医学免疫学英语试题文档格式.docx

医学免疫学英语试题文档格式.docx

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A.complementaritydeterminingregions.B.HandLchainvariableregions.C.oneantigenbindingregion.D.oneH-Linterchaindisulfidebond.

5Positiveselectioninthethymusismediatedby:

（A）

Thymicepithelialcells.B 

Macrophages.C 

Dendriticcells.D 

B-cells.

6.TypeⅣhypersentivityisoftenreferredtoas:

（B）

A.ImmediatehypersensitivityB.Delayedhypersensitivity

C.CytotoxichypersensitivityD.Allergichypersensitivity

7.TypeⅡhypersentivityisoftenreferredtoas:

（C）

A.ImmediatehypersensitivityB.Delayedhypersensitivity

C.CytotoxichypersensitivityD.Allergichypersensitivity

8.NaiveBcellexpresses（C）

A.IgAaloneB.IgAandIgGCIgM+IgDD.IgEandIg

9.Tcell-derivedcytokines（D）

A.areantigen-specificproductsofTcellactivation

B.arestoredintherestingTcellandreleasedonactivation

C.areMHC-restrictedintheireffects

D.influencetheclassofantibodiesproducedbyBcell

10.Neutrophilsareattractedtoaninfectedareaby（C）

A.IgMB.C1C.C5aD.C8

11.Complementlysescellsby（C）

A.enzymaticdigestionofthecellmembrane

B.activationofadenylatecyclase

C.insertionofcomplementproteinsintothecellmembrane

D.inhibitionofelongationfactor2

12.CD8isamarkerof（C）

A.BcellsB.Helper-TcellsC.cytotoxicTcellD.Mφ

13.MHCclassⅡmoleculesarefoundon（B）

A.VirtuallyallcellsinthebodyB.Bcells,DCandMφ

C.VirtuallyallnucleatedcellsinthebodyD.Onlyonvirally-infectedcells.

14.AlloffollowingcytokinesaresecretedbyTh2cellsexcept（B）

A.IL-4B.IFN-γC.IL-5D.IL-6

15.WhichofthefollowingisNOTtrueofCD4+andCD8+cellmarkers?

（D）

A.ThesearebothsurfaceglycoproteinsexpressedonT-cells.

B.TheseservetodistinguishdifferenttypesofT-cells,e.g.,helper,suppressorandcytotoxic,fromeachother.

C.Thesearenotfoundassociatedwithimmunoglobulins.

D.BothofthemarkersarepresentonALLT-cells.

16. 

CellsbearingMHCclassIpluspeptidearetargetsforspecific:

B-cells.B 

CytotoxicT-cells.C 

Th1cells.D 

Th2cells.

17.Dendriticcellsarecharacterizedby:

（D）

thepresenceofmajorbasicproteinB 

expressionofCD3C 

expressionofIgMmoleculesD 

theirinterfacebetweentheinnateandadaptiveimmunesystem

18.WhichofthefollowinguniquelydistinguishestheT-cellreceptor（TCR）fromanantibody?

A.TheTCRcanbindanantigenfragmentonlyinatrimolecularcomplexwitheithertheclassIorclassIIsurfaceproteinsofthemajorhistocompatibilitycomplex

B.TheTCRcanfunctionasacellsurfaceantigenreceptor

C.TheTCRiscomposedoftwodifferenttypesofpolypeptidechains

D.TheTCRiscapableofparticipatinginacytotoxicreaction.

19.Acriticalpropertyofanantigenis（A）

A.Itsabilitytostimulateanimmuneresponse

B.auniquetopologicalfeaturecalledanparatope

C.notauniquetopologicalfeaturecalledanantigenicdeterminant

D.thesizeofwhichisrelativelysmall

20.Opsonizationofbacteriaoccursthroughcoatingbacteriajustwith:

C3bB 

C8C 

MembraneattackcomplexD 

IgM

21. 

ThefollowingischaracteristicofB-butnotT-cells:

ClassIMHC.B 

CD3.C 

HIVvirusreceptor.D 

Surfaceimmunoglobulin.

22．WhichofthefollowingmoleculesisexpressedonthesurfaceofmatureCD4+Tcells?

（C）

A.BcellreceptorB.CD1dC.CD3D.CD8

23．Thethymusisthesiteofinitialdifferentiationfor（D）

A.BcellsB.ErythrocytesC.HematopieticstemcellsD.Tcells

24.Themembraneattackcomplexconsistsof:

OHB 

C3b3b,BbC 

C5b,6,7,8,9D 

Properdin

25.TypeⅠhypersentivityisoftenreferredtoas:

（A）

C.CytotoxichypersensitivityD.Immunecomplexhypersensitivity

26.TypeⅢhypersentivityisoftenreferredtoas:

（D）

C.CytotoxichypersensitivityD.Immunecomplexhypersensitivity

27.ThetypeⅠhypersentivityismediatedby:

A.IgAB.IgDC.IgGD.IgE

28.ThecytokinewhichismostinvolvedintheclassswitchtoIgEproductionis:

A.IL-1B.IL-2C.TGFbetaD.IL-4

29.WhichtypehypersensitivityisrelatedtothemechanismofacuteArthusreaction:

A.TypeⅠhypersentivityB.TypeⅡhypersentivity

C.TypeⅢhypersentivityD.TypeⅣhypersentivity

30. 

