1、常见肿瘤化疗方案常见肿瘤化疗方案(2004.10.30)一、头颈部癌1、DDP+5-FuCisplatin100mg/m2i.v.(1h inf)d15-Fluorouracil1000mg/m2i.v.(cont inf)d1-4(5)34周重复,也可用于放疗前2、CBP+5-FuCarboplatin300mg/m2i.v.d15-Fluorouracil1000mg/m2i.v.(cont inf)d1-434周重复3、IPIfosfamide(异环磷酰胺)1500mg/m2i.v.(Mesna 保护)d1-5Cisplatin10mg/m2i.v.(30min inf)d1-54周重复
2、4、TIPPaclitaxel(紫杉醇)175mg/m2i.v.(3h inf)d1Ifosfamide1000mg/m2i.v.(2h,Mesna 保护)d1-3Cisplatin60mg/m2i.v.d134周重复5、TICPaclitaxel175mg/m2i.v.(3h inf)d1Ifosfamide1000mg/m2i.v.(2h,Mesna 保护)d1-3CarboplatinAUC=6i.v.(30min inf)d134周重复6、Docetaxel+CisplatinDocetaxel(多西紫杉醇)100mg/m2i.v.(1h inf)d1Cisplatin75mg/m2i
3、.v.(3h inf)d13周重复7、Docetaxel+Cisplatin+5-Fluororacil(TPF)Docetaxel75mg/m2i.v.d1Cisplatin100mg/m2i.v.d15-Fluorouracil1000mg/m2i.v.(cont inf)d1-43周重复8、PBFCisplatin100mg/m2i.v.(1h inf)d1Bleomycin(博来霉素)15mgi.v.(bolus)d1 followed by16mg/m2i.v.(cont inf)d1-55-Fluorouracil650mg/m2i.v.(cont inf)d1-54周重复9、BE
4、CCisplatin100mg/m2i.v.(1h inf)d1Epirubicin(表柔比星)70mg/m2i.v.(bolus)d1Bleomycin15mgi.v.(bolus)d1 followed by12mg/m2i.v.(cont inf)d1-54周重复二、乳腺癌1、经典CMFCyclophosphamide(环磷酰胺)100mg/m2p.o.d1-14Methotrexate(氨甲喋呤)40mg/m2i.v.d1,85-Fluorouracil600mg/m2i.v.d1,84周重复2、改良CMFCyclophosphamide600mg/m2i.v.d1Methotrexa
5、te40mg/m2i.v.d15-Fluorouracil600mg/m2i.v.d13周重复3、ACDoxorubicin(阿霉素(化疗药物)60mg/m2i.v.d1Cyclophosphamide600mg/m2i.v.d1(,8)3周重复4、ECEpirubicin60mg/m2i.v.d1Cyclophosphamide600mg/m2i.v.d13周重复5、IEIfosfamide2000mg/m2i.v.(Mesna 保护)d1,8Epirubicin30mg/m2i.v.d1,83周重复6、AC+TDoxorubicin60mg/m2i.v.d1Cyclophosphamide
6、600mg/m2i.v.d13周重复,共4周期,然后Paclitaxel175mg/m2i.v.(3h inf)d13周重复,共4周期7、CAFCyclophosphamide500mg/m2i.v.d1Doxorubicin50mg/m2i.v.d15-Fluorouracil500mg/m2i.v.d13周重复8、CEFCyclophosphamide500mg/m2i.v.d1Epirubicin100mg/m2i.v.d15-Fluorouracil500mg/m2i.v.d13周重复9、Paclitaxel单药Paclitaxel175或200mg/m2i.v.(3h inf)d13
7、周重复10、TADoxorubicin50mg/m2i.v.d1Paclitaxel220mg/m2i.v.(3h inf)d2(ADM后24h)3周重复11、Docetaxel单药Docetaxel75或100mg/m2i.v.(1h inf)d13周重复或者Docetaxel40mg/m2i.v.(1h inf)qw*4/6w3周重复12、Docetaxel+DoxorubicinDoxorubicin50mg/m2i.v.d1Docetaxel75mg/m2i.v.(1h inf)d13周重复13、Vinorelbine+DoxorubicinDoxorubicin40-50mg/m2i
8、.v.d1Vinorelbine20-25mg/m2i.v.d1,83周重复14、Capecitabine单药Capecitabine2510mg/m2p.o.分两次天,d1-143周重复15、Trastuzumab单药Trastuzumab4mg/kgi.v.(90 min inf)负荷量2mg/kgi.v.(30 min inf)维持量,qw三、肺癌(一)小细胞肺癌的化疗(SCLC)1、CAOCyclophosphamide1000mg/m2i.v.d1Doxorubicin(阿奇霉素)50mg/m2i.v.d1Vincristine2mgi.v.d13周重复2、CEVCyclophosp
9、hamide1000mg/m2i.v.d1Epirubicin70mg/m2i.v.d1Vincristine2mgi.v.d13周重复3、EPCisplatin80mg/m2i.v.(1h inf)d1Etoposide100mg/m2i.v.(2h inf)d1-33周重复4、ECCarboplatin300mg/m2i.v.d1Etoposide120mg/m2i.v.(2h inf)d1-34周重复5、CAECyclophosphamide1000mg/m2i.v.d1Doxorubicin40-50mg/m2i.v.d1Etoposide100-120mg/m2i.v.(1h inf
