贺勇fMRI研究设计和论文写作PPT文件格式下载.ppt

贺勇fMRI研究设计和论文写作PPT文件格式下载.ppt

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“Thisisaninterestingwell-writtenandcreativelyconceivedpapershowingforthefirsttimethathumanbrainanatomicalconnectivitymaybetopologicallyorganizedaccordingtosmallworldprinciples.”Reviewer2:

“Thispaperdealswithanimportantandverysignificantresearcharea,thecharacterizationoftheanatomicalnetworkoflong-rangeconnectionsinthehumanbrain.Thiscrucialdatasetiscurrentlylackingandanyprogresstowardsamorecompleteanatomicaldescriptionofthehumancortexishighlydesirable.Thepaperattemptstoaddressthisissuebyusinganovelandpotentiallyinterestingapproachtowardsmappinganatomicalpathwaysandprovidesananalysisoftheresultingnetwork.”StructuralMRI-basedBrainConnectomeAnalysisMethods（Chenetal.,CerebCortex2009;

Sanabria-Diazetal.,NeuroImage2010）Normaldevelopment（Fanetal.,NeuroImage2011）Normalaging（Wuetal.,HumBrainMapp2011;

Zhuetal.,NeurobiologyofAging2011;

Chenetal.,NeuroImage2011）Alzheimersdisease（Heetal.,JNeurosci2008;

Yaoetal.,PLoSComputationalBiology2010）Multiplesclerosis（Heetal.,Brain2009）Epilepsy（Rajetal.,NeuroImage2010;

Bernhardtetal.,CerebralCortex2011）Schizophrenia（Bassettetal.,JNeurosci2008）Genetic（Schmittetal.,CerebralCortex2009）Howtoformtheidea?

2003年IPMI2003:

reject2003年2subjectsfromDr.XuchuWengIPMI2003:

rejectSmall-worldhumanbrainfunctionalnetworksbyresting-statefMRISalvadoretal（2005）CerebCortex2005.7.20MeetingwithAlanEvansandKeithWorsley说服你的老板！

MontrealLerchetal（2006）NeuroImage2005.09Question:

canweusestructuralMRItoconstructbrainnetworks?

Hypothesis:

humanbrainstructuralnetworkshaveasmall-worldorganization.Workhard!

Remember:

youonlyhaveonechance!

RegionsRegionsNetworkconstructionCorticalthicknessmeasurements0.60.40.20-0.2-0.4RegionsCorticalparcellation（ANIMAL+INSECT）Cross-correlationmatrixFDRHumancorticalthicknessnetworkBinarizedmatrix12407Subjects54CorticalthicknessdatamatrixHeetal（2007）CerebCortexMethodsParticipants/experimentaldesign/MRI（ICBM152）ImagingprocessingStatisticalanalysis要求：

合理性/准确性/新颖性/完整性方法描述必须准确，逻辑清晰关键的方法简要描述其合理性尽量避免任意选择参数，否则要评价参数变化对结果的稳定性充分利用你的data引述公式和采用别人的方法必须给出出处整个部分具有完整性Methods要求：

方法描述必须准确，逻辑清晰ThenativeMRimageswerefirstregisteredintostereotaxicspace（TalairachandTournoux1988）usinga9-parameterlineartransformation（Collinsetal.1994）.Simultaneously,imageswerecorrectedfornonuniformityartifactsusingtheN3algorithms（Sledetal.1998）.Theregisteredandcorrectedimageswerefurthersegmentedintograymatter,whitematter,cerebrospinalfluid,andbackgroundusinganadvancedneuralnetclassifier（Zijdenbosetal.2002）.TheinnerandoutergraymattersurfaceswerethenautomaticallyextractedfromeachMRvolumeusingtheConstrainedLaplacian-basedAutomatedSegmentationwithProximities（CLASP）algorithm（MacDonaldetal.2000;

Kimetal.2005）andcorticalthicknesswasmeasuredinnativespaceusingthelinkeddistancebetween2surfacesat40962verticesthroughoutthecortex.Methods要求：

方法描述必须准确，逻辑清晰Finally,temporalfiltering（0.01Hzf0.08Hz）wasperformedonthetimeseriesofeachvoxeltoreduce（notavoid!

）theeffectoflow-frequencydriftsandhighfrequencynoise（Biswaletal.,1995;

Loweetal.,1998;

Jiangetal.,2004）.Methods要求：

方法描述必须准确，逻辑清晰关键的方法简要描述其合理性TheCLASPcorticalthicknessalgorithmhasbeenvalidatedusingbothmanualmeasurements（Kabanietal.2001）andsimulationapproaches（LerchandEvans2005;

Leeetal.2006）,andrecentlyappliedtoAlzheimersdisease（Lerchetal.2005）andcorticaldevelopmentstudies（Shawetal.2006）.Methods要求：

方法描述必须准确，逻辑清晰关键的方法简要描述其合理性尽量避免任意选择参数，否则要评价参数变化对结果的稳定性Toexploretheinfluenceofthresholdingonthesmall-worldattributes,inthisstudy,weappliedthemaximumrangeofcorrelationthresholds（0RRmax,withanincrementalintervalof0.01）tothecorrelationmatrix,andrepeatedthesmall-worldanalysisforeveryRvalue.Methods要求：

方法描述必须准确，逻辑清晰关键的方法简要描述其合理性尽量避免任意选择参数，否则要评价参数变化对结果的稳定性充分利用你的data引述公式和采用别人的方法必须给出出处整个部分具有完整性Results通常分标题进行要求：

逻辑清晰，主次分明（避免简单重复）注意所投期刊的风格：

是否需要简单讨论合理使用SupplementalMaterialsCorpuscallosumShort-distancefibersSuperiorlongitudinalfasciculusThemostsignificant15corticalthicknesscorrelationsAABC（CorrectedPCpbrainCprandomLpr