药剂学习题与答案Word格式.docx

药剂学习题与答案Word格式.docx

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c.E

d.B

e.D

Chapter2DesignofDosageForms

1.1Singlechoice

1.D

2.A

3.B

1.2Multiplechoices

1.ABCDE

2.ABC

3.ABCDE

4.ABCD

Chapter3Stabilityofdosageforms

1.A

4.D

6.B

7.C

8.E

9.A

10.C

11.B

1.ABD

2.ABCDE

3.CDE

4.CE

5.DE

.Answer

1.WhichitemsaregenerallyincludedinNewDrugResearchstabilitytest?

（1）effectfactorexperiments,includinghigh-temperaturetest,high-humiditytest,strong-lighttest

（2）accelerationexperiments

（3）Long-termexperiments

2.Whichfactorsaffectthestabilityofpharmaceuticalpreparations?

（1）prescriptionfactors:

①pHvalue;

②generalacid-basecatalysis;

③solvent;

④ionicstrength;

⑤surfactant;

⑥matrixorexcipientinprescription.

（2）externalfactors:

①temperature;

②light;

③air（oxygen）;

④metalions;

⑤humidityandwatercontent;

⑥packagingmaterial.

3.Pleasewritethereactionrateequationofzero-orderandfirst-orderreaction,aswellasthecorrespondinghalf-lifeandvalidperiod.

reactionrateequationhalf-lifevalidperiod

zero-orderC=-kt+C0C0/2kC0/10k

first-orderlgC=-kt/2.303+lgC00.693/k0.1054/k

4.PleasewritetheArrheniusequation,andclarifythemeaningofeachparameter.

Arrheniusequation:

lgk=-E/2.303RT+lgA

Intheformula,kisreactionrateconstant,Eisactivationenergy,Risgasconstant,Tisabsolutetemperature,Aisfrequencyfactor.

.Calculation

1.Acetylsulfanilamidesodiumat120℃andpH7.4withfirstreactionrateconstantof9×

10-6s-1,activationenergyof95.72kJ/mol,howaboutthevalidperiod?

lgk=-E/2.303RT+lgA

lgk25=-E/2.303RT25+（lgk120+E/2.303RT120）

=lgk120+E/2.303R（1/T120-1/T25）

=lg9×

10-6+95.72*1000/2.303*8.314（1/393-1/298）

=-9.100

K25=7.9256*10-10

t0.9=0.1054/k

=4.21years

2.Ara-CsolutionpH6.9,at60℃,70℃,80℃threeconstanttemperaturewaterbathtocarryouttheacceleratedtest,respectivelyobtainedthefirstrateconstantwas3.50×

10-4h-1,7.97×

10-4h-1,1.84×

10-3h-1,howabouttheactivationenergyandvalidperiod?

T

k

1/T

lgk

333

0.00035

0.003003

-3.4559

343

0.000797

0.002915

-3.0985

353

0.00184

0.002833

-2.7352

Thelinearregressionequationoflgkon1/Twas：

lgk=-4237.2（1/T）+9.2635

k25=1.1084×

10-5h-1

E=81130.27

t0.9=0.1054/k=9.5089×

103h=396.2days=13.2months

3.Ampicillinsodiumat45℃tocarryouttheacceleratedtest,obtainedt0.9=113d,iftheactivationenergyis83.6kJ/mol,howaboutthevalidperiodofampicillinsodiumat25℃?

k45=0.1054/t0.9=0.1054/113=0.0009327d-1

lgk25=-E/2.303RT25+（lgk45+E/2.303RT45）

=lgk45+E/2.303R（1/T45-1/T25）

=lg0.0009327+83.6*1000/2.303*8.314（1/318-1/298）

=-3.9517

K25=1.1175×

10-4d-1

=943.1598days=2.59years

Chapter4Surfactants

.True/FalseQuestions

1.F

2.F

.BlankFillingQuestions

1.___9___.

2._cationicsurfactant,_anionicsurfactant,andamphoteric/amphiphilic/zwitterionicsurfactant.

.SingleChoiceQuestions

1.__B___

2._A_____

3._A_____

4.D

.MultipleChoiceQuestions

Chapter5RheologyandMicromeritics

I.Choice

1.D

2.C

3.C

5.B

6.D

7.C

8.C

1.2Multiplechoices

1.ABC

2.AD

3.AC

4.AC

5.ABCD

6.AC

7.AC

.GapFilling

1.Thefollowingwingfiguresdescribetherheologicalpropertiesofdifferentfluids,pleasefillintheirnames．

2.（Newtonian-fluid）and（non-Newtonian-fluid）.（plasticflow）,（pseudoplasticflow）and（dilatantflow）.

Chapter7~8Liquiddosageformsandinjection

1.T

2.T

3.T

4.F

5.T

6.F

IIBlankFillingQuestions

1.commonion

2.polarity

3.（solubilizer）,（hydrotropyagent）,（cosolvent）,（preservative（aseptic））,（flavoringagent）and（colorant）.

4.（ethanol）,（propyleneglycol）,and（polyethyleneglycol）.

5.（hotdissolutionmethod）and（colddissolutionmethod）.

6.（swelling）and（dissolution）.

7.（thetypeandquantityofmicroorganisms）,（steamproperties）,（drugproperties）and（sterilizationtime）.

8.（0.22µ

m）

9.（lamina）

10.（filtration）,（electrodialysis）,（ionexchangeprocess）and（distillation）.

Ⅲ.Single-choice

1.B

5.B

6.A

7.A

8.D

10.D

11.D

12.D

13.A

14.B

15.A

16.D

17.D

18.C

19.A

20.A

21.D

22.A

23.A

24.B

25.D

26.E

27.C

28.B

29.A

30.A

31.A

32.C

33.A

.Multiplechoices

1.BCD

2.BD

3.ABDE

4.ABCD

6.ABE

7.BCD

8.ACE

9.ABCDE

10.ABCE

11.ABCDE