Heck 反应060206.docx

1、Heck 反应060206经典化学合成反应标准操作Heck 反应编者： 何大荣药明康德新药开发有限公司化学合成部目 录1. 前言 22. 分子内的Heck反应 32.1 生成烯基取代的反应 32.1.1 分子内Heck反应化生成环外双键示例 42.2 形成季碳中心的反应 52.2.1 分子内不对称Heck反应示例 62.3 多烯大环的合成 62.2.1 Heck反应用于合成大环多烯示例 73. 分子间的Heck 反应 83.1 常规分子间Heck反应 83.1.1 Pd(OAc)2-P(o-tol)3体系用于不饱和羧酸酯的Heck反应标准操作三 93.1.2 不饱和酮的Heck反应标准操作 1

2、03.1.3 杂环芳香卤代物和不饱和羧酸酯的Heck反应标准操作一 103.1.4 杂环芳香卤代物和不饱和羧酸酯的Heck反应标准操作二 103.1.5 芳香卤代物和不饱和羧酸的Heck反应合成反式3-芳基不饱和酸示例 113.1.6 非共轭双键Heck反应示例 113.2 不对称分子间Heck反应 123.3 非常用离去基团的Heck反应（Irina P. Beletskaya Chem. Rev. 2000, 100, 3009-3066） 123.3.1 重氮盐参与的Heck反应示例 133.3.2 酰氯参与的Heck反应示例 151. 前言通常把在碱性条件下钯催化的芳基或乙烯基卤代物和

3、活性烯烃之间的偶联反应称为Heck反应。自从20世纪60年代末Heck 和Morizoki独立发现该反应以来,通过对催化剂和反应条件的不断改进使其的应用范围越来越广泛,使该反应已经成为构成C-C键的重要反应之一。另外，Heck反应具有很好的Trans选择性研究表明，Heck反应的机理有一定的规律，通常认为反应共分四步：（a）氧化加成（Oxidative addition）: RX (R为烯基或芳基，X=I TfO Br Cl)与Pd0L2的加成，形成Pd配合物中间体；（b）配位插入 （Cordination-insertion）:烯键插入Pd-R键的过程； （c）-H的消除； （d）催化剂的再

4、生：加碱催化使重新得到Pd0L2。总的说来，Heck反应可以分为两大类：分子内反应和分子间反应。第一篇该反应的报道是Heck 在1972年发表。Nolley, J.P.; Heck, R. F.; Tetrahedron 1972, 37, 2320Mori 和 Ban于1977年首次报道了分子内的Heck反应：Mori, M.; Ban, K.; Tetrahedron 1977, 12, 1037经过三十多年的发展，Heck反应的应用也越来越广泛。每一类反应根据其特点的不同由可以分成几类。2. 分子内的Heck反应2.1 生成烯基取代的反应该类反应主要用于生成环外双键。环外双键是合成上一大

5、难题，该反应成功的应用具有重大意义。目前已有合成的报道。Danishefsky, S. J. J. Am. Chem. Soc. 1993, 115, 6094该反应还被Danishefsky应用到全合成Taxol上。Danishefsky, S. J. J. Am. Chem. Soc. 1996, 118, 28432.1.1 分子内Heck反应化生成环外双键示例A stirred solution of 1 (98 mg, 0.19 mmol), triethylmine (0.32 mL, 2.3 mmol) and catalytic tetrakis(triphenylphosph

6、ine)palladium(0) (ca. 5 mg, 4 mol) in 2.4 mL of acetonitrile was heated at 80 in a sealed tube under an argon atmosphere for 10 h. The reaction mixture turned dark orange after ca. 10 min, and the catalyst plated out on the walls of the tube as a shiny layer of palladium metal upon completion of the

7、 reaction. The reaction mixture was cooled to room temperature; the reaction was quenched with aqueous NaHCO3(15 mL), and the mixture was extracted with EtOAc (410 mL). The organic extracts were washed with aqueous NaHSO3 (115 mL), water (115 mL), and brine (115 mL) and dried over MgSO4. Filtration,

8、 concentration, and purification of the orange residue by flash column chromatography (45:55 Et2O/hexanes) gave 66 mg (90%) of 19 as a colorless solid: mp 193-194 ; Rf = 0.29 (8:2 Et2O/hexanes).2.2 形成季碳中心的反应从20世纪80年代早期研究以来得到了广泛的应用。1989年，Shibasaki 和Overman 首先报道不对称Heck反应。J.Org.Chem. 1989, 54, 4738同一年，

9、Overman及其工作组首先利用Heck 反应合成了手性季碳原子。J.Org.Chem.1989,54,5846 像天然产物physostigmine的合成，成功的运用和Heck反应构成手性的季碳中心。Matsuura, T.; Overman, L.E. J.Am.Chem.Soc. 1998, 120, 65002.2.1 分子内不对称Heck反应示例A mixture of Pd2(dba)3CHCl3 (360 mg, 0.347 mol), (s)-BINAP (504 mg, 0.809 mol), and N,N-dimethylacetamide (DMA, 21 mL) wa

