橘 皮Orange peel.docx

橘 皮Orange peel.docx

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橘皮Orangepeel

橘皮（Orangepeel）

Orangepeel

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RutaceaecitrusCitrustangerinaHort.etTanakaC.erythrosaTanakaorcumquatandothercitruspeel.Acrid,bitterandwarminnature.Inspleenandlung.Function:

reason

Gas,transfer,dampness,phlegm.Indications:

abdominaldistension,poorappetite,vomiting,hiccup,coughandphlegm.Fishandcrabpoison,too.Oraladministration:

decoction,3~9g;orintothepill,scattered.

[modernresearch]

Mainingredients:

driedtangerinepeelcontainsvolatileoil1.9%~3.5%.Mainlyforthelimonene（Limonene）;therearealphathujene（alpha-Thujene）,alphapinene（alpha-Pinene）,betapinene（betaPinene）,betamyrcene（Beta

Myrcene（Sabine-NE）,sabinene）,octylaldehyde（Octanal）,alphaphellandrene（-Phellandrenealpha）,alphaTerpinene（alpha-Terpinene）,ellagicacid（p-Cymene）-thyrse,linalool（Linalool）,musk

Vanillaphenol（Thymol）,citronellaaldehyde（Citronellal）andothercomponents.

Inaddition,hesperidin（Hesperidin）,newhesperidin（Neohesperidin）,citrus（Tangeretin）,flavonoids,citral,beta-glutamyl（beta-Sitosterol）,andQiangFulin

（Synephrine）etal.

Pharmacologicalaction:

1.expectorantandantiasthmaticeffect,thevolatileoilcontainedinPericarpiumCitricitriisirritatingexpectoranteffect,themainingredientislimonene.ThefreshproductDecoctionseemstohavebronchiectasis.Tangerinepeel0.02gextract（crudedrug）/mlconcentration,can

Convulsivecontractionofguineapigisolatedfromguineapigscompletelyagainsthistamine.Ithascertaincurativeeffectonbronchialasthma.Theanimalexperimentshowedthatnobiletinintravenously,abronchodilator,strengthwaslessthanthatofammonia

Theophylline,butintravenousinjection,enema,andintragastricadministrationcannotcombatbronchospasmcausedbyhistamine.Theeffectofmethylhesperidinontheisolatedtracheaofguineapigsisverysmall.

2.theeffectsofthedecoctionofPericarpiumCitricitri,ethanolicextractandhesperidinontheheartofisolatedandinvivofrogswerestimulated.Intravenousinjectionofhesperidincanincreasethecontractilityandcardiacoutputintherabbits

Add,butnosignificanteffectonheartrate.Hesperidincontainingoxidationproductscanincreaseheartcontractilityandheartrateinrabbits,whilepureproductsarenoteffective.Methylorangehesperidin40mg/kgwasgivenintravenouslyindogstoreducecoronaryresistanceandincreasecrownsize

Theeffectofpulseflow,loweringbloodpressureandslowingheartrate,butnosignificantinfluenceonmyocardialoxygenconsumption,myocardialoxygenutilizationrateandmyocardialcontractility.

Theintravenousinjectionofdriedtangerinepeelcanincreasethebloodpressureofrabbitsanddogsrapidly.Repeateduseofmedicinedoesnotproducerapidtolerance.Itcanalsoreducethevolumeofcaninekidney,vasoconstrictionofrenalvesselsanddecreaseofurinevolume.Theboostingingredientsofdriedtangerinepeel

Boilingisnotdestroyed,theactiontimeislongerthantheadrenaline,andmorestable.Hesperidinhasnohypotensiveeffectonanesthetizedcatsanddogs,andevenantagonizedthevascularcontractioninducedbyadrenalineperfusioninrabbitears.Theeffectofhesperidinontheperipheralbloodofcats

Tubeshaveshortandobviousexpansion,butpureproductswithoutoxidesareineffective.

PPhesperidinhastheeffectofdecreasingserumcholesterolandreducingandimprovingthemainatheroscleroticlesioninrabbitswithexperimentalhyperlipemia.

Orangepeelpowderformiceandrabbitsbygavage,shortenthebleedingtimeandclottingtimeeffect,bakedintocharcoalpowdermedicinetoshortenthecoagulationtimeeffectofcrudedrughasbeenenhanced.

3.theeffectofthedecoctionofdriedtangerinepeelonthemovementofthesmallintestineinmiceandrabbitswasinhibitedbyintravenousinjection,andthegastricmotilityofanesthetizeddogs,gastrointestinalandanesthetizedrabbitsandanesthetizedrabbitswasalsoinhibitedbyintravenousinjection.Thiseffectisgreater

Epinephrineisweakbutpersistent.Theexperimentprovedthatthedriedtangerinepeelhastheactionofresistingacetylcholinetotherabbitintestine,buttheeffectofthetangerinepeeloninhibitingtherabbitintestinecanbealsoaffectedbyacetylcholine.Orangepeelisalsoreferredtopilocarpineorbariumchloride

Thespasticcontractionoftheintestinaltracthasanantagonisticeffect.

Itissuggestedthatthedirectinhibitionofsmoothmuscleofintestinebytangerinepeelisitsmainwayofrelievingspasm.

Methylhesperidin0.5to1mg/mlcouldcompletelyinhibitthemovementofisolatedileuminguineapigs,butonlyslightspasmofintestinalmusclespasmcausedbyacetylcholine,histamineorbariumchloride.Italsoinhibitedthera