科技论文邮件英文常有表达.docx

科技论文邮件英文常有表达.docx

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科技论文邮件英文常有表达

1．Tofurthersubstantiatearoleof…..

2．Togainfurtherinsightintotheinvolvementof……

3．Severallinesofevidencesuggestapotentialroleof……

4．Thediscrepanciesbetweenthesestudiesmaybeexplainedinpartbythefactthat….

5．Itcanalsonotbeexcludedthat…..

6．Tofurtherelucidatetheroleof…….

7．Thereisgrowingevidencethat……….

8．Severalstudiesindicatethat…………

9．Itisgenerallyacceptedthat………..

10.Invitrostudiesrevealedthat………….

11.Thisissomewhatsurprisingsince………

12.Furthermore,availabledatasuggestthepotentialto……..

13.developmentandgenerationofmorespecificinhibitorswillberequiredtofurtherexploretheirpotentialto………..

14.Abetterunderstandingoftheregulationoftheirexpressionwillthusbe…….instrumentalinthedevelopmentofspecifictargetingapproaches…….

15.Littleisknowneitheron……….

16.………….remaintobeelucidatedinmoredetail

17.Theaimofthisstudywastoclarifywhether…..weretherapeuticagentsagainst

18.Thisstudymayprovideanewrecognitionofnaturalmedicineforthetreatmentof

19.Epidemiologicalstudieshaveshowntheincidenceof

20….arethoughttoactthroughreceptor-independentanddependentmechanismstopromote…

21.…..whicharederivedfrom…..,havebeenreportedtopossessavarietyofpotentproperties,includingantioxidant,anti-inflammation,radical-scavenging,andcardiovascularprotectingactivity,anti-tumor,andsoon.

22.Thepurposeofthisstudywastoexaminetheeffectsof….andtoevaluatetheefficacyofcardioprotectionby…….

23.Thepathologicalfeaturesofdiabetesand/oritscomplicationsthatwerecausedby….hadbeeninvestigatedextensively.

15.IthasbeenestablishedthatTGF-b1wasamajorregulatorofcollagenbiosynthesis.

16.Asdiscussedabove,itwasdiscoveredthat…..showedbeneficialinfluenceson…..andhadcardioprotectiveeffects,suggestingthat…..mayameliorate…….

17.However,themechanismsresponsiblefortheeffectsof….on…stillneedtobediscussed.

18.Thisstudyelucidatedthefunctionalroleof….against……mayprovidenovelevidenceforanantidiabeticproperty.

19.…sparkedintensedebateandresearchintothecardiovascularsecurityof…

20.Anupdatedreviewof

21.Thesignificanceofthisfindingrestsonthefactthat….

22.….whatisinagreementwithliteraturedata

23.Thevalueandnoveltyofthisstudyistoindicate,forthefirsttimeinaninvivomodel,thatthemolecularmechanismofatherosclerosispreventionby……isconsistentwithadiminutionoftheclassBscavengerreceptorCD36expression

24.Thequestionremainsopenastowhy….

25…..mayleadtoabetterunderstandingofthediscrepanciesamonghumanstudiesandwiththeanimalones.

26.….numerousstudiessuggestthatithasapreventiveroleinatherosclerosis,althoughthemechanismofactionstillremainsunclear.

27.Theoriginalaimofthisstudywastoestablishwhether…..

28.Expressionofsomeofthescavengerreceptorsisincreasedattheatheroscleroticlesion,8buttodate

theregulatorymechanismsformostofthesegenesarenotyetknownandcouldleadtoabetterunderstandingoftheprocess,prevention,andtherapyofthisdisease.

29.Thisfindingisimportantinthelightofthestillunknownmechanismoffoam-cellformationfromhumanaorticSMCs.

30.TheresultsshowninFigureexcludedthishypothesis,

31.Treatmentofcellswitha-tocopherol（50mmol/L）resultedinatime-dependentdecreaseofCD36proteinexpression（Figure2B）,aswasobservedatthemRNAlevel.

32.Anunderstandingofthemechanismsbywhich……iscentraltoanunderstandingof……

33.……remainstobedetermined…..recentdatasupportanimportantrolefor….inthepathogenesisofAs.

34.However,mountingevidencesuggeststhat……

35.….althoughthebiologicalfunctionhasnotbeendefined…..

36.Giventheestablishedroleof……,weexploredwhether.

37.Inthefollowingwork,weoutlinedanovelsignalingpathwayfor…..thesefindingssuggestanunexpectedrolefor…..inthepathogenesisofAs

38.Theexpressionof…..in,ledustosearchforitsexpressionin…..Toaddressthisissue,weperformedIFmicroscopyusingantibodiesagainst….

39.Todeterminewhether…..wasalsoexpressedin….,weperformedICH.Asshowninfigure,thenucleiof….showstrongstainingfor……Bycontrast,nostainingisseenin…..

40.Asanticipated,cellstreatedwith…exhibitedareductionin…..Unexpectedly,….NOeffectwasobservedwithor….thisobservationsuggestthat…..

41.Tofurthercharacterizetheeffectof…on….,weexamined…..

42.Todeterminewhether…..Theeffectof….werealsoexaminedin…..wealsoexaminedtheabilityof…on….Thisfindingsindicatethat….

42.Accordingly,weconsiderthepossibilitythat….

43.Surprisingly,…..Thisresultsestablishedalinkbetween…..and…..

