最新药理学英文习题教研室版.docx

最新药理学英文习题教研室版.docx

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最新药理学英文习题教研室版

Ⅰ.ChoiceQuestions

TypeA

1.Thehalf-lifeofadrugis2hours,howmuchistheK?

A.0.1（h-1）

B.0.2（h-1）

C.0.3（h-1）

D.0.35（h-1）

E.2（h-1）

2.Whichofthefollowingstatementsaboutfirst-orderkineticseliminationistrue?

A.Theeliminationrateisfast

B.Theeliminationrateisslow

C.Thereisnorelationshipbetweentheamountofdruginthebody

andeliminationrate

D.Theeliminationofdrugisindirectproportiontotheblood

concentrationofthedrug

E.Theeliminationofdrugisininverseratiototheamountofdrug

inthebody

3.Asfarassomedrugisconcerned,whichofthefollowingstatementsconcerningthedrug'scombinationwithplasmaproteinistrue?

A.Thehigherthebindingrate,thestrongerthecurativeeffect

B.Thelowerthebindingrate,thestrongerthecurativeeffect

C.Thehigherthebindingrate,thefastertheexcretion

D.Thereisnotrelationshipbetweenbindingrateandcurativeeffect

E.Alloftheaboveareincorrect

4.Whichofthefollowingadministrationscanimmediatelyreachtheplateauconcentration?

A.Decreasingdose,increasingtimesofadministration

B.Decreasingadministeringinterval

C.Increasingadministeringinterval

D.Administrationofloadingdose

E.Frequentadministrationbyiv

5.Ingeneral,theweakaciddrugsinbasicsolutionare

A.weaklyionized,passacrossthebiomembraneeasily

B.stronglyionized,passacrossthebiomembraneeasily

C.stronglyionized,passacrossthebiomembranehardly

D.weaklyionized,passacrossthebiomembranehardly

E.allofaboveareincorrect

6.IfthestomachjuicepHis1.4andplasmapHis7.4,howmuchisthedrugconcentrationratioofplasmatostomachjuiceforaweakacidicdrugwithpKa5.4whenthedistributionreachtoequilibrium？

A.50

B.100

C.1000

D.10000

E.0.1

7.AllofthefollowingstatementsareapplicabletothesublingualrouteofadministrationEXCEPT

A.plasmaconcentrationdecreasedbyfirstpasselimination

B.lipidsolubledrugswillbeabsorbedrapidly

C.Irritantdrugsshouldnotbegivenbythisroute

D.bloodflowthroughthemucosaishigh

E.tasteofdrugslimitstheusefulnessofthisroute

8.Whichofthefollowingcanbeadvisabletotreathemorrhageofdigestivetract?

A.Norepinephrineoraladministration

B.Norepinephrineivadministration

C.Norepinephrineimadministration

D.Norepinephrinesubcutaneousinjection

E.Adrenalineoraladministration

9.Phentolaminecanmostlikelybeusedtotreat

A.peripheralarterialspasm

B.anginapectoris

C.arrhythmia

D.hypertension

E.pepticulcer

10.Whichofthefollowingdrugscanbeusedtotreatintoxicationofsuccinylcholine?

A.Neostigmine

B.Atropine

C.Adrenaline

D.Pyraloximemethiodide

E.Nikethamide

11.Whichofthefollowingdrugscanbeadministeredsublinguallyorinhaledintreatingbronchiasthma?

A.Adrenaline

B.Isoprenaline

C.Ephedrine

D.Phenylephrine

E.Aminophylline

12.Afterinjectionofpropranolol,theinfluenceofphentolamineonbloodpressureis

A.firstup,thendown

B.uponly

C.downonly

D.firstdown,thenup

E.thesameasbefore

13.Whichofthefollowingdrugscouldpassthroughtheblood-brainbarrierandcauseinsomnia?

A.Adrenaline

B.Dopamine

C.Ephedrine

D.Isoprenaline

E.Norepinephrine

14.Whichofthefollowingisnotthecontraindicationofβ-receptorblockers?

A.chronicheartfailure

B.atrioventricularblock

C.bronchialasthma

D.highbloodpressure

E.sinusbradycardia

15.Whichofthefollowingdrugswouldbeusedtotreatmyastheniagravis?

A.Atropine

B.Neostigmine

C.Acetylcholine

D.Scopolamine

E.Carbachol

16.Whichofthefollowingsympathomimeticagentswillmostlikely

leadtoarrhythmiaandventricularfibrillation?

A.Ephedrine

B.Adrenaline

C.Metaraminol

D.Dopamine

E.Norepinephrine

17.Inwhichofthefollowingconditionsatropinecanmostlikelybecontraindicated

A.Glaucoma

B.Intestinalspasm

C.Infectiveshock

D.Iridocyclitis

E.Allofabove

18.Whichofthefollowingdrugscanbeusedtotreatheartcardiacfailure

causedbymyocardialinfarction?

A.Atropine

B.Isoprenaline

C.Dobutamine

D.Norepinephrine

E.Ephedrine

19.Whichofthefollowingdrugsisapplicabletotreatallergicshock?

A.Isoproterenol

B.Adrenaline

C.Norepinephrine

D.Phenoxybenzamine

E.Atropine

20.AllofthefollowingstatementsabouttheactionofneosynephrinearetrueEXCEPT

A.longeffectivespan

B.itisstrongerthanNEindecreasingtherenalbloodflow

C.mydriasis

D.itisn'tusedtoenhancetheintraocularpressure

E.itcanbeusedtotreatparoxysmalsupraventriculartachycardia

21.Whichofthefollowingdrugscanmostlikelybeusedtotreatinfectiveshock

andintractableheartfailure?