10、)d1-33周重复6、VIPEtoposide75mg/m2i.v.d1-4Ifosfamide1200mg/m2i.v.(Mesna 保护)d1-4Cisplatin20mg/m2i.v.d1-43周重复7、Topotecan单药Topotecan1.5mg/m2i.v.(30min inf)d1-53周重复8、Paclitaxel+CarboplatinPaclitaxel175mg/m2i.v.(3h inf)d1CarboplatinAUC=7i.v.(30min inf)d13周重复(二)非小细胞肺癌的化疗(NSCLC)1、Docetaxel单药Docetaxel75mg/m2i.v
11、.(1h inf)d13周重复2、Gemcitabine单药Gemcitabine1000-1250mg/m2i.v.(30min inf)d1,8,154周重复3、Vinorelbine单药Vinorelbine30mg/m2i.v.(20min inf)d1,8,154周重复4、NPVinorelbine25mg/m2i.v.d1,8,15Cisplatin100mg/m2i.v.d14周重复5、Paclitaxel+CisplatinPaclitaxel175mg/m2i.v.(3h inf)d1Cisplatin80mg/m2i.v.(1h inf)d13周重复6、Paclitaxel
12、+CarboplatinPaclitaxel225mg/m2i.v.(3h inf)d1CarboplatinAUC=6i.v.d13周重复7、Docetaxel+CisplatinDocetaxel75mg/m2i.v.d1Cisplatin75mg/m2i.v.d13周重复8、Gemcitabine+CisplatinGemcitabine1000mg/m2i.v.(30-60min inf)d1,8,15Cisplatin100mg/m2i.v.(30-60min inf)d14周重复9、EPCisplatin100mg/m2i.v.(30-60min inf)d1Etoposide10
13、0mg/m2i.v.(2h inf)d1-33周重复四、食管癌1、DDP+5-FuCisplatin100mg/m2i.v.(2h inf)d15-Fluorouracil1000mg/m2i.v.(cont inf)d1-534周重复2、Paclitaxel+CisptatinPaclitaxel180mg/m2i.v.(3h inf)d1Cisplatin60mg/m2i.v.(3h inf)d13周重复3、TPEPaclitaxel50mg/m2i.v.(1h inf)d1,4Cisplatin15mg/m2i.v.(1h inf)d1,4Etoposide50mg/m2i.v.(con
14、t inf)d1,4QW*3,休息1周,4周一疗程4、ECFEpirubicin50mg/m2i.v.d1Cisplatin60mg/m2i.v.d15-Fluorouracil200mg/m2i.v.(cont inf)d1-213周重复五、胃癌1、5-Fu+CF+DDPCisplatin50mg/m2i.v.(1h inf)biwFolinic acid500mg/m2i.v.(2h inf)qw*65-Fluorouracil2000mg/m2i.v.(24h inf)qw*62、ECFEpirubicin50mg/m2i.v.d1Cisplatin60mg/m2i.v.d15-Fluo
15、rouracil200mg/m2i.v.(cont inf)d1-213周重复3、FAMTXMethotrexate11.5g/m2i.v.d15-Fluorouracil1500mg/m2i.v.d1Doxorubicin30mg/m2i.v.d15Folinic acid15mg/m2p.o.MTX后24h,q6h*124周重复4、ELFEtoposide120mg/m2i.v.(50min inf)d1-3Folinic acid300mg/m2i.v.(10min inf)d1-35-Fluorouracil500mg/m2i.v.(10min inf)d1-334周重复5、TCDoc
16、etaxel85mg/m2i.v.(1h inf)d1Cisplatin75mg/m2i.v.(1h inf)d13周重复六、大肠癌1、Mayo ClinicFolinic acid20mg/m2i.v.(bolus)d1-55-Fluorouracil425mg/m2i.v.(bolus)d1-54周重复2、de GramontFolinic acid200mg/m2i.v.(2h inf)d1-25-Fluorouracil400mg/m2i.v.(bolus)d1-2600mg/m2i.v.(22h inf)d1-22周重复3、Irinotecan MonotherapyIrinotec
17、an125mg/m2i.v.(90min inf)qw*46周重复或者Irinotecan300-350mg/m2i.v.(90min inf)d13周重复4、FOLFORIIrinotecan125mg/m2i.v.(90min inf)qw*4Folinic acid20mg/m2i.v.(bolus)qw*45-Fluorouracil500mg/m2i.v.(bolus)qw*46周重复或者Irinotecan180mg/m2i.v.(90min inf)d1Folinic acid200mg/m2i.v.(2h inf)d1-25-Fluorouracil400mg/m2i.v.(b