44.SinceOx-LDLstimulatedPPARexpression,wespeculatedthat……

45.Asdemonstratedin….,similarresultswereobtainedwhen……

46.Wefurtherexaminedtheeffectof….thesurfaceexpressionofCD36by….

47….hasbeenreportedpreviouslytobeaneffectiveinducerof…..induceexpressionof….in…cells.

48.inducesignificantexpressionofmRNAencoding……similarresultswereobtainedwhen…wasusedas…..

49.toinvestigatewhether…..and…arelinked,weutilizeda…..thathasbeendemonstratedpreviouslytointerferewith….

50.whileitispossiblethat…..makeminorcontributionsto,thisdataindicatethattheeffectIismediatedprimarilybySRCD36.

51.Theobservationthat….raisedthepossibilitythat….

52.Toinvestigatewhether….functiontoregulatetranscriptionof….promoter,

53.toconfirmthat….collectively,theseresultssuggeststhat….

54.TheabovefindingsraisedtheIntriguingpossibility……..

55.AdetailedunderstandingofthemolecularandcellulareventsthatunderlieformationofAsplaque,isprerequisitetotherationaldesignofthetherapeuticofthedisease.

56.Inthiswork,wehavepresentedevidenceimplicating…..inanovelsignalingpathwaythatregulatedifferentiationandlipidmetabolismin…..

57.….endowscultured….cellswiththeabilitytobindandinternalizedOxLDL.

58.ourobservationthat…..suggestthat…..maybeimportantforthemodulationofgeneexpressioninthiscontext.

59.Infact,wehaverecentlydemonstratedthat….Thisobservationrevealsanovelmechanismwhereby……

60.itfitswellwiththepreviouslydefinedroleof….

61.Althoughpriorworkhasfocusedprimarilyon,itislikelythat…..

62.thereisstrongevidencethat….alloftheseobservationsareconsistentwithouridentification….as….

63.ourfindingsthat……,that…..,andthat…..,collectivelysuggestthat…..mayplayarolein…..Clearly,invivostudieswillberequiredtofurtheraddressthepossibility.

64.Inthecaseof…,anumberofstudieshaveprovidedcompellingevidencethat….

65.theworkpresentedhereinhasinmanycasesutilized…..inaneffort/attemptto….

66.Itistemptingtospeculatethattheelucidationofanuclearreceptorsignalingpathwayinvolvedin…..mayopenthedoorfortherapeuticinterventionofthisprocess,

67.sincetherelationshipbetween….Andatherogenesisiscomplex,theinfluenceof…on…mustalsobetakenintoaccount.

68.Clearly,invivostudieswillberequiredtodeterminewhether…havepotentialutilityinthetreatmentorpreventionofatherogenesis.

69．Toexploretheideathat……wasusedtoidentify……

70．Furthermore,thesestudiesdemonstrate…..tobeanimportantsignalingmoleculein…..andmayserveasatherapeutictargetinthepreventionandtreatmentofvasculoproliferativedisorders

72.havebeenwidelyusedinclinicalpractiseandtheirefficacyinreducingcardiovascularriskhasbeenwelldescribed

73.Theseresultssuggestthat…..hasapotentprotectiveeffectagainst….Thefindingsprovideanewinsightintothemechanismbywhich

74.Despiteextensivestudies,thefundamentalmechanismsresponsibleforthedevelopmentandprogressionofcardiovasculardiseaseshavenotyetbeenfullyelucidated.Recentexperimentalandclinicalstudieshavesuggestedthatreactiveoxygenspeciesplayamajorpathologicalrole

75.However,itremainsunknownwhether…….

76.….hasbeenshowntopossessvariouspharmacologicalactivitiessuchasanti-oxidativeandanti-inflammatoryactivities.

77.…recognizedasamoleculartargetforanti-inflammatory

78.…Furthermore,wehaveconfirmedaninvolvementofreactiveoxygenspecies（ROS）in..

79...Thepresentstudywasattemptedtoinvestigatetheeffect…..

80.Allotherreagentswereofthebestgradecommerciallyavailable…..

81.TheexperimentsinthisarticlewereconductedinaccordancewithguidelinesestablishedbytheAnimalCareandUseCommitteeof…..University.

82.…cellsweregenerouslyprovidedby…maintainedin….

83.Toelucidatethemechanismsof…..action,itseffecton….wasexaminedby…..

84.…..mayhavepromisingbeneficialeffectsinpreventing…..andmaybeofsignificancefromtheaspectof…..

85.Instudiesofthemolecularmechanismsof…..Apreviousreportindicatedthat

86.Tostudytheroleof…..wedesignedanantisensetodepletetheendogenous….protein.

87.Consistentwiththefactthat….dominant-negative…didnotrescuetheeffectof…..

88.Theresultspresentedabovesuggestarequirementfor…in….Wefurtherexplored

thispossibilityusing,,,,,,

89.Asourresultssuggestedthat…..weattemptedtorescue….

90.Tofurthertesttherelationshipof…withthe…

91.Theactivationof….inresponseto…..signallingisrequiredfor…..,andtheresultspresentedabovesuggestthat…..isacomponentofthissignalingcascade

92.Totestthishypothesis,weperformed…..Thisfeaturemightexplainthefactthat

93.Invivoexperimentssuggestthat….Thisissupportedbythefact