallowscientistsandmanagerstounderstandthedistributionoflivingandnon-livingresourcesontheseafloor.However,thelocationofboundariesbetweenandcompositionofhabitatsishighlydependentontheapproachtakentointegrateabioticandbioticinformation.Thepurposeofthisstudywastotest“top-down”and“bottom-up”approachesforintegratingphysicalandbiologicaldataderivedfromcommonlyusedsub-tidalbenthicmappingtoolstocreateahabitatmapcompatiblewiththeUSCoastalandMarineEcologicalClassificationStandard（CMECS）.Wefoundthatatop-downframework,wherewetestedfordifferencesinmacrofaunaassemblagesamongsidescansonarfacies,definedtwobroad-scaleandgeneralhabitats.Usingthebottom-upapproach,wherepatternsinabioticandbioticvariableswereexaminedwithmultivariatestatistics（BEST,LINKTREE,ANOSIM,SIMPER）,wegeneratedsevenbiotopesbasedonthemacrofaunaabundance,percentsand,waterdepth,andbackscatterstandarddeviationthatcorrespondedwellto,butprovidedmorefine-scaledetailthanthetop-downhabitats.WewereabletousethestatisticalrelationshipbetweenabioticvariablesandmacrofaunaassemblagesintheLINKTREEtopredictthespatialdistributionofassemblagesover

50%ofthestudyarea.WecreatedalocalcatalogueofbiotopesspecifictoourstudyareathatcontributestotheCMECSlibrary.Inaddition,wewereabletofullymapCMECSGeoform,SurfaceGeology,andBioticCoverComponents.Thismappingeffortrepresentedrealprogresstowardreconcilingthe“datadensitymismatch”betweenphysicalandbiologicalmappingmethods,anditprovidedfurtherevidencethatusingabottom-upmethodologypreservesspecies–environmentrelationships.

ArticleOutline

1.Introduction

2.Methods

2.1.Acousticdata

2.2.Bathymetry

2.3.Bottomsamples

2.3.1.Sedimentproperties

2.3.2.Macrofaunaassemblages

2.4.Integrationofacousticdatawithsedimentandmacrofaunadata

2.4.1.Top-downapproach:

dotheacousticfaciesdescribedistinctmacrofaunaassemblages?

2.4.2.Bottom-upapproach:

whichacousticandabioticvariablesarerelatedtopatternsinmacrofaunaassemblages?

2.5.Mappingandclassification

3.Results

3.1.Acousticdata

3.2.Macrofaunaassemblages

3.3.Dataintegration

3.3.1.Top-down

3.3.2.Bottom-up

3.4.Mapping

3.5.Classification

3.5.1.Surfacegeologycomponent,bioticcovercomponent（SGC,BCC）

3.5.2.Geoformcomponent（GFC）

4.Discussion

4.1.Acousticdata

4.2.Integrationapproaches

4.3.Biotic–abioticrelationshipsandbiologicalassemblageprediction

4.4.Habitatclassification

5.Conclusions

Acknowledgements

References

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144

InternationalcollaborationbetweenUSandThailandonaclinicaltrialoftreatmentforHIV-associatedcryptococcalmeningitis  OriginalResearchArticle

ContemporaryClinicalTrials,Volume31,Issue1,January2010,Pages34-43

L.O.Zimmer,T.L.Nolen,S.Pramanpol,D.Wallace,M.E.Walker,P.Pappas,P.Chetchotisakd

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AbstractAbstract|Figures/TablesFigures/Tables|ReferencesReferences

Abstract

Background

Internationalclinicaltrialscanprovidescientificandlogisticbenefitsinspiteofthemanychallenges.Determiningwhetheracountry,especiallyadevelopingcountry,isanappropriatelocationfortheresearchshouldincludein-countryconsultationandpartneringtoassessitssocialvalueforthepopulation;thattreatmentsarerelevantforthepopulationunderstudy;andthattheresearchinfrastructureandethicaloversightareadequate.Collaborationincreasesthelikelihoodofstudysuccessandhelpsensurethatbenefitsaccruetorecruitedpopulationsandtheircommunity.

Purpose

Thispaperdescribesourexperiencesonabi-nationalstudyandmayprovideguidanceforthoseplanningtoengageinfuturecollaborations.

Methods

AThaiandUnitedStatesteamcollaboratedtodevelopandimplementaphaseIIclinicaltrialforHIV-associatedcryptococcalmeningitistoassesssafetyandtolerabilityofcombinationtherapyvs.standardtreatment.Clinicalandculturaldifferences,regulatoryhurdlesandoperationalissueswereaddressedbeforeandduringthestudytoensureasuccessfulcollaborationbetweenthe2groups.

Results

Theinternationalmulticenterstudyallowedformorerapidenrollment,reducedcoststocompletethestudy,sharingofthebenefitsofresearch,greatergeneralizabilityofresultsandcapacitybuildinginThailand;qualitymetricsinThailandwereequivalenttoorbetterthanthoseintheU.S.

Conclusions

Conductingsuccessfulclinicaltrialsinternationallyrequiresearlyandongoingcollaborationtoensurethestudymeetssites'requirementsandexpectations,conformstovaryingnationalregulations,adherestodataqualitystandardsandisresponsivetothehealthneedsofstudiedpopulations.

ArticleOutline

1.Introduction

1.1.Diseaseandtrialbackground

2.Methods

2.1.Selectionofoverseaspopulation

2.2.Developmentofstudyinfrastructureanddesignandimplementation

2.2.1.Protocoldevelopment

2.2.2.Siteassessment,trainingandprotocolrefinement

2.2.3.Studymaterialsandprocesses

2.2.4.Shippingofdrugandsupplies

2.3.Ethicaloversight

2.4.Ongoingoversightofsiteperformance

3.Qualityofstudyresults

3.1.Measuresofstudyimplementationandsubjectdispositionandcompliance

3.2.Datasubmission

3.3.Dataquality

4.Discussion

4.1.Benefits

4.2.Challenges

5.Conclusions

Conflictofintereststatement

Acknowledgements

References

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145

Developmentofinhibitorycontrolamongprenatallycocaineexposedandnon-cocaineexposedyouthsfromlatechildhoodtoearlyadolescence:

Theeffectsofgenderandriskandsubsequentaggressivebehavior  OriginalResearchArticle

NeurotoxicologyandTeratology,Volume33,Issue1,January-February2011,Pages47-60

DavidJ.Bridgett,LindaC.Mayes

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146

PlasmacontrolsystemupgradeandincreasedplasmastabilityinNSTX  OriginalResearchArticle

FusionEngineeringandDesign,Volume85,Issues3-4,July2010,Pages447-450

D.Mastrovito,D.Gates,S.Gerhard,J.Lawson,C.Ludescher-Furth,R.Marsala

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147

Theimpactofthenewtechnologiesinforeignlanguageinstructionourexperience  OriginalResearchArticle

Procedia-SocialandBehavioralSciences,Volume2,Issue2,2010,Pages1185-1189

AnisoaraPop

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AbstractAbstract|ReferencesReferences

Abstract

AlthoughXXIstcenturyeducationhasbecomeincreasinglypermeabletotechnologyhelpingstudentstoacquireskillsneededtoexistinahighlytechnologicalknowledge-basedsociety,foreignlanguageinstructionisstillresistanttoemploymento