张天佑教授简历1.docx

1、张天佑教授简历1张天佑教授简历1960-1963 中国科技大学授课教师1977- 北京市新技术应用研究所总工程师,学术委员会主任1987- 美国国立健康研究院客座研究员 创建了高速逆流色谱技术在天然产物活性化合物分离纯化方面的应用技术基础工作。获得美国发明专利。1989- 北京市科学技术研究院生化分离检测技术重点实验室主任1990-1991 美国北卡州大学客座教授 指导研究生蛋白质分离纯化的研究。1991-1994 北京科技研究院旧金山办事处主任1991- 美国加州基因实验科技有限公司客座研究员,科技顾问1995- 国家中药制药工程技术研究中心现代分离纯化技术实 验室主任开创了高速逆流色谱技术

2、纯化和制备中草药活性成分标准物质的研发工作，成为国家工程中心“十五”期间的重大科技成果。1998- 北京天然产物分离纯化技术研究中心首席专家创建了天然药物、农产品、海洋生物中活性化合物的高速逆流色谱分离制备方法，推广应用于相关科技与产业领域。成果在浙江由中国农业科学院茶叶研究所（杭州）、浙江大学、娃哈哈集团研究所引用。并因推进宁波市北仑经济开发区高科技产业，曾获宁波市特殊贡献专家奖励。2000- 国际逆流色谱技术学术委员会核心成员 2002年第二届国际逆流色谱技术学术会议主席。 香港生物科技研究院高级顾问研制成功丹参、三七中的七种高纯度单体对照品。2004- 全国标准样品技术委员会天然产物标样

3、专业工作组常 务副组长研发成功天然产物类活性化合物高纯度国家实物标准样品四十余项，已通过国际标准化组织（ISO）向国际公布。从2005年起，作为中国代表团成员参加ISO/REMCO年会，建立了国际合作。 2006- 中国保健协会行业标准化工作委员会副主任，兼任 技术 标准审定专家组组长。已建立银杏提取物、石斛提取物、大豆异黄酮等十余项行业标准。2007- 中关村科技园大兴国家生物工程与医药产业基地、 药谷一 号国际医药产业研发孵化园首席专家已建立以任德权教授、罗国安教授、屠鹏飞教授、杨世林教授、张卫东教授、王智明教授等专家为核心的技术团队，并建立了同清华大学、北京大学、中国药科大学、中国医学科

4、学院药用植物研究所、第二军医大学、江西中医学院等重点实验室的合作。2008- 国际中医药联合会标准化委员会委员2009- 广东省中药和天然产物对照品研究中心主任、首席专家 目前在中科院姚新生院士、 国家药监局副局长任德权教授、等专家的参与支持下，已建成中药及天然产物对照品（标准品）研究开发技术平台和天然产物对照品库（现有500余种高纯度对照品，三年内扩展为3000种），在国内不同资源地（北京、上海、乌鲁木齐、西安、开封、厦门、广州）建立了8个联合实验室，并且这些实验室已同国际标准化合作组织（ISO）、美国药典委员会（USP）、欧洲标准中心、巴西标准中心等国际组织建立合作关系。主要科技成果及获奖

5、情况:1， 获美国发明专利1项 （US Patent:No.7 488,464(1991)）。 中国发明专利14项。中国仪器实用新型专利12项2 1991年起获国务院自然科学技术领域特殊贡献专家奖3 获国家级、省部市级科技奖二十余项4 已在国际专业领域合作发表英文专著六部（如： High-Speed Countercurrent Chromatography, Vol. 132 in Chem.Anal: A Series of Monographs on Anal. Chem. and its Appli., New York, John Wiley & Sons(1996) (Monogr

6、aph); Comprehensive Analytical Chemistry, Vol.XXXVIII. Countercurrent chromatography-the support free liquid stationary phase. ELSEVIER, (2002),(Monograph)等）.5, 已发表中文专著六部（如；逆流色谱技术，北京科技出版社，1990；制备分离技术，科学出版社，2000；等）6 作为编委会主任主持编著中国化工出版社出版的现代分离科学与技术丛书（14卷册，500万字），现已出版发行丛书中的5册。7 在国际上发表英文论文二百余篇 在国内发表论文二百余

7、篇8 1984后的一部分天然产物活性化合物分离纯化方面的英文论著其他任职：1. 清华大学、北京大学、北京理工大学、中国农业大学、中国药科大学、西北大学、上海中医药大学等十多所大学院校兼职教授，校外博导。2. 6个中央科研院所的客座研究员、博士生导师。,3. 中国生物医药技术协会中国生物制药技术分会副理事长。4. 中华医学会抗衰老与脑痴呆委员会等学术团体理事。5. 、 等6种国际（英文）科技刊物论文审评专家。6. 北京朝阳抗衰老生命科学研究所副所长7. 、等4种中文杂志编委8. 中国仪器仪表学会,分析仪器学会9. 中华炎黄文化研究会顾问。1984后的一部分天然产物活性化合物分离纯化方面的英文论著