18、olus)d1-2600mg/m2i.v.(22h inf)d1-22周重复5、Irinotecan+OxaliplatinIrinotecan200mg/m2i.v.(30min inf)d1Oxaliplatin85mg/m2i.v.(2h inf)d13周重复6、Oxaliplatin MonotherapyOxaliplatin130mg/m2i.v.(2h inf)d13周重复7、FOLFOX4Oxaliplatin85mg/m2i.v.(2h inf)d1Folinic acid200mg/m2i.v.(2h inf)d1-25-Fluorouracil400mg/m2i.v.(b
19、olus)d1-2600mg/m2i.v.(22h inf)d1-22周重复8、FOLFOX6Oxaliplatin100mg/m2i.v.(2h inf)d1Folinic acid400mg/m2i.v.(2h inf)d15-Fluorouracil400mg/m2i.v.(bolus)d1-224003000mg/m2i.v.(46h inf)d1-22周重复9、RaltitrexedRaltitrexed3mg/m2i.v.d13周重复10、CapecitabineCapecitabine1250mg/m2p.o.bid*143周重复11、UFT+CFUFT100mg/m2p.o.t
20、id*28Folinic acid30mg/m2p.o.tid*285周重复七、胰腺癌1、GemcitabineGemcitabine1000mg/m2i.v.(30min inf)qw*7;休息1周后每周1次,连用3周,4周一疗程2、5-Fluorouracil5-Fluorouracil500mg/m2i.v.(bolus)d1-54周重复3、CF+5-FuFolinic acid20mg/m2i.v.(2h inf)d1-55-Fluorouracil425mg/m2i.v.(bolus)d1-54周重复4、Gemcitabine+CF+5-FuGemcitabine1000mg/m2i
21、.v.(30min inf)d1,8,15,22Folinic acid200mg/m2i.v.(2h inf)d1,8,15,225-Fluorouracil750mg/m2i.v.(cont inf)d1,8,15,226周重复八、胆管癌1、5-Fluorouracil5-Fluorouracil500mg/m2i.v.d1-54周重复或者5-Fluorouracil600mg/m2i.v.d1,8,154周重复2、GemcitabineGemcitabine1000mg/m2i.v.(30min inf)d1,8,154周重复3、GemcitabineGemcitabine2200mg/
22、m2i.v.(30min inf)d12周重复4、DocetaxelDocetaxel100mg/m2i.v.(1h inf)d13周重复5、FLMFolinic acid200mg/m2i.v.d1-45-Fluorouracil400mg/m2i.v.d1-4Mitomycin8mg/m2i.v.d14周重复6、5-Fu+IFN-a5-Fluorouracil750mg/m2i.v.(cont inf)d1-5Interferon alpha5*106IUs.c.d1,3,52周重复九、宫颈癌1、IPIfosfamide5000mg/m2i.v.(24h inf,Mesna保护)d1Cis
23、platin50mg/m2i.v.d13周重复2、ICIfosfamide5000mg/m2i.v.(24h inf,Mesna保护)d1Carboplatin300mg/m2i.v.d14周重复3、BIPBleomycin30mg/m2i.v.(24h inf)d1Ifosfamide5000mg/m2i.v.(24h inf,Mesna保护)d2Cisplatin50mg/m2i.v.d24周重复4、TIPPaclitaxel175mg/m2i.v.(3h inf)d1Ifosfamide5000mg/m2i.v.(24h inf,Mesna保护)d2Cisplatin50mg/m2i.v
24、.d24周重复5、TPPaclitaxel135mg/m2i.v.(24h inf)d1Cisplatin5075mg/m2i.v.d23周重复6、PFCisplatin75mg/m2i.v.d15-Fluorouracil1000mg/m2i.v.(cont inf)d1-43周重复,也可同时合并放疗十、子宫膜癌1、APDoxorubicin60mg/m2i.v.d1Cisplatin5060mg/m2i.v.d13周重复2、TCPaclitaxel175mg/m2i.v.(3h inf)d1CarboplatinAUC=57i.v.(30min inf)d13周重复3、PCDDoxorub
25、icin45mg/m2i.v.d1Paclitaxel160mg/m2i.v.(3h inf)d1Cisplatin60mg/m2i.v.(1h inf)d13周重复,G-CSF支持十一、卵巢癌一线化疗1、TPPaclitaxel135mg/m2i.v.(3h或24h inf)d1Cisplatin75mg/m2i.v.(1mg/min)d1或d23周重复2、TCPaclitaxel175mg/m2i.v.(3h inf)d1CarboplatinAUC=56i.v.(1h inf)d13周重复3、CBP+CTXCyclophosphamide600mg/m2i.v.d1Carboplatin300mg/m2i.v.(1h inf)d14周重复挽救治疗1、TopotecanTopotecan1.01.5mg/m2i.v.(30min inf)d1-53周重复2、EtoposideEt
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