10、s stirred at room temperature for 65 min. To the resulting orange solution was added a solution of compound 1 (1.82 g, 3.51 mol), 1,2,2,6,6-pentamethylpiperidine (3.2 mL, 18 mmol), and DMA (18 mL), and the reaction was heated at 100 for 90 min. The result dark solution was poured into half-saturated

11、 aqueous NaHCO3 (100 mL) and extracted with ether (3 150 mL). The combined organic extracts were washed with brine (100 mL), dried (MgSO4), and concentrated, and the residue was purified by sgc (9:1 1:1 hexane-EtOAc) to give oxindole enoxysilane compound 2 (1.29 g, 94%) as a 98:2 mixture of geometri

12、c isomers: 25D 81o (c 0.61 C6H6).2.3 多烯大环的合成分子内Heck 反应形成的多烯大环化合物(大于13)。Zeigler 就利用Heck反应成功合成十六元环的大环多烯化合物。Zeigler, F. Tetrahedron, 1981, 37, 4035也有多烯经过多次分子内Heck反应，一步构建多个碳碳键和多元环。Overman 就成功应用Heck反应一步构建了二个环和二个季碳中心。Overman, L.E. J.Am.Chem.Soc., 1999,121,54672.2.1 Heck反应用于合成大环多烯示例A solution of vinyl iodi

13、de 1 (740 mg, 1.35 mmol) and THF (75 mL) was degassed (Ar, evacuate-refill), and Ph3P (107 mg, 0.41 mmol), Ag2CO3 (410 mg, 1.5 mmol), and Pd(OAc)2 (46 mg, 0.20 mmol) were added. The resulting suspension was stirred at room temperature for 15 min and then heated at 65 in a sealed tube for 12 h. A bla

14、ck suspension resulted after 10-20 min at 65 . After GC analysis of a filtered aliquot showed that the reaction had not proceeded to completion, additional Ph3P (107 mg, 0.41 mmol), Ag2CO3 (410 mg, 1.5 mmol), and Pd(OAc)2 (46 mg, 0.20 mmol) were added, and the black suspension was stirred in a seale

15、d tube at 65 for an additional 6 h. The suspension was then cooled to room temperature and filtered through a plug of silica gel (1.5 cm12 cm, EtOAc), and the filtrate was concentrated to give the crude Heck product as a yellow oil. This sample was dissolved in THF (4 mL), and TBAF (1.0 M solution i

16、n THF, 2.0 mL) was added. The resulting solution was maintained at room temperature for 20 h and quenched with saturated aqueous NH4Cl (20 mL). The resulting mixture was extracted with CH2Cl2 (320 mL), the combined organic layers were dried (NaSO4), filtered and concentrated, and the residue was pur

17、ified by flash chromatography (4:1 hexanes-EtOAc) to provide 370 mg (90%) of tricyclic allylic alcohol 2 as a pale yellow oil: Rf=0.25 (5:1 hexanes-EtOAc).3. 分子间的Heck 反应3.1 常规分子间Heck反应端基烯烃与卤代芳香烃发生分子间Heck反应，是研究最早的一类反应。这类反应已经成为芳烃烷基化重要反应。该类反应在卤代物中，卤素的位的碳原子上不能有SP3杂化的氢原子。主要是因为这类卤代物形成烷基钯络合物时，氢化钯的消除反应速度大于烯

18、烃的加成反应，因此仅有消除产物。卤代芳烃、卤代杂环、卤化苄、卤代乙烯等都能较好的反应。但其他一些卤素的位的碳原子上没有SP3杂化的氢原子存在的化合物由于种种原因也不能正常反应，例如：卤代甲烷、卤代乙酸乙酯、苯甲酰甲基溴等。该类反应常用碘代物和溴代物为反应底物，碘代物相对溴代物反应活性要高。氯代物反应活性很差（几乎不反应或者收率很低）。在取代碘代物参与的反应中，取代基可以很广泛的使用，但邻位的苯甲酰基取代碘化物很难反应。当有强烈供电子基团时，芳基溴参与的反应收率也很低。其主要原因是在反应中膦配体被季化与卤代物被还原。当使用P(o-tol)3作为配体时，可以有效的避免配体的季化。另外，当有强烈的供

19、电子基团时，烯烃的活性也很重要。低活性烯烃参与的反应收率也较低。决定烯烃活性的主要因素是烯烃双键碳原子取代基的大小和数目。一般情况下，取代基越大，数目越多，反应速度越小，收率越低。当一些烯烃反应活性较差时，通常可以得到卤化物二聚的副产物。一般说来，共轭二烯和, -不饱和羰基化合物的活性高于立体相似的单烯化合物。例如卤代烯烃与丙烯酸的反应速度远大于丙烯腈，而丙烯腈的活性又高于丙烯缩醛。在大多数情况下，Pd-H的消除符合Curtin-Hammett动力学控制规则，即过渡态的能量反应了顺反异构体的比例。一般情况下，除非R特别小（如 CN）,反式异构体是主要产物，（见下例）。其选择性甚至超过Witti