8、1. T. Y. Zhang, A Horizontal Flow Through Coil Planet Centrifuge for Counter-current Chromatography. Abstracts of the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy. No. 476(1984).2. T. Y. Zhang, Horizontal Coil Planet Centrifuge Chromatography: Some Practical Applications of

9、 Countercurrent Chromatography. Journal of Chromatography, 315(1984), 287-297.3. 3 , et al, Separation of Flavonoids in Crude Extract From Sea Buckthorn 4. by Countercurrent Chromatography with Two Types of Coil Planet Centrifuge. 5. Journal of Liquid Chromatography,11(1),(1988).233-244.6. T. Y. Zha

10、ng, et al, Separation of Flavonoids and Alkaloids in Medicinal Herbs by High Speed Countercurrent Chromatography. Journal of Chromatography, 435(1988),159-1667. T. Y. Zhang, et al, Separation of Alkaloids From Stephanis Tetrandra S.Moore by Analytical High Speed Countercurrent Chromatography. Journa

11、l of Liquid Chromatography, 11(8),(1998),1661-1671.8. T. Y. Zhang, X. N. Li and Y.Yuan, Preliminary Study for Separating Chlamydia Tracchomatis from Suspension of Yolk-Sac of Chick Embryos by Using a Non-Synchronous Coil Planet Centrifuge. Abstracts of the Pittsburgh Conference on Analytical Chemist

12、ry and Applied Spectroscopy. No. 971(1988)9. , et al, Separation of Hydroxyanthraquinane Derivatives Extracted from Rheum with Analytical High Speed Countercurrent Chromatography. Journal of Chromatography, 442(1988), 455-458.10. T. Y. Zhang, et al, Rapid Separation of Flavonoids by Analytical High-

13、Speed Countercurrent Chromatography. Journal of Chromatography, 445 (1988), 199-206.11. T. Y. Zhang, et al, Preliminary Applications of Cross-Axis Synchronous Flow-Through Coil Planet Centrifuge for Large-Scale Preparative countercurrent Chromatography. Journal of Chromatography, 454(1988), 185-193.

14、12. D. G . Cai, T. Y. Zhang, et al, Semi-preparative Separation of Alkaloids from Cephalotaxus Fortunei Hook F. by High Speed CCC, J. of Liquid Chromatogr., 15 (15&16) (1992) 2873-2881.13. T. Y. Zhang, et al, Purification of (-)-epigallocatechin from Enzymatic Hydrolysate of its Gallate Using High S

15、peed CCC, Journal of Chromatography A, 687(1994), 174-177.14. T. Y. Zhang, et al, Purification of 25-Hydroxy-Cholecalciferol from lrradiation of Cholesta 5, 7 diol by HSCCC, J. of Liquid Chromatogr.,18(1), (1995).181-188.15. T. Y. Zhang, Chapter 8, HSCCC on Medicinal Herbs, High-Speed CCC, Vol. 132

16、in Chem. Anal: A Series of Monographs on Anal. Chem. and its Appli., New York, John Wiley & Sons(1996) (Monograph).16. F. Q. Yang, T . Y. Zhang, et al, Preparative Separation and Purification of Kaempferol, Isorhamnetin, and Quercetin by HSCCC, Journal of Liquid Chromatography & Related Technologies

17、, 21(1 & 2)(1998), 209-216.17. X. L. Cao, T. Y. Zhang, et al, Semi-Preparative Separation and Purification of Taxol Analogs by HSCCC, Preparative Biochemical & Biotechnology, 28(1) (1998), 79-87.18. X. L. Cao, T. Y. Zhang, et al, separation and Purification of 10-deacetylbaccatin III by HSCCC, Journ

18、al of Chromatography A, 813(1998), 397-401.19. X. L. Cao, T. Y. Zhang, et al, HSCCC Separation of a Stilbene Glucoside from Polygonum multiflorum, Journal of Liquid Chromatography & Related Technologies, 21(18) (1998).20. , T. Y. Zhang, et al, Application of Analytical and Preparative HSCCC in The S

19、eparation of Alkaloids from Coptis chinensis Franch, Journal of chromatography A, 829(1998), 137-141.21. T. Y. Zhang, Separation and Purification of Active Compounds from Natural Products and Medicinal Herbs, South Asia-China Technological & Economic cooperation Exchange (SACTESX98), New Delhi, Lndi

20、a, 20-23 April(1998).22. X. L .Cao, Y. Tian, T. Y. Zhang, X. Li, Y. Ito, Separation and purification of isoflavones from Pueraria lobata by HSCCC, J. of Chromatogr. A, 885(1999)709-713.23. G. L. Tian , T.Y. Zhang, F. Q. Yang, Y. Ito, Separation of gallic acid from Cornus officinalis Sieb. Et Zucc by

21、 HSCCC. J. Chromatogr. A, 886(2000), 309-312.24. T. Y. Zhang, Separation of Compounds in Medicinal Herbs, Including Alkaloids: High-Speed Countercurrent Chromatography, Encyclopedia of Separation Science, London, Academic Press Ltd.(2000). (Monograph).25. G. L. Tian, Y. B. Zhang, T. Y. Zhang, F. Q.