T-cellCD40LprovidesacostimulatorysignaltoB-cellsbyligating:

CD40B 

MHCclassIIC 

CD28D 

CD19

31.Whichimmunoglobulincanbetransportedthroughtheplacenta?

A.IgGB.IgMC.SecretoryIgAD.IgE

32.Whichimmunoglobulinisthemostoneintheblood?

33.Whichimmunoglobulincanmediatetheimmediatehypersensitivity?

34.MoleculesdirectlyinvolvedinNKcellmediatedkillinginclude:

nitricoxideB 

granzymeC 

complementD 

IFN-γ

35.Immunecomplexesconsistof（C）

A.antibodypluscomplementB.basophilpluscomplement

C.antigenplusantibodyD.antigenpluscomplement

36. 

ThemaincostimulatorysignalforactivationofrestingT-cellsisprovidedbyligationof:

CD28B 

SurfaceIgC 

LFA-1D 

VLA-4

37. 

TheT-cellreceptorantigenrecognitionsignalistransducedby:

（E）

TheTCRalphachain.B 

TheTCRbetachain.D 

CD2.E 

CD3.

38. 

TheT-cellligandbindingB7onaprofessionalantigen-presentingcellis:

A

CD28B 

CD2C 

ICAM-1

39. 

Secondaryantibodyresponsesarebetterbecause:

（C）

Theyprovidedefenseagainstunrelatedantigens

B 

TheantibodycanbemadebybothTandBcells

C 

Theyarestrongerandfaster

D 

TheydonotrequireT-cellhelp

40. 

Whichcelltypeproducesantibodies?

:

MacrophagesB 

T-lymphocytesC 

NKD 

Plasmacells

II.Indicatewhethereachofthefollowingstatementsistrueorfalse.（10×

2points=20）

1.Ahaptencanstimulateantibodyformationbutcannotcombinewithantibodymolecules.（F）

2.Boostershotsarerequiredbecauserepeatedexposuretoanantigenbuildsastrongerimmuneresponse.（T）

3.TheIgα/IgβheterodimerandCD3serveanalogousfunctionsintheB-cellreceptorandT-cellreceptor,respectively.（T）

4.Antigen-presentingcellsexpressbothclassIandclassIIMHCmoleculesontheirmembranes.（T）

5.BabiescanacquireIgE-mediatedallergiesbypassivetransferofmaternalantibody.（F）

6.BothCTLsandNKcellsreleaseperforinafterinteractingwithtargetcells.（T）

7.Targetcelllysisanddestructioncanbeachievedbyperforinreleasedfromantigen-specificcytotoxicT-cells（T）

8.Theimmuneresponseismediatedviathehumoraland/orcellulararmsoftheimmunesystem（T）

9.ImmediatetypehypersensitivityismediatedbyIgM.（F）

10.Allcytokine-bindingreceptorscintaintwoorthreesubunits.（T）

ⅢAnswerthefollowingquestionsinbrief（10×

4points=40）

1.NamethethreetypesofprofessionalAPCs,andgiveoneexampleofnonprofessionalAPCs.BMDCendothelialcell

2.Summarizethefourmajorfunctionsofcomplementsystem①lysisofcells,bacteriaandviruses②opsonizationtoenhancephagocytosis③clearanceofimmunecomplexes④stimulationofinflammation

3.ListtheclassicalClassIandClassIIgenelociforhumans

4.Whatdose"

MHCrestriction"

mean?

HLA-A,B,CHLA-DPDRDQ

5.ToactivateTcells,twomoleculesmustberecognizedontheantigen-presentingcells,whatarethey?

Peptide-MHC

6.Comparetheprimaryandsecondaryresponsesfromthefollowingpointsofview:

（a）timeforantibodytoappear（b）quantityofantibodyproduced（c）classofantibodyproduced（d）durationofantibodyproduction.

7.CompareClassIandClassIIMHCproteinsfromthefollowingpointsofview:

（a）typesofcellsonwhichtheyarelocated（b）roleinantigenrecognitionbyCD4+andCD8+Tcells.

8.HelperTcellscanbedividedintotwosubsetsbasedontheirlymphokinesecretionprofile.Explain.

9.Whatarethemainfunctionsofmacrophages?

10.PleasedrawaschematicdiagramofatypicalIgGmoleculeandlabeleachpartofthechains.

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