A.Isoprenaline

B.Phentolamine

C.Phenoxybenzamine

D.Reserpine

E.Atropine

22.Renalvasodilationcausedbydopamineisbecause

A.itstimulatestherenalα-receptor

B.itstimulatestherenalβ1-receptor

C.itstimulatestherenalβ2-receptor

D.itstimulatestherenalDAreceptors

E.itstimulatestherenalDAandMreceptors

23.Apatientwhohas"spasmsofaccommodation"、miosis、increased

sweatingandexcessivesalivationmayhavebeengiven

A.aganglionicblockingdrug

B.amuscarinicblockingdrug

C.ananticholinesterasedrug

D.aβ1-adrenoceptorblockingdrug

E.anα-adrenoceptorblockingdrug

24.Whichofthefollowingtherapeuticprojectswouldbeusedinthetreatmentofpatientwith

seriousorganophosphateintoxication?

A.Atropine

B.Atropine+neostigmine

C.Atropine+pyraloximemethoiodide

D.Atropine+norepinephrine

E.Pyraloximemethoiodide

25.Whichofthefollowingdrugscanbeusedintreatingthepatientwithatrioventricularblock?

A.adrenaline

B.noradrenaline

C.isoprenaline

D.aramine

E.propranolol

26.WhichofthefollowingM-receptorblockerscanbeusedinthetreatmentofmotionsicknessandParkinsonism?

A.atropine

B.anisodamine

C.scopolamine

D.homatropine

E.propantheline

27.Whenphenobarbitalpoisoning,inordertoreducingtoxicityandpromotingtoxicsubstanceexcretion,weshould

A.applyacidicdrugtodecreasethepHofplasmaandurine

B.applybasicdrug,toincreasethepHofplasmaandurine

C.infuseintravenouslydextran40

D.administernormalsalinesolution

E.administer10%glucoseintravenously

28.Whichofthefollowingstatementsaboutextrapyramidalsyndrome

causedbychlorpromazineiscorrect?

A.BlockingofDAreceptorsonnigrostriatalpathway

B.BlockingofDAreceptorsonmiddlebrain-limbicsystempathway

C.BlockingofDAreceptorsonmiddlebrain-cortexpathway

D.BlockingofDAreceptorsonnoduleinfundibularpathway

E.Alloftheaboveareincorrect

29.Lithiumcarbonatecanbeusedintreatingmaniacbecause

A.itincreasesthereleaseofNAinbrain

B.itinhibitsthereleaseofNAandDA,andpromotesthereabsorption

ofNAandDA

C.itincreasesthesynthesisofNAinbrain

D.itdecreasesthesynthesisofNAinbrain

E.itdecreasesthesynthesisofNAandDAinbrain

30.Whichofthefollowingisthedrugchoiceforstatusepilepticus?

A.phenobarbital

B.phenytoinsodium

C.valproatesodium

D.carbamazepine

E.diazepam

31.Totreatcardiacasthmawecanselect

A.isoprenaline

B.asdrenaline

C.pethidine

D.atropine

E.ephedrine

32.Whichofthefollowinganalgesicdrugscanbeusedinartificialhibernation?

A.pethidine

B.morphine

C.anadol

D.methadone

E.fentanyl

33.Theanalgesicmechanismofmorphineis

A.inhibitionofmorphinereceptorsinbrain

B.blockingmorphinereceptorsincenter

C.stimulatingmorphinereceptorsincenter

D.inhibitionofsynthesisofPGinbrain

E.allofaboveareincorrect

34.Thedrugthatcanbeusedintreatingpatientswithvariousdepressionis

A.chlorpromazine

B.promethazine

C.imipramine

D.lithiumcarbonate

E.trifluperazine

35.WhichofthefollowingaboutsavingthephenobarbitalpoisoningisINCORRECT?

A.Infusingnormalsalinesolutioninalargedose

B.Administrationofsodiumbicarbonatetobasifyurine

C.Administrationofstrongdiuretics

D.Administrationofammoniumchloridetoacidifythebodyfluidandurine

E.Washingthestomachinpoisoningearly

36.Whichofthefollowingstatementsaboutthemechanismofaspirin’s

antipyreticeffectistrue?

A.InhibitionofPGsynthesisoftemperatureregulatingcenter

B.InhibitionofDAsynthesisoftemperatureregulatingcenter

C.PromotingofPGsynthesisofthetemperature-regulatingcenter

D.PromotingofDAsynthesisofthetemperature-regulatingcenter

E.Directdilationofbloodvessel,incrementofhotspread

37.Themaincauseofdeathresultingfrommorphinepoisoningis

A.respiratorydepressionB.dehydration

C.cardiacarrestD.shock

E.acuterenalfailure

38.Whichisthedrugchoiceinthetreatmentofabsenceseizures?

A.phenytoinsodium

B.carbamazepine

C.amobarbital

D.ethosuximide

E.glutethimide

39.Whichofthefollowingstatementsaboutlevodopaisincorrect?

A.moreeffectiveforthemildandyoungerpatientswithParkinsonism

B.moreeffectiveforrigidityandakinesia

C.moreeffectivefortremor

D.onsetslow

E.canbeusedinhepaticcoma

40.Themechanismofvasodilationofnitroglycerinis

A.vasodilatingdirectly

B.blockingαreceptor

C.producingNO,makingbloodvesselsdilateafterbindingwithit'sreceptor,

D.stimulating