22、Yang,Y. Ito, Separation of Tanshinones from Salvia miltorrhiza Bunge by HSCCC using stepwise elution, J. Chromatogr. A, 904(2000), 107-111.26. Y. Wei, T. Y. Zhang, Y. Ito, Proteins separation and purification of Morchella esculenta (L.) glycoprotein using the cross-axis CCC with a polymer phase syst

23、em. J. Chromatogr. A, 917(2001), 169-173.27. Y. Wei, T. Y. Zhang, G. Q. Xu, Y. Ito, Application of analytical and preparative HSCCC, for separation of lycopene from crude extract of tomato paste. J. Chromatogr. A, 929, (2001),169-173.28. H. B. LI, F. Chen, T. Y. Zhang, F. Q. Yang, G. Q. Xu, Preparat

24、ive isolation and purification of lutein from the microalga Chlorella vulgaris by HSCCC, J. Chromatogr. A, 905(2001), 151-155.29. L. Lei, F. Q. Yang, T. Y. Zhang, P. F. Tu, L. J. Wu, Y. Ito, Preparative isolation and purification of acteoside and 2-acetyl acteoside from Cistanches salsa (C. A. Mey)

25、G. Beck by HSCCC, J. Chromatogr. A , 912,(2001),181-185.30. G. L. Tian, Y. B. Zhang, T. Y. Zhang, Y. Ito, Separation of Tanshinones from Salvia miltiorrhiza Bunge by multidimensional counter-current chromatography. J. Chromatogr. A, 945(2002),237-241.31. X. Han, T. Y.Zhang, Y. Wei, X. L. Cao, Y. Ito

26、, Separation of Salidroside from Rhodiola Crenulata by HSCCC, J. Chromatogr. A, 971(2002), 237-241.32. X. F. Ma, T. Y. Zhang, Y. Wei, P. F. Tu, Y. J. Chen, Y. Ito, Preparative isolation and purification of calycosin from Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao by HSCCC, J. Chromat

27、ogr. A, 962, (2002),243-247. 33. T. Y. Zhang, Separation and purification of natuial products (Medicinal herbs) by HSCCC, Comprehensive Analytical Chemistry, Vol.XXXVIII. Countercurrent chromatography-the support free liquid stationary phase. ELSEVIER, (2002),(Monograph).34. T. Y. Zhang, Separation

28、of National Certified Reference Materials of active compounds from natural products by Countercurrent Chromatography, A special issue of Journal of Liquid Chromatogr. & Related Tech.,26(9&10) (2003), 1565-1578.35. , , , ,Y.Wei, Y.Ito, Preparative isolation and purification of two isoflavons from Ast

29、ragalus membranaceus Bge. Var. mongholicus (Bge.) Hsiao by HSCCC, J.Chromatogr. A, 992(2003)193-197.36. Y.Wei, ,Y.Ito, Preparative separation of rhein from Chinese Traditional herb by repeated HSCCC, J. Chromatogr. A, 1017(2003),125-130.37. X.Han, , Y.Ito, Separation of high purity przewaquinone A b

30、y HSCCC, J.Liqulid Chromatogr. & Related Tech., 26(8)(2003),1267-1274.38. , , , ,Y.Wei, Y.Ito, Preparative isolation and purification of isoflavan and pterocarpan glycosides from Astragalus membranaceus Bge. Var. mongholicus (Bge.) Hsiao by HSCCC, J.Chromatogr. A, 1023(2004),311-315.39. Y.Wei, ,Y.It

31、o, Preparative isolation of osthol and xanthotoxol from Common Cnidium Fruit (Chinese traditional herb ) using stepwise elution by HSCCC, J.Chromatogr. A, 1033(2004), 373-377.40. Y.Liang, , Y.Ito, Preparative isolation and purification of two closely related glycoside flavonoids from Exocarpium citr

32、i Grandis by HSCCC, J.Liqulid Chromatogr. & Related Tech., 30(2007),419-430.41. X.Wang, , Y.Ito, Application of preparative HSCCC for separation of elatin from Delphiniuum shawurense, J.Liqulid Chromatogr. & Related Tech., 30(2007),2585-2592.42. , The applications of HSCCC on Modernization of Traditional Chinese Medicine, The 5th International Conference of Countercurrent Chromatography, Rio de Janeiro, Basil, July 27-31, 2008.43. X.Wang, , et. al., Preparative s