20、g-Horner反应。但由于存在异构化，热力学控制时常常产生二者的混合物，从而导致例外的情况出现。而烯丙基醇与卤代化合物发生分子间Heck反应，通过一系列消去-加成过渡态，可以得到羰基化合物。目前，我们应用该反应最多的是芳基卤代物和, -不饱和羰基化合物之间的偶联反应，通过催化剂、配体的选择及反应条件的优化，一般都能以合适的收率得到Trans偶联产物。3.1.1 Pd(OAc)2-P(o-tol)3体系用于不饱和羧酸酯的Heck反应标准操作三A mixture of 3-bromoquinoline (2.08 g, 10.0 mmol), methyl acrylate (1.08 g, 1

21、2.5 mmol), palladium acetate (23.6 mg, 0.1 mmol), tri(o-tolyl)phosphine (0.122 g, 0.4 mmol) and triethylamine (3.62 g, 35.8 mmol) was heated under argon in a heavy-walled Pyrex tube at 100.deg. C. for 6 h. The cooled reaction mixture was diluted with DCM (60 ML) and distilled water (30 ML).The organ

22、ic layer was washed with distilled water (3*25 ML).The aqueous layer was extracted with DCM (25 ML).The combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to give a pale yellow solid.Purification by recrystallization with EtOAc and hexanes gave an off-whit

23、e crystalline solid (1.82 g; 85percent):3.1.2 不饱和酮的Heck反应标准操作A mixture of 4-bromotoluene (10.0 mmol), Cyclohex-2-enone (10 mmol), palladium acetate (0.1 -0.5 mmol), tri(o-tolyl) (0.2-1 mmol, 催化剂的2-4倍的量) and DIEA (30 mmol) in DMF (30 mL) was heated under N2 at 100 oC for 6-12 h. The reaction mixture

24、was cooled, diluted with 50 mL of water and extracted with ether (2 x 50 mL). The combined organic portion was washed with brine solution, dried over anhydrous magnesium sulfate and finally filtered. Evaporatation of the volatiles under reduced pressure purification with column chromatography to giv

25、e the product.Note: 有时可以分离到双键还原的产物。3.1.3 杂环芳香卤代物和不饱和羧酸酯的Heck反应标准操作一A suspension of ArBr (68.4 mmol), Pd(dppf)Cl2 (5 g, 6.84 mmol), tetrabutylammonium iodide (30 g, 82 mmol) and K2CO3 (28 g, 205 mmol) in N,N-dimethylformide (130 mL) was degassed via three vacuum/nitrogen ingress cycle, and then added

26、 methyl acrylate (17.6 g, 205 mmol), the mixture was stirred at 100 oC overnight. To the mixture was added water; the aqueous layer was extracted with Et2O (3100 ml). The combined organic phases were washed by brine, dried over MgSO4, filtered and concentrated. The residue was purified by column chr

27、omatography to afford the product (, yield50%).3.1.4 杂环芳香卤代物和不饱和羧酸酯的Heck反应标准操作二A suspension of ArBr (170mmol), Pd(OAc)2 (1.9g, 8.5mmol), tetrabutylammonium iodide (55.0g, 170mmol) and KOAc (5.01g, 511mmol) in N,N-dimethylformide (200 mL) was degassed via three vacuum/nitrogen ingress cycle, and then

28、 added methyl acrylate (46.0mL, 511mmol), the mixture was stirred at 100 oC overnight. To the mixture was added water; the aqueous layer was extracted with Et2O (3300 mL). The combined organic phases were washed by brine, dried over MgSO4, filtered and concentrated. The residue was purified by colum

29、n chromatography to afford the product (15 g, yield 50%). Note: Pd(OAc)2的质量有时是实验成败的关键。3.1.5 芳香卤代物和不饱和羧酸的Heck反应合成反式3-芳基不饱和酸示例A solution of compound 1 (2.8 g, 10 mmol), compound 2 (0.9 mL, 12.5 mmol), Pd(OAc)2 (0.022g, 0.01 mmol), Et3N (3.5 mL, 25 mmol) and 4 mL acetonitrile was heated in a steam bath

30、 for 1 hour. After the reaction mixture had been cooled, it was diluted with 250 mL 10% aq. HCl. The solid formed was collected by filtration and re-crystallized from ethanol to give compound 3 (1.86 g, yield 82%), mp 215-216.5.3.1.6 非共轭双键Heck反应示例Typical procedure for the preparation of cinnamaldehy

31、de:To a stirred solution of p-iodoanisole (0.117 g, 0.5 mmol) in 2.0 mL of DMF were added acrolein diethyl acetal (0.229 mL, 1.5 mmol), nBu4NOAc (0.302 g, 1.0 mmol0, K2CO3 (0.104 g, 0.75 mmol), KCl (0.037 g, 0.5 mmol), and Pd(OAc)2 (0.003 g, 0.015 mmol). The mixture was stirred for 1.5 h at 90oC. Af

32、ter cooling, 2 N HCl was slowly added and the reaction mixture was stirred ar room temperature for 10 min. Then, it was diluted with ether and washed with water. The organic layer was dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by chromatography (silica gel, 35 g; n-hexane/ethylacetate 90/10 v/v) to give 0.071 g (88%) of p-methoxycinnamaldehyde.3.2 不对称分子间Heck反应1992