1、证明咬合干扰可加重慢性心理应激致大鼠焦虑样行为。利用人类全基因表达谱芯片发现MEK3-p38 MAPK信号通路参与慢性咀嚼肌疼痛。利用功能性磁共振成像发现咬合相关口颌面疼痛伴有丘脑与前扣带回功能改变。(2)研究咬合疾病对颅颌系统的影响特点:利用标准化定量感觉测试首次研究咬合相关慢性口面痛中国患者的躯体感觉功能改变。揭示有单侧咬合高点患者的咀嚼肌肌电活动特征及与口面痛的关系。发现咬合丧失可导致自然头位发生改变,以及海马内神经物质代谢改变,恢复咬合支持有利于头位的平衡及改善海马神经元功能;重度磨耗致咬合垂直距离降低可影响咀嚼肌耐受疲劳的能力。(3)研究预防和治疗的方法:阐明咬合干扰强度和持续时间以
2、及疼痛记忆对慢性口面痛的影响特点,为临床预防提供指导。揭示外源性ATP介导牙本质再生的作用机制,为重度磨耗致牙齿敏感性疼痛提供新的治疗策略。证实抑制中枢NMDA受体及阻断MAPK信号通路可缓解咬合干扰致慢性口面痛,为临床治疗提供新思路。发明牙齿触觉功能数字测试系统,揭示影响天然牙与种植体触觉阈值的因素及规律,为临床分析咬合疾病和个性化调(牙合)提供依据。本项目完成4项国家级和1项省部级课题,研究成果发表论文52篇,他引338次。其中SCI收录14篇(包括Pain,Journal of Dental Research等疼痛和牙医学领域最高水平学术期刊),他引140次,总影响因子42.46(10篇
3、代表作他引118次,总影响因子30.698)。培养博士研究生18人,硕士研究生5人。主编专著3部。获得国家发明专利1项。多次在国内外学术会议做专题报告。连续6年举办国家级咬合理论与技术临床培训班,推广研究成果。 五、代表性论文、著作发表情况及第三方评价5.1代表性论文、著作发表情况(限10篇)检索机构序号论文(著作)名称刊名/出版社影响因子发表时间(年月日)通讯作者第一作者论文全部作者SCI他引次数EI他引次数他引总次数年卷期页码是否国内完成1Experimental occlusal interference induces long-term masticatory muscle hype
4、ralgesia in ratsPain5.3712009-05-26谢秋菲,傅开元曹烨曹烨,谢秋菲,李楷,Light A R,傅开元17392009,144(3) : 287-293是2Molecular Changes Involving MEK3-p38 MAPK Activation in Chronic Masticatory MyalgiaJournal of Dental Research4.7552016-07-14谢秋菲孟贺孟贺,高原,康艳凤,赵燕平,杨广聚,王洋,曹烨,甘业华,谢秋菲2016,95(10) : 1169-11753Central sensitization
5、and MAPKs are involved in occlusal interference-induced facial pain in ratsJournal of Pain4.2162013-05-01曹烨,李楷,傅开元,谢秋菲,Chiang C Y, Sessle B J12182013,14(8) : 793-8074Somatosensory abnormalities in Chinese patients with painful temporomandibular disordersJournal of Headache and Pain3.582016-04-12杨广聚杨
6、广聚,Baad Hansen L,王克伦,傅开元,谢秋菲,Svensson P2016,17: 315Role of TRPV1 and ASIC3 channels in experimental occlusal interference-induced hyperalgesia in rat masseter muscleEuropean Journal of Pain3.0192016-03-11曹烨,谢秋菲徐啸翔徐啸翔,曹烨,丁婷婷,傅开元,李婴,谢秋菲62016,20(4) : 552-563Inflammatory pain memory facilitates occlusal
7、 interference-induced masticatory muscle hyperalgesia in rats2016-02-15谢秋菲,甘业华丁婷婷丁婷婷,徐啸翔,曹烨,刘存瑞,甘业华,谢秋菲2016,20(3) : 353-3647Effects of Adenosine Triphosphate on Proliferation and Odontoblastic Differentiation of Human Dental Pulp CellsJournal of Endodontics2.8072016-08-26王薇,易小松王薇,易小松,任延方,谢秋菲2016,42(
8、10) : 1483-14898Ethnic differences in oro-facial somatosensory profiles-quantitative sensory testing in Chinese and DanesJournal of Oral Rehabilitation1.9342013-08-26杨广聚,Luo Y,Baad Hansen L,王克伦,Arendt Nielsen L,谢秋菲,Svensson P92013,40(11) : 844-853The electromyographic activity of masseter and anteri
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10、otor Research0.6412014-01-07杨广聚,Baad Hansen L,王克伦,谢秋菲,Svensson P2014,31(2) : 62-715.2代表性论文、著作被他人引用情况(限10篇)被引代表性论文、著作序号引文名称/引文作者刊名/影响因子(引文)引文发表时间(年 月 日)KChIP3 N-Terminal 31-50 Fragment Mediates Its Association with TRPV1 and Alleviates Inflammatory Hyperalgesia in Rats. /Tian, N.X., Xu, Y., Yang, J.Y
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12、ison, D.S. and Dougherty, P.M. Brain Behavior and Immunity/5.8742015-06-09Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations. /Edwards, R.R., Dworkin, R.H., Turk, D.C., Angst, M.S., Dionne, R., Freeman, R., Hansson, P., Haroutounian, S., Arendt-Nielsen, L., At
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