pnca突变数据库文档格式.docx

pnca突变数据库文档格式.docx

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1996-1998

ZRHSE

Proportionmethod,BACTEC460

35/65

del11bp

2

ATG/ACG

Met/Thr

2000-2001

BACTECMGIT960

55

3

ATG/ATT

Met/Ile

2001

PZasetestwithWayne'

92/95

7

GCG/CCG

Ala/Pro

1986

ZHR

8

GCG/GAG

Ala/Glu

2006

Proportionmethod,rapidbrothmethod

17/138

11

TTG/TGG

4

Leu/Trp

TTG/TCG

Leu/Ser

14

ATC/AGC

5

Ile/Ser

19

GTC/ATC

Val/Ile

1995,1996

ZHRPES

11/29

GTC/TTC

Val/Phe

ZHRPS

20

GTC/GGC

Val/Gly

1997

ZHRSE

33/168

GTC/GAC

Val/Asp

22

GAC/TAC

Asp/Tyr

23

GAC/GGC

Asp/Gly

24

GAC/GAG

Asp/Glu

26

GTG/GCG

9

Val/Ala

GTG/GGG

GTG/TTG

Val/Leu

2001-2002

ZHRSEthK

115

68

27

GTG/TCG

Val/Ser

1994-2004

250

89

28

delC

10

CAA/AAA

Gln/Lys

CAA/TAA

Gln/STOP

29

CAG/CGA

Gln/Arg

1990-1992

ZHREO

59/59

CAG/CCG

Gln/Pro

CAG/CCA

34

GAC/AAC

12

Asp/Asn

35

GAC/GCC

Asp/Ala

38

TTC/TCC

13

Phe/Ser

1987

ZHRES

19/35

40

TGC/CGC

Cys/Arg

Cys/His

41

TGC/TAC

Cys/Tyr

47

delG

16

50

GGC/GAC

17

Gly/Asp

ZHRS

GGC/GTC

Gly/Val

52

insGG

56

CTG/CGG

Leu/Arg

CTG/CCG

Leu/Pro

62

GTA/GGA

21

64

delA

59

ZRSE

68-69

GGT/GTC

70

BACTEC460

7/0

71

ZRH

74-75

GCC/GAA

25

77

GCG/GGG

Ala/Gly

84

83

GCC/GAC

Ala/Asp

88-112

del24bp

1996-1999

BACTECradiometrictesting

3/11

98-216

del118bp

100

insT

101

TAC/TCC

Tyr/Ser

104

109-110

GGA/TAA

37

Glu/STOP

106

del5.3kb

Frame/TRUNC

121

TAC/CAC

Tyr/His

ZHRE

123

TAC/TAA

Tyr/STOP

Middlebrook7H11agarw/pHof6.0

TAC/TAG

128

CAC/CCC

43

His/Pro

134

45

136

Gins

46

ZHE

GCA/CCA

137

GCA/GAA

GCA/GTA

Ala/Val

139

ACC/CCC

Thr/Pro

ACC/TCC

Thr/Ser

ACC/GCC

Thr/Ala

11/0

145

GAC/CAC

49

Asp/His

146

GAC/GTC

Asp/Val

151

CAC/AAC

51

His/Asn

1998-2003

CAC/TAC

His/Tyr

23/62

151-230

del80bp

152

CAC/CGC

His/Arg

153

CAC/CAG

His/Gln

CAC/CAA

53

158

160

CCG/ACG

54

Pro/Thr

161

CCG/CTG

Pro/Leu

162

MDR

7H9liquidmedium,pH5.6;

PZaseactivityassayedaccordingtoWayne'

smethod

4/7

169

57

CAC/GAC

His/Asp

170

2000

ZHRP

BACTECradiometric-basedculturemethod,standardprotocol;

andPZaseactivity

13/18

CAC/CTC

His/Leu

172

delT

58

TTC/CTC

Phe/Leu

1995-1996

174

TTC/TTG

175

TCC/CCC

Ser/Pro

181

ACA/CCA

61

1992

185

CCG/CAG?

?

Pro/His

CCG/CGG

Pro/Arg

186

188

63

187

190

TAT/GAT

Tyr/Asp

192

insA

ZSHE

195-263

del68bp

196

TCG/CCG

66

199

67

202

TGG/CGG

Trp/Arg

TGG/GGG

Trp/Gly

203

TGG/TCA

Trp/STOP

TGG/TCG

Trp/Ser

TGG/TTG

Trp/Leu

206

CCA/CGA

69

CCA/CTA

1994

211

CAT/TAT

212

CAT/GAT

CAT/CGT

213

CAT/CAG

His/Glu

214

72

215

216

TGC/TGG

Cys/Trp

ins29bp

218

insCGCATTGCCG

221

insG

74

224

75

ZORH

BACTECMGIT960

89/250

226

ACT/CCT

76

227

ACT/ATT

Thr/Ile

8/0

233

78